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UPPER AIRWAY MUCOCILIARY CLEARANCE IS IMPAIRED IN DYSPNEIC COVID‑19 PATIENTS
Author
Affilliation
University of Sao Paulo. Departament of Ophathalmology and Otorhinolaryngology. São Paulo, SP, Brazil / University of British Columbia. Centre of Heart Lung Innovation. Vancouver, BC, Canada / Federal University of São Paulo. Department of Otorhinolaryngology and Head and Neck Surgery. São Paulo, SP, Brazil.
University of British Columbia. Centre of Heart Lung Innovation. Vancouver, BC, Canada / Federal University of São Paulo. Department of Otorhinolaryngology and Head and Neck Surgery. São Paulo, SP, Brazil.
Federal University of São Paulo. Department of Otorhinolaryngology and Head and Neck Surgery. São Paulo, SP, Brazil / Escola Superior de Bombeiros. Polícia Militar de São Paulo. Franco da Rocha, SP, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.
University of British Columbia. Centre of Heart Lung Innovation. Vancouver, BC, Canada.
University of British Columbia. Centre of Heart Lung Innovation. Vancouver, BC, Canada.
University of Sao Paulo. Departament of Ophathalmology and Otorhinolaryngology. São Paulo, SP, Brazil.
University of British Columbia. Centre of Heart Lung Innovation. Vancouver, BC, Canada / Federal University of São Paulo. Department of Otorhinolaryngology and Head and Neck Surgery. São Paulo, SP, Brazil.
Federal University of São Paulo. Department of Otorhinolaryngology and Head and Neck Surgery. São Paulo, SP, Brazil / Escola Superior de Bombeiros. Polícia Militar de São Paulo. Franco da Rocha, SP, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.
University of British Columbia. Centre of Heart Lung Innovation. Vancouver, BC, Canada.
University of British Columbia. Centre of Heart Lung Innovation. Vancouver, BC, Canada.
University of Sao Paulo. Departament of Ophathalmology and Otorhinolaryngology. São Paulo, SP, Brazil.
Abstract
Covid-19 is transmitted mainly by respiratory droplets and as the upper airway mucosa is the first innate immune barrier, it is crucial to understand the effects of SARS-CoV-2 on this system. In the current study, we aimed to evaluate the nasal mucociliary clearance in patients with SARS-CoV-2 infection and their symptom development. Observational cross-sectional study. The nasal mucociliary clearance (NMC) time was evaluated by the saccharin test and the results were compared between patients with SARS-CoV-2 infection (group 1) and controls (group 2, asymptomatic patients with a negative polymerase chain reaction test). We also compared the NMC time for each specific symptom suffered by participants in group 1 with the NMC time of the control group as well as with the patients in group 1 who were asymptomatic. There was a significant increase in NMC time in group 1 with dyspnea when compared to the control group (p = 0.032) and also when compared to patients who were infected were not dyspneic (p = 0.04). There were no differences in the clearance times when considering other symptoms. COVID-19 patients with dyspnea present with altered nasal mucociliary clearance.
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