Author | Elsas, Maria Ignez Capella Gaspar | |
Author | Joseph, Danielle | |
Author | Xavier-Elsas, Pedro Paulo | |
Author | Vargaftig, B. Boris | |
Access date | 2013-03-07T16:52:02Z | |
Available date | 2013-03-07T16:52:02Z | |
Document date | 1997 | |
Citation | ELSAS, Maria Ignez C. Gaspar et al. Rapid increase in bone-marrow eosinophil production and responses to eosinopoietic interleukins triggered by intranasal allergen challenge. American Journal of Respiratory Cell and Molecular Biology, New York, v. 17, n. 4, p. 404-413, Oct. 1997. | pt_BR |
ISSN | 1044-1549 | |
URI | https://www.arca.fiocruz.br/handle/icict/6355 | |
Sponsorship | INSERM, Institut Pasteur, PAPES/FIOCRUZ, RHAE-UFRJ, CNPq e CAPES-COFECUB. | pt_BR |
Language | eng | pt_BR |
Publisher | American Lung Association | pt_BR |
xmlui.metadata.dc.relation.isbasedon | 1. Sanderson, C. J. 1992. Interleukin-5, eosinophils and disease. Blood 79:3101–
3109. | pt_BR |
xmlui.metadata.dc.relation.isbasedon | 2. Calhoun, W. J., J. Sedgwick, and W. W. Busse. 1991. The role of eosinophils
in the pathophysiology of asthma. Ann. N.Y. Acad. Sci. 629:62–72. | pt_BR |
xmlui.metadata.dc.relation.isbasedon | 3. Kroegel, C., J. C. Virchow, and C. Walker. 1993. Asthma. N. Engl. J. Med.
328:1639–1640. | pt_BR |
xmlui.metadata.dc.relation.isbasedon | 4. Moqbel, R., F. Levi-Schaffer, and A. B. Kay. 1994. Cytokine generation by
eosinophils. J. Allergy Clin. Immunol. 94:1183–1188. | pt_BR |
xmlui.metadata.dc.relation.isbasedon | 5. Kay, A. B. 1992. “Helper” (CD41) T cells and eosinophils in allergy and
asthma. Am. Rev. Respir. Dis. 145:S22-S26. | pt_BR |
xmlui.metadata.dc.relation.isbasedon | Walker, C., J. C. Virchow, P. Bruijnzeel, and K. Blaser. 1991. T-cell subsets
and their soluble products regulate eosinophilia in allergic and nonallergic
asthma. J. Immunol. 146:1829–1835. | pt_BR |
xmlui.metadata.dc.relation.isbasedon | Walker, C., M. K. Kaegi, P. Braun, and K. Blaser. 1991. Activated T cells
and eosinophilia in bronchoalveolar lavages from subjects with asthma
correlated with disease severity. J. Allergy Clin. Immunol. 88:935–942. | pt_BR |
xmlui.metadata.dc.relation.isbasedon | Egan, R. W., D. Athwahl, C.-C. Chou, S. Emtage, C.-H. Jehn, T. T. Kung,
P. J. Mauser, N. J. Murgolo, and M. W. Bodmer. 1995. Inhibition of pulmonary
eosinophilia and hyperreactivity by antibodies to interleukin-5.
Int. Arch. Allergy Immunol. 107:321–322. | pt_BR |
xmlui.metadata.dc.relation.isbasedon | Kung, T. T., D. Stelts, J. A. Zurcher, A. S. Watnick, H. Jones, P. J. Mauser,
X. Fernandez, S. Umland, W. Kreutner, R. W. Chapman, and R. W. Egan.
1994. Mechanisms of allergic pulmonary eosinophilia in the mouse. J. Allergy
Clin. Immunol. 94:1217–1224. | pt_BR |
xmlui.metadata.dc.relation.isbasedon | Nakajima, H., I. Iwamoto, S. Tomoe, R. Matsumura, H. Tomioka, K.
Takatsu, and S. Yoshida. 1992. CD41 T lymphocytes and interleukin-5
mediate antigen-induced eosinophil infiltration into the mouse trachea.
