Author | Veras, Patrícia Sampaio Tavares | |
Author | Santana, Maria Borges Rabêlo de | |
Author | Brodskyn, Claudia Ida | |
Author | Fraga, Deborah Bittencourt Mothé | |
Author | Solcà, Manuela Silva | |
Author | Menezes, Juliana Perrone Bezerra de | |
Author | Leite, Bruna Martins Macedo | |
Author | Teixeira, Helena Mariana Pitangueira | |
Access date | 2024-04-04T15:21:55Z | |
Available date | 2024-04-04T15:21:55Z | |
Document date | 2023 | |
Citation | VERAS, Patrícia Sampaio Tavares et al. Elucidating the role played by bone marrow in visceral leishmaniasis. Frontiers in Cellular and Infection Microbiology, v. 13, p. 1-13, 2023 | en_US |
ISSN | 2235-2988 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/63384 | |
Sponsorship | Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB).
Instituto Gonçalo Moniz-FIOCRUZ Bahia.
Conselho Nacional de Pesquisa Científica e Desenvolvimento Tecnológico (CNPq).
Fundação de Apoio à Fiocruz (FIOTEC).
Programa Fiocruz Inova.
Conselho de Pessoal de Nível Superior – Brasil (CAPES). | en_US |
Language | eng | en_US |
Publisher | Frontiers Media | en_US |
Rights | open access | en_US |
Subject in Portuguese | Leishmaniose visceral | en_US |
Subject in Portuguese | Medula óssea | en_US |
Subject in Portuguese | Leishmania | en_US |
Subject in Portuguese | Leishmaniose visceral humana | en_US |
Subject in Portuguese | Leishmaniose visceral canina | en_US |
Title | Elucidating the role played by bone marrow in visceral leishmaniasis | en_US |
Type | Article | en_US |
DOI | 10.3389/fcimb.2023.1261074 | |
Abstract | Leishmaniasis is a widespread group of infectious diseases that significantly impact global health. Despite high prevalence, leishmaniasis often receives inadequate attention in the prioritization of measures targeting tropical diseases. The causative agents of leishmaniasis are protozoan parasites of the Leishmania genus, which give rise to a diverse range of clinical manifestations, including cutaneous and visceral forms. Visceral leishmaniasis (VL), the most severe form, can be life-threatening if left untreated. Parasites can spread systemically within the body, infecting a range of organs, such as the liver, spleen, bone marrow and lymph nodes. Natural reservoirs for these protozoa include rodents, dogs, foxes, jackals, and wolves, with dogs serving as the primary urban reservoir for Leishmania infantum. Dogs exhibit clinical and pathological similarities to human VL and are valuable models for studying disease progression. Both human and canine VL provoke clinical symptoms, such as organ enlargement, fever, weight loss and abnormal gamma globulin levels. Hematologic abnormalities have also been observed, including anemia, leukopenia with lymphocytosis, neutropenia, and thrombocytopenia. Studies in dogs have linked these hematologic changes in peripheral blood to alterations in the bone marrow. Mouse models of VL have also contributed significantly to our understanding of the mechanisms underlying these hematologic and bone marrow abnormalities. This review consolidates information on hematological and immunological changes in the bone marrow of humans, dogs, and mice infected with Leishmania species causing VL. It includes findings on the role of bone marrow as a source of parasite persistence in internal organs and VL development. Highlighting gaps in current knowledge, the review emphasizes the need for future research to enhance our understanding of VL and identify potential targets for novel diagnostic and therapeutic approaches. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Parasitas - Interação Hospedeiro e Epidemiologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Conselho Nacional de Pesquisa e Desenvolvimento Científico. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Parasitas - Interação Hospedeiro e Epidemiologia. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Parasitas - Interação Hospedeiro e Epidemiologia. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Parasitas - Interação Hospedeiro e Epidemiologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina Veterinária e Zootecnia. Departamento de Medicina Veterinária Preventiva e Produção Animal. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Parasitas - Interação Hospedeiro e Epidemiologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina Veterinária e Zootecnia. Departamento de Medicina Veterinária Preventiva e Produção Animal. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Parasitas - Interação Hospedeiro e Epidemiologia. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Parasitas - Interação Hospedeiro e Epidemiologia. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Parasitas - Interação Hospedeiro e Epidemiologia. Salvador, BA, Brasil. | en_US |
Subject | Visceral leishmaniasis | en_US |
Subject | Bone marrow | en_US |
Subject | Leishmania | en_US |
Subject | Human visceral leishmaniasis | en_US |
Subject | Canine visceral leishmaniasis | en_US |
DeCS | Leishmaniose visceral | en_US |
DeCS | Medula óssea | en_US |
DeCS | Leishmania | en_US |