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LEISHMANIASES OF THE NEW WORLD: CURRENT CONCEPTS AND IMPLICATIONS FOR FUTURE RESEARCH
Americas
New world
Leishmanial infection
Clinical forms
Immunology
Pathology
Laboratory diagnosis
Treatment
Epidemiology
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.
Yale University. School of Medicine. Department of Epidemiology and Public Health. New Haven, CT, USA.
Yale University. School of Medicine. Department of Epidemiology and Public Health. New Haven, CT, USA.
Abstract
Recent epidemiologic studies indicate that leishmaniasis in the Americas is far more abundant and of greater public health importance than was previously recognized. The disease in the New World is caused by a number of different parasite species that are capable of producing a wide variety of clinical manifestations. The outcome of leishmanial infection in humans is largely dependent on the immune responsiveness of the host and the virulence of the infecting parasite strain. This article reviews current concepts of the clinical forms, immunology, pathology, laboratory diagnosis, and treatment of the disease as well as aspects of its epidemiology and control. Recommendations for future research on the disease and its control are made.
Keywords
LeishmaniasisAmericas
New world
Leishmanial infection
Clinical forms
Immunology
Pathology
Laboratory diagnosis
Treatment
Epidemiology
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