Am. Rev. Respir. Dis. 146:374–377. | pt_BR |
xmlui.metadata.dc.relation.isbasedon | Eum, S.-Y., S. Hailé, J. Lefort, M. Huerre, and B. B. Vargaftig. 1995. Eosinophil
recruitment into the respiratory epithelium following antigenic
challenge in hyper-IgE mice is accompanied by interleukin-5-dependent
bronchial hyperresponsiveness. Proc. Natl. Acad. Sci. USA 92:12290–
12294. | pt_BR |
xmlui.metadata.dc.relation.isbasedon | Denburg, J. A., M. Woolley, R. Ellis, M. Dahlback, and P. O’Byrne. 1995.
Allergen-induced changes in bone marrow progenitors and airway responsiveness
in dogs. Int. Arch. Allergy Immunol. 107:239–241. | pt_BR |
xmlui.metadata.dc.relation.isbasedon | Woolley, M. A., J. A. Denburg, R. Ellis, M. Dahlback, and P. M. O’Byrne.
1994. Allergen-induced changes in bone marrow progenitors and airway
responsiveness in dogs and the effect of inhaled budesonide on these parameters.
Am. J. Respir. Cell Mol. Biol. 11:600–606. | pt_BR |
xmlui.metadata.dc.relation.isbasedon | Strath, M., D. Warren, and C. J. Sanderson. 1985. Detection of eosinophils
using an EPO assay: its use as an assay for eosinophil differentiation factors.
J. Immunol. Methods 83:209–215. | pt_BR |
xmlui.metadata.dc.relation.isbasedon | Zuany-Amorim, C., C. Creminon, M. C. Nevers, M. Nahori, B. B.Vargaftig,
and M. Pretolani. 1996. Modulation by IL-10 of antigen-induced IL-5 generation,
CD41 T-lymphocyte and eosinophil infiltration into the mice
peritoneal cavity. J. Immunol. 157:377–384. | pt_BR |
xmlui.metadata.dc.relation.isbasedon | Chervenick, P. A., D. Zucker-Franklin, and M. A. S. Moore. 1988. In vitro
and in vivo hematopoieis. In Atlas of Blood Cells: Function and Pathology,
2nd ed. D. Zucker-Franklin, M. F. Greaves, C. E. Grossi, and A. M.
Marmont, editors. Edi-Ermes /Lea and Febiger, Milan and Philadelphia.
3–27. | pt_BR |
xmlui.metadata.dc.relation.isbasedon | Bagby, G. C. 1994. Hematopoiesis. In The Molecular Basis of Blood Diseases,
2nd ed. G. Stamatoyannopoulos, A. W. Nienhuis, P. W. Majerus,
and H. Varmus, editors. W. B. Saunders, Philadelphia. 71–106. | pt_BR |
xmlui.metadata.dc.relation.isbasedon | Metcalf, D. 1977. Haematopoietic Colonies: In Vitro Cloning of Normal and
Leukemic Cells. Elsevier-North Holland, Amsterdam. | pt_BR |
xmlui.metadata.dc.relation.isbasedon | Zucker-Franklin, D. 1988. Eosinophils. In Atlas of Blood Cells: Function
and Pathology, 2nd ed. D. Zucker-Franklin, M. F. Greaves, C. E. Grossi,
and A. M. Marmont, editors. Edi-Ermes /Lea and Febiger, Milan and Philadelphia.
257–284. | pt_BR |
xmlui.metadata.dc.relation.isbasedon | Ten, R. M., L. R. Pease, D. J. McKean, M. P. Bell, and G. J. Gleich. 1989.
Molecular cloning of human eosinophil peroxidase: evidence for the existence
of a peroxidase multigene family. J. Exp. Med. 169:1757–1769. | pt_BR |
xmlui.metadata.dc.relation.isbasedon | Horton, M. A., K. A. Larson, J. J. Lee, and N. A. Lee. 1996. Cloning of the
murine eosinophil peroxidase gene (mEPO): characterization of a conserved
subgroup of mammalian hematopoietic peroxidases. J. Leukocyte
Biol. 60:285–294. | pt_BR |
xmlui.metadata.dc.relation.isbasedon | Bach, M., J. Brashler, M. Sanders, and M. Bienkowski. 1991. Pitfalls in the
quantitative estimation of the secretion of granule proteins by eosinophils.
