Please use this identifier to cite or link to this item:
https://www.arca.fiocruz.br/handle/icict/63905
VACCINE DEVELOPMENT AT THE SPEED OF LIFE
Affilliation
Beckman Coulter Life Science. Indianapolis, IN, United States.
Beckman Coulter Life Science. Indianapolis, IN, United States.
Beckman Coulter Life Science. Indianapolis, IN, United States.
Beckman Coulter Life Science. Indianapolis, IN, United States.
Beckman Coulter Life Science. Indianapolis, IN, United States.
Abstract in Portuguese
Introduction: The immune system is like an orchestra, with cells and soluble factors cytokines,
antibodies, extracellular vesicles (EVs) working together to fight off infections. Vaccines play a crucial
role in supporting the immune system and increasing lifespan. By simplifying and speeding up the vaccine
development process, we can develop new vaccines more efficiently. This is not only important for
emerging infectious diseases but also for conditions like cancer, Alzheimer’s disease, and allergies, and
for specific populations such as infants and the elderly.
Objectives: We propose solutions that can make the vaccine development cycle easier. We will highlight
how our technologies, such as DURAClones for sample treatment and CytoFLEX/Cytobank for flow
cytometry analysis, can add robustness to the measurement of immune responses. Additionally, we will
explore the use of extracellular vesicles (EVs) as a new class of biologics.
Methodology: EVs have the potential to deliver molecules to specific cells and organs, similar to lipid
nanoparticles used in mRNA delivery. We will discuss how CytoFLEX nano can be used to characterize
EVs and how understanding their biology can contribute to their future use.
Results: Lastly, we showcase the benefits of automation in streamlining the screening and manufacturing
of biologics. By automating certain processes, we can increase efficiency and accuracy, ultimately
improving the development of biologics.
Conclusion: Overall, we aim to provide insights into how our solutions can enhance the vaccine
development cycle, from research to manufacturing.
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