Please use this identifier to cite or link to this item:
https://www.arca.fiocruz.br/handle/icict/6774
PALLADIUM(II) COMPLEXES OF 2-BENZOYLPYRIDINE-DERIVED THIOSEMICARBAZONES: SPECTRAL CHARACTERIZATION, STRUCTURAL STUDIES AND CYTOTOXIC ACTIVITY.
Author
Affilliation
Universidade Federal de Minas Gerais. Departamento de Quımica. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Departamento de Quımica. Belo Horizonte, MG, Brazil.
Universidad de la Republica. Facultad de Quımica. Catedra de Quımica Inorganica. Montevideo, Uruguay.
Universidad de la Republica. Facultad de Quımica. Catedra de Quımica Inorganica. Montevideo, Uruguay.
Universidad Nacional de La Plata and Instituto. Facultad de Ciencias Exactas. Departamento de Fısica. La Plata, Argentina.
Universidade de Sao Paulo. Instituto de Fısica de Sao Carlos. Sao Carlos, SP, Brazil.
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil.
Universidade Federal de Sao Carlos. Departamento de Quımica. Sao Carlos, SP, Brazil.
Universidade Federal de Sao Carlos. Departamento de Quımica. Sao Carlos, SP, Brazil.
Universidade Federal de Minas Gerais. Departamento de Quımica. Belo Horizonte, MG, Brazil.
Universidad de la Republica. Facultad de Quımica. Catedra de Quımica Inorganica. Montevideo, Uruguay.
Universidad de la Republica. Facultad de Quımica. Catedra de Quımica Inorganica. Montevideo, Uruguay.
Universidad Nacional de La Plata and Instituto. Facultad de Ciencias Exactas. Departamento de Fısica. La Plata, Argentina.
Universidade de Sao Paulo. Instituto de Fısica de Sao Carlos. Sao Carlos, SP, Brazil.
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil.
Universidade Federal de Sao Carlos. Departamento de Quımica. Sao Carlos, SP, Brazil.
Universidade Federal de Sao Carlos. Departamento de Quımica. Sao Carlos, SP, Brazil.
Abstract
Palladium(II) complexes of 2-benzoylpyridine thiosemicarbazone (H2Bz4DH) and its N(4)-methyl (H2Bz4M) and N(4)-phenyl (H2Bz4Ph) derivatives were obtained and fully characterized. [Pd(2Bz4DH)Cl] (1) crystallizes in the monoclinic space groupP21 /c witha= 11.671(1),b= 10.405(1),c= 13.124(1),b= 115.60(1) and Z= 4; [Pd(2Bz4M)Cl] (2) in the monoclinic space group P21/cwitha= 9.695(1),b= 15.044(1),c= 10.718(1) A˚, b= 105.38(1)andZ= 4 and [Pd(2Bz4Ph)Cl] (3) in the triclinic space group P1 witha= 9.389(1),b= 13.629(1),c= 15.218(1) A˚ , a= 70.25(1),b= 73.46(1),c= 83.57(1)and two independent molecules per asymmetric unit (Z= 4). All complexes show a quite similar planar fourfold environment around palladium(II). A negatively charged organic molecule acts as a tridentate ligand and binds to the metal through the pyridine nitrogen, the imine nitrogen and the sulfur atom. A chloride ion occupies the fourth coordination site. The planar complexes stack nearly parallel to one another in the lattice conforming a layered crystal structure. The cytotoxic activity of the thiosemicarbazones and their metal complexes was tested against the MCF-7, TK-10 and UACC-62 human tumor cell lines. The ligands exhibit lower values of GI50and LC50 than the complexes, H2Bz4Ph being the most active with GI50< 0.003lM; LC50= 13.4lM; GI50= 9.3lM, LC50= 12.9lM; GI50< 0.003, LC50= 13.8lM in the MCF-7, TK-10 and UACC-62 cell lines, respectively. Among the complexes, [Pd(2Bz4Ph)Cl] (3) exhibited the lowest values of GI50in the three studied cell lines.
Share