Author | Anjos, Rosângela O. | |
Author | Portilho, Moyra M. | |
Author | Nascimento, Leile Camila Jacob | |
Author | Carvalho, Caroline X. | |
Author | Moreira, Patrícia S. S. | |
Author | Sacramento, Gielson A. | |
Author | Nery Junior, Nivison R. R. | |
Author | Oliveira, Daiana de | |
Author | Cruz, Jaqueline S. | |
Author | Cardoso, Cristiane W. | |
Author | Argibay, Hernan D. | |
Author | Plante, Kenneth S. | |
Author | Plante, Jessica A. | |
Author | Weaver, Scott C. | |
Author | Kitron, Uriel D. | |
Author | Reis, Mitermayer G. | |
Author | Ko, Albert I. | |
Author | Costa, Federico | |
Author | Ribeiro, Guilherme S. | |
Access date | 2024-04-22T15:12:05Z | |
Available date | 2024-04-22T15:12:05Z | |
Document date | 2023 | |
Citation | ANJOS, Rosângela O. et al. Dynamics of chikungunya virus transmission in the first year after its introduction in Brazil: a cohort study in an urban community. Plos Neglected Tropical Diseases, v. 17, n. 12, n. 1-17, 2023. | en_US |
ISSN | 1935-2735 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/63620 | |
Sponsorship | Fundação Brasileira Conselho Nacional de Ciência e Tecnologia Desenvolvimento.
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).
Ministério da Educação do Brasil (MEC).
Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB).
US National Institutes of Health (NIAID).
Yale School of Public Health.
Fundação Oswaldo Cruz.
Universidade Federal de Bahia.
Ministério da Saúde do Brasil. Secretaria de Ciência, Tecnologia e Insumos Estratégicos. Departamento de Ciência e Tecnologia. | en_US |
Language | eng | en_US |
Publisher | Public Library of Science | en_US |
Rights | open access | en_US |
Subject in Portuguese | Vírus chikungunya | en_US |
Subject in Portuguese | Transmissão | en_US |
Subject in Portuguese | Estudo de coorte | en_US |
Subject in Portuguese | Comunidade urbana | en_US |
Subject in Portuguese | Brasil | en_US |
Title | Dynamics of chikungunya virus transmission in the first year after its introduction in Brazil: a cohort study in an urban community | en_US |
Type | Article | en_US |
DOI | 10.1371/journal. pntd.0011863 | |
Abstract | Background: The first chikungunya virus (CHIKV) outbreaks during the modern scientific era were identified in the Americas in 2013, reaching high attack rates in Caribbean countries. However, few cohort studies have been performed to characterize the initial dynamics of CHIKV transmission in the New World. Methodology/Principal findings: To describe the dynamics of CHIKV transmission shortly after its introduction in Brazil, we performed semi-annual serosurveys in a long-term community-based cohort of 652 participants aged ≥5 years in Salvador, Brazil, between Feb-Apr/2014 and Nov/2016-Feb/2017. CHIKV infections were detected using an IgG ELISA. Cumulative seroprevalence and seroincidence were estimated and spatial aggregation of cases was investigated. The first CHIKV infections were identified between Feb-Apr/2015 and Aug-Nov/2015 (incidence: 10.7%) and continued to be detected at low incidence in subsequent surveys (1.7% from Aug-Nov/2015 to Mar-May/2016 and 1.2% from Mar-May/2016 to Nov/206-Feb/2017). The cumulative seroprevalence in the last survey reached 13.3%. It was higher among those aged 30–44 and 45–59 years (16.1% and 15.6%, respectively), compared to younger (12.4% and 11.7% in <15 and 15–29 years, respectively) or older (10.3% in ≥60 years) age groups, but the differences were not statistically significant. The cumulative seroprevalence was similar between men (14.7%) and women (12.5%). Yet, among those aged 15–29 years, men were more often infected than women (18.1% vs. 7.4%, respectively, P = 0.01), while for those aged 30–44, a non-significant opposite trend was observed (9.3% vs. 19.0%, respectively, P = 0.12). Three spatial clusters of cases were detected in the study site and an increased likelihood of CHIKV infection was detected among participants who resided with someone with CHIKV IgG antibodies. Conclusions/Significance: Unlike observations in other settings, the initial spread of CHIKV in this large urban center was limited and focal in certain areas, leaving a high proportion of the population susceptible to further outbreaks. Additional investigations are needed to elucidate the factors driving CHIKV spread dynamics, including understanding differences with respect to dengue and Zika viruses, in order to guide prevention and control strategies for coping with future outbreaks. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz, Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz, Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz, Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz, Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz, Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz, Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz, Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz, Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz, Salvador, BA, Brasil. | en_US |
Affilliation | Secretaria Municipal de Saúde de Salvador. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz, Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil. | en_US |
Affilliation | World Reference Center for Emerging Viruses and Arboviruses. University of Texas Medical Branch. Galveston, Texas, United States of America. | en_US |
Affilliation | World Reference Center for Emerging Viruses and Arboviruses. University of Texas Medical Branch. Galveston, Texas, United States of America. | en_US |
Affilliation | World Reference Center for Emerging Viruses and Arboviruses. University of Texas Medical Branch. Galveston, Texas, United States of America. | en_US |
Affilliation | Emory University. Atlanta, Georgia, United States of America. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz, Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Yale University. New Haven, Connecticut, United States of America. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz, Salvador, BA, Brasil / Yale University. New Haven, Connecticut, United States of America. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz, Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Yale University. New Haven, Connecticut, United States of America / University of Liverpool. Liverpool, United Kingdom / Lancaster University. Lancaster, United Kingdom. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz, Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil. | en_US |
Subject | Chikungunya virus | en_US |
Subject | Transmission | en_US |
Subject | Cohort study | en_US |
Subject | Urban community | en_US |
Subject | Brazil | en_US |
DeCS | Vírus chikungunya | en_US |
DeCS | Transmissão de doença infecciosa | en_US |
DeCS | Estudos de coortes | en_US |
DeCS | Brasil | en_US |