Author | Bongertz, Vera | |
Author | Teixeira, Sylvia Lopes Maia | |
Author | Grinsztejn, Beatriz | |
Author | Pilotto, Jose Henrique da Silva | |
Author | Santos, Valdiléa Gonçalves Veloso dos | |
Author | Morgado, Mariza Gonçalves | |
Author | Bastos, Francisco Inácio Pinkusfeld Monteiro | |
Author | Reis, Elaine Priscilla Ouverney | |
Access date | 2010-08-23T16:58:36Z | pt_BR |
Access date | 2010-11-04T14:20:06Z | |
Available date | 2010-11-04T14:20:06Z | |
Available date | 2010-08-23T16:58:36Z | pt_BR |
Document date | 2005 | pt_BR |
Citation | BONGERTZ, Vera et al. Human immunodeficiency virus type 1 neutralization by plasma from B or F genotype infected individuals. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, n. 1, p. 85-89, Feb. 2005. | pt_BR |
ISSN | 0074-0276 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/657 | |
Sponsorship | Financial support: Faperj E-26/170.409/99, CNPq 33530/2000-0 begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting, WHO, Brazilian Ministry of Health | pt_BR |
Language | eng | pt_BR |
Publisher | Fundação Oswaldo Cruz | pt_BR |
Rights | open access | |
Title | Human immunodeficiency virus type 1 neutralization by plasma from B or F genotype infected individuals | pt_BR |
Type | Article | |
Abstract | Anti-human immunodeficiency virus type 1 (HIV-1) “binding antibodies” (antibodies capable of binding to synthetic peptides or proteins) occur throughout HIV-1 infection, are high-titered and highly cross-reactive, as confirmed in this study by analyzing plasma from B and F genotype HIV-1 infected individuals. Plasma from individuals infected with clade F HIV-1 displayed the most frequent cross-reactivity, in high titers, while Bbr plasma showed much higher specificity. Similarly, neutralization of a reference HIV-1 isolate (HIV-1 MN) was more frequently observed by plasma from F than B genotype infected individuals. No significant difference was seen in neutralization susceptibility of primary B, Bbr or F clade HIV-1 by plasma from individuals infected with the classical B (GPGR) or F HIV-1, but Bbr (GWGR) plasma were less likely to neutralize the F genotype primary HIV-1 isolates. The data indicate that both B and F genotype derived vaccines would be equally effective against B and F HIV-1 infection, with a slightly more probable effectiveness for F than B genotype. Although the Bbr variant appears to induce a much more specific humoral immune response, the susceptibility in neutralizing the Brazilian HIV-1 B genotype Bbr variant is similar to that observed with the classical B genotype HIV-1. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Aids e Imunologia Molecular, Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Aids e Imunologia Molecular, Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Aids e Imunologia Molecular, Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Informações Científicas e Tecnológicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Aids e Imunologia Molecular, Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Human Immunodeficiency Virus type 1 | pt_BR |
Subject | Neutralization | pt_BR |
Subject | Genotype | pt_BR |
Subject | Brazil | pt_BR |