Author | Costa, Maria Fernanda Lima | |
Author | Matos, Divane Leite | |
Author | Ribeiro, Antonio Luiz P. | |
Access date | 2013-06-03T19:25:34Z | |
Available date | 2013-06-03T19:25:34Z | |
Document date | 2010 | |
Citation | LIMA COSTA, Maria Fernanda; MATOS, Divane Leite; RIBEIRO, Antonio Luiz. Chagas disease predicts 10-year stroke mortality in community-dwelling elderly (The Bambuí Cohort Study of Aging). Stroke, v. 145, p. 2477-2482, Nov. 2010. | pt_BR |
ISSN | 1524-4628 | |
URI | https://www.arca.fiocruz.br/handle/icict/6548 | |
Language | por | pt_BR |
Publisher | American Heart Association | pt_BR |
Rights | open access | pt_BR |
Title | Chagas Disease Predicts 10-Year Stroke Mortality in Community-Dwelling Elderly The Bambuí Cohort Study of Aging | pt_BR |
Type | Article | pt_BR |
Abstract | Background and Purpose—Previous case– control studies have suggested a causal link between Chagas disease, which is caused by the protozoan Trypanosoma cruzi, and stroke. We investigated the relationship between Chagas disease and long-term stroke mortality in a large community-based cohort of older adults.
Methods—Participants were 1398 (80.3% from total) residents aged _60 years in Bambuí City, Brazil. The end point was death from stroke. Potential confounding variables included age, sex, conventional stroke risk factors, and high sensitive C-reactive protein.
Results—Participants of this study were followed from 1997 to 2007 leading to 9740 person-years of observation. The baseline prevalence of T. cruzi infection was 37.5% and the overall mortality rate from stroke was 4.62 per 1000 person-years. The risk of death from stroke among T. cruzi-infected participants was twice that of those noninfected (adjusted hazard ratio, 2.36; 95% CI, 1.25 to 4.44). A B-type natriuretic peptide level in the top quartile was a strong and independent predictor of stroke mortality among those infected (adjusted hazard ratio, 2.72; 95% CI, 1.25 to 5.91). The presence of both a high B-type natriuretic peptide level and electrocardiographic atrial fibrillation increased the risk of stroke mortality by 11.49 (95% CI, 3.19 to 41.38) in these individuals.
Conclusions—This study provides new evidence supporting a causal link between Chagas disease and stroke. The results also showed that B-type natriuretic peptide alone or in association with atrial fibrillation has prognostic value for stroke mortality in T. cruzi chronically infected older adults | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Hospital das Clínicas. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Hospital das Clínicas. Belo Horizonte, MG, Brasil. | pt_BR |
Subject | Brain natriuretic peptide | pt_BR |
Subject | Stroke mortality | pt_BR |
Subject | Epidemiology | pt_BR |
Subject | Etiology | pt_BR |
Subject | Chagas disease | pt_BR |
Subject | Trypanosoma Cruzi | pt_BR |