Author | Reis, Alexandre Barbosa | |
Author | Giunchetti, Rodolfo Cordeiro | |
Author | Carrillo, Eugenia | |
Author | Martins Filho, Olindo Assis | |
Author | Moreno, Javier | |
Access date | 2013-09-30T14:07:11Z | |
Available date | 2013-09-30T14:07:11Z | |
Document date | 2010 | |
Citation | REIS, Alexandre Barbosa et al. Immunity to Leishmania and the rational search for vaccines against canine leishmaniasis. Trends Parasitol., v. 26, n. 7, p. 341-349, Jul. 2010. | pt_BR |
ISSN | 1471-4922 | |
URI | https://www.arca.fiocruz.br/handle/icict/7015 | |
Language | eng | pt_BR |
Publisher | Elsevier | |
Rights | restricted access | |
Title | Immunity to Leishmania and the rational search for vaccines against canine leishmaniasis | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.pt.2010.04.005 | |
Abstract | The control of infection by Leishmania infantum (syn. Leishmania chagasi) in dogs is essential to stop the current spread of zoonotic visceral leishmaniasis. The past few years have seen significant advances in achieving efficient immunization of dogs and, more than ever before, an effective vaccine against canine leishmaniasis can now be considered a feasible goal. This article summarizes experimental data gathered from recent dog trials aimed at identifying immunological mechanisms implicated in protection against canine infection to discuss their potential to serve as quantitative surrogate markers of immunization and, more importantly, its usefulness to evaluate whether the immunity induced by the vaccine candidate is strong enough to protect against canine leishmaniasis. | pt_BR |
Affilliation | Universidade Federal de Ouro Preto. Núcleo de Pesquisas em Ciências Biológicas. Laboratório de Imunopatologia. Ouro Preto, MG, Brazil / Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidade Federal de Ouro Preto. Núcleo de Pesquisas em Ciências Biológicas. Laboratório de Imunopatologia. Ouro Preto, MG, Brazil / Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Centro Nacional de Microbiologıa. Instituto de Salud Carlos III. Unidad de Inmunoparasitologıa. Majadahonda ,Madrid, Spain. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratório de Biomarcadores de Diagnostico e Monitoração. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Centro Nacional de Microbiologıa. Instituto de Salud Carlos III. Unidad de Inmunoparasitologıa. Majadahonda, Madrid, Spain. | pt_BR |
Subject | Leishmania/immunology | pt_BR |
Subject | Leishmaniasis Visceral/immunology | pt_BR |
Subject | Protozoan Vaccines/therapeutic use | pt_BR |