Author | Rocha, Verônica de França Diniz | |
Author | Silva, Euclimeire Neves da | |
Author | Azevedo, Jailton | |
Author | Ribeiro, Marcelo Teles | |
Author | Reis, Mitermayer Galvão | |
Author | Barros, Tania Fraga | |
Author | Reis, Joice Neves | |
Access date | 2024-04-24T17:42:01Z | |
Available date | 2024-04-24T17:42:01Z | |
Document date | 2023 | |
Citation | ROCHA, Verônica de França Diniz et al. The impact of COVID-19 on microbiological profile and antibiotic consumption in ICU: a retrospective study in an infectious disease hospital in Brazil. Brazilian Journal of Infectious Diseases, v. 28, n. 1, p. 1-7, 2024. | en_US |
ISSN | 1413-8670 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/63662 | |
Sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).
Fundação de Amparo de Pesquisa do Estado da Bahia (FAPESB).
Instituto Nacional de Pesquisa em Resistência Antimicrobiana (NPRA).
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
Fundação Maria Emília - Bahia, Brasil. | en_US |
Language | eng | en_US |
Publisher | Elsevier | en_US |
Rights | open access | en_US |
Subject in Portuguese | Resistência antimicrobiana | en_US |
Subject in Portuguese | Acinetobacter baumannii | en_US |
Subject in Portuguese | Infecção por SARS-Cov-2 | en_US |
Title | The impact of COVID-19 on microbiological profile and antibiotic consumption in ICU: a retrospective study in an infectious disease hospital in Brazil | en_US |
Type | Article | en_US |
DOI | 10.1016/j.bjid.2023.103705 | |
Abstract | Background: The COVID-19 pandemic has triggered crises in the public health sector that have complex and multifaceted interrelationships with antimicrobial resistance. It is important to evaluate the impact of COVID-19 on microbiological profile, antibiotic and alcohol gel consumption in Intensive Care Units (ICU). Methods: This is a retrospective study undertaken in an infectious disease hospital located in Bahia/Brazil during three periods: from March 2019 to February 2020; from March 2020 to February 2021; and from March 2021 to February 2022. It was evaluated the incidence density of Candida spp and of multidrug-resistant Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species (ESKAPE group) in blood, urine and tracheal secretion isolated 48 h after the patient's admission to the ICU, as well as the use of alcohol gel (in milliliters) and consumption of antibiotics in Defined Daily Dose (DDD) per 1,000 ICU patient-days in the previous year and in the first two years of COVID-19 pandemic. Results: There was an increase in Candida spp. (5.81, p < 0.001, IRR = 10.47, 95 % CI 2.57‒42.62) and in carbapenem-resistant A. baumannii in clinical cultures (4.71, p < 0.001, IRR = 8.46, 95 % CI 2.07‒34.60), the latter mainly in tracheal secretions (3.18, p = 0.02, IRR = 11.47, 95 % CI 1.58‒83.39). A rise in the consumption of ceftriaxone and piperacillin-tazobactam, along with an increase in the utilization of alcohol gel were observed. Conclusion: The shifting microbiological profile can be attributed to both the unique characteristics of patients with COVID-19 and the adjustments made to healthcare facilities' structural and work routines. Understanding these changes is essential in addressing the accelerated impact of antimicrobial resistance during the pandemic. Therefore, conducting thorough reviews of institutional practices and routines becomes critical in mitigating the consequences of antimicrobial resistance and its implications for patient care. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Biotecnologia em Saúde e Medicina Investigativa. Salvador, BA, Brasil / Instituto Couto Maia. Salvador, BA, Brasil. | en_US |
Affilliation | Instituto Couto Maia. Salvador, BA, Brasil. | en_US |
Affilliation | Universidade Federal da Bahia. Instituto de Ciência da Saúde. Salvador, BA, Brasil. | en_US |
Affilliation | Instituto Couto Maia. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Ciência da Saúde. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Yale University. Yale School of Public Health. New Haven, United States. | en_US |
Affilliation | Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil. | en_US |
Subject | Antimicrobial resistance | en_US |
Subject | Acinetobacter baumannii | en_US |
Subject | SARS-Cov-2 infection | en_US |
DeCS | Acinetobacter baumannii | en_US |
DeCS | SARS-CoV-2 | en_US |
DeCS | Infecções | en_US |