Author | Caixeta, Daniella Mancino da Luz | |
Author | Fialho, Fernanda Moraes Daniel | |
Author | Azevedo, Zina Maria Almeida | |
Author | Collett-Solberg, Paulo Ferrez | |
Author | Villela, Nivaldo Ribeiro | |
Author | Bouskela, Eliete | |
Access date | 2013-07-05T17:39:56Z | |
Available date | 2013-07-05T17:39:56Z | |
Document date | 2013 | |
Citation | CAIXETA, Daniella Mancino da Luz et al. Evaluation of sublingual microcirculation in children with dengue shock. Clinics, v. 68, n. 7, p. 1061-1064, Jul. 2013. | pt_BR |
ISSN | 1807-5932 | |
URI | https://www.arca.fiocruz.br/handle/icict/6656 | |
Language | eng | pt_BR |
Publisher | Universidade de São Paulo. Faculdade de Medicina | pt_BR |
Rights | open access | pt_BR |
Title | Evaluation of sublingual microcirculation in children with dengue shock | pt_BR |
Type | Article | pt_BR |
DOI | 10.6061/clinics/2013(07)26 | |
Abstract | Objective: To report the sublingual microcirculation observed using Sidestream Dark Field imaging in two children with dengue shock. Method: Two children, aged 9 and 10 years, were admitted to the pediatric intensive care unit with dengue shock and multiple organ dysfunction. Sublingual microcirculation was assessed in each patient on the first and second days of shock and was assessed a final time when the patients were no longer in shock (on the day prior to extubation) using Sidestream Dark Field technology. The De Backer score and microvascular flow index were used for the analyses. Results: Both patients had reduced perfused small vessel density in the first two days and showed predominantly intermittent or no microcirculation flow, as demonstrated by a low microvascular flow index. The blood flow in the large vessels was not affected. Prior to the extubation, the microvascular flow index had increased, although the perfused small vessel density remained diminished, suggesting persistent endothelial dysfunction. Conclusions: Severe microcirculation changes may be involved in the pathophysiological mechanisms that lead to the final stages of dengue shock, which is frequently irreversible and associated with high mortality rates. Microcirculatory monitoring may help elucidate the physiopathology of dengue shock and prove useful as a prognostic tool or therapeutic target. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Centro Biomédico. Laboratório de Pesquisas Clínicas e Experimentais em Biologia Vascular (BioVasc). Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | |
Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | |
Affilliation | Universidade do Estado do Rio de Janeiro. Centro Biomédico. Laboratório de Pesquisas Clínicas e Experimentais em Biologia Vascular (BioVasc). Rio de Janeiro, RJ, Brasil. | |
Affilliation | Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Serviço de Anestesiologia. Rio de Janeiro, RJ, Brasil. | |
Affilliation | Universidade do Estado do Rio de Janeiro. Centro Biomédico. Laboratório de Pesquisas Clínicas e Experimentais em Biologia Vascular (BioVasc). Rio de Janeiro, RJ, Brasil. | |
Subject | Dengue Shock | pt_BR |
Subject | Microcirculation | pt_BR |
Subject | Children | pt_BR |
Subject | Sidestream Dark Field Imaging | pt_BR |