J. Immunol. Methods 142:243–250. | pt_BR |
xmlui.metadata.dc.relation.isbasedon | Gaspar Elsas, M. I. C., P. Xavier Elsas, D. Joseph, N. Havet, L. A. A. Silva,
D.R. Salgado, B. Saliou, and B. B. Vargaftig. 1997. Stimulation of early
eosinophil progenitors by heat stable alveolar macrophage product from
ovalbumin-sensitized and non-sensitized guinea pigs. Clin. Exp. Allergy
27:208–217. | pt_BR |
xmlui.metadata.dc.relation.isbasedon | Metcalf, D. 1993. Hematopoietic regulators: redundancy or subtlety? Blood
82:3515–3523. | pt_BR |
xmlui.metadata.dc.relation.isbasedon | Inman, M. D., J. A. Denburg, R. Ellis, M. Dahlback, and P. M. Byrne. 1996.
Allergen-induced increase in bone marrow progenitors in airway hyperresponsive
dogs: regulation by a serum hemopoietic factor. Am. J. Respir.
Cell Mol. Biol. 15:305–311. | pt_BR |
xmlui.metadata.dc.relation.isbasedon | Rennick, D. M., L. Thomson-Snipes, R. L. Coffman, B. Seymour, J. D.
Jackson, and S. Hudak. 1990. In vivo administration of antibody to interleukin-
5 inhibits increased generation of eosinophils and their progenitors
in bone marrow of parasitized mice. Blood 76:312–316. | pt_BR |
xmlui.metadata.dc.relation.isbasedon | Lefort, J., C. M. Bachelet, D. Leduc, and B. B. Vargaftig. 1996. Effect of antigen
provocation of IL-5 transgenic mice on eosinophil mobilization and
bronchial hyperresponsiveness. J. Allergy Clin. Immunol. 97:788–799. | pt_BR |
Rights | restricted access | pt_BR |
Title | Rapid increase in bone-marrow eosinophil production and responses to eosinopoietic interleukins triggered by intranasal allergen challenge | pt_BR |
Type | Article | pt_BR |
DOI | 10.1165/ajrcmb.17.4.2691 | |
Abstract | To define the effects of immunization and exposure to allergen on the eosinophil lineage, we studied blood and bone-marrow eosinophil numbers, serum interleukin (IL)-5 levels, and eosinophil progenitor and precursor responses to IL-3 and IL-5 in ovalbumin-immunized BALB/c mice after intranasal challenge. Increased blood eosinophilia was found in immune relative to nonimmune mice, but the differences between challenged and unchallenged immune animals were not significant. In contrast, significantly increased circulating levels of IL-5 and numbers of bone-marrow eosinophils were found in sensitized animals exposed to allergen, relative to unchallenged, sensitized controls. An allergen-induced increase in IL-3-sensitive progenitors yielding eosinophil-bearing colonies was also found at 2 h after challenge. Furthermore, an eosinophil differentiation assay showed a marked increase in the magnitude of the responses to IL-5 and IL-3 over a 7-day period in bone-marrow cells of sensitized animals, which was detectable at 24 h after allergen challenge, but not at 2 h and not in unchallenged controls. Modulation of the responses of bone-marrow cells to IL-5 is induced by a circulating factor present in challenged immune animals, as shown by in vivo plasma transfer, but is at best only partly blocked by in vivo treatment with the anti-IL-5 antibody TRFK-5. These data indicate that allergen challenge in the airways leads to rapid long-term modifications in bone-marrow eosinophil progenitors and precursors, and that increased responses to eosinopoietins in bone marrow depend on the release, between 2 h and 24 h after challenge, of a circulating factor distinct from IL-5. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Pesquisa. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Pesquisa. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Institut Pasteur. Unité de Pharmacologie Cellulaire. Paris. France. | pt_BR |
Subject | Alérgenos | |
Subject | Células da Medula Óssea | |
Subject | Eosinófilos | |
Subject | Interleucina-5 | |
DeCS | Alérgenos | pt_BR |
DeCS | Células da Medula Óssea | pt_BR |
DeCS | Eosinófilos | pt_BR |
DeCS | Interleucina-5 | pt_BR |
Embargo date | 2030-12-31 | |