Author | Moll-Bernardes, Renata | |
Author | Ferreira, Juliana R. | |
Author | Sousa, Andréa Silvestre | |
Author | Tortelly, Mariana B. | |
Author | Pimentel, Adriana L. | |
Author | Figueiredo, Ana Cristina B. S. | |
Author | Schaustz, Eduardo B. | |
Author | Secco, José Carlos Pizzolante | |
Author | Sales, Allan Robson Kluser | |
Author | Terzi, Flavia V. O. | |
Author | Brito, Adriana Xavier de | |
Author | Sarmento, Renée O. | |
Author | Noya-Rabelo, Marcia M. | |
Author | Fortier, Sergio | |
Author | Silva, Flavia A. Matos e | |
Author | Vera, Narendra | |
Author | Conde, Luciana | |
Author | Cabral-Castro, Mauro Jorge | |
Author | Albuquerque, Denilson C. | |
Author | de-Castro, Paulo Rosado | |
Author | Camargo, Gabriel C. | |
Author | Pinheiro, Martha V. T. | |
Author | Souza, Olga F. | |
Author | Bozza, Fernando A. | |
Author | Luiz, Ronir R. | |
Author | Medei, Emiliano | |
Access date | 2024-02-20T23:49:58Z | |
Available date | 2024-02-20T23:49:58Z | |
Document date | 2023 | |
Citation | MOLL-BERNARDES, Renata et al. Impact of the immune profiles of hypertensive patients with and without obesity on COVID-19 severity. International Journal of Obesity, v. 48, n. 2, p. 254-262, Feb. 2023. | en_US |
ISSN | 0307-0565 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/62709 | |
Language | eng | en_US |
Publisher | Springer Nature | en_US |
Rights | restricted access | en_US |
Title | Impact of the immune profiles of hypertensive patients with and without obesity on COVID-19 severity | en_US |
Type | Article | en_US |
DOI | 10.1038/s41366-023-01407-0 | |
Abstract | Background: Comorbidities such as obesity, hypertension, and diabetes are associated with COVID-19 development and severity, probably due to immune dysregulation; however, the mechanisms underlying these associations are not clear. The immune signatures of hypertensive patients with obesity with COVID-19 may provide new insight into the mechanisms of immune dysregulation and progression to severe disease in these patients. Methods: Hypertensive patients were selected prospectively from a multicenter registry of adults hospitalized with COVID-19 and stratified according to obesity (BMI ≥ 30 kg/m²). Clinical data including baseline characteristics, complications, treatment, and 46 immune markers were compared between groups. Logistic regression was performed to identify variables associated with the risk of COVID-19 progression in each group. Results: The sample comprised 213 patients (89 with and 124 without obesity). The clinical profiles of patients with and without obesity differed, suggesting potential interactions with COVID-19 severity. Relative to patients without obesity, patients with obesity were younger and fewer had cardiac disease and myocardial injury. Patients with obesity had higher EGF, GCSF, GMCSF, interleukin (IL)-1ra, IL-5, IL-7, IL-8, IL-15, IL-1β, MCP 1, and VEGF levels, total lymphocyte counts, and CD8+ CD38+ mean fluorescence intensity (MFI), and lower NK-NKG2A MFI and percentage of CD8+ CD38+ T cells. Significant correlations between cytokine and immune cell expression were observed in both groups. Five variables best predicted progression to severe COVID-19 in patients with obesity: diabetes, the EGF, IL-10, and IL-13 levels, and the percentage of CD8+ HLA-DR+ CD38+ cells. Three variables were predictive for patients without obesity: myocardial injury and the percentages of B lymphocytes and HLA-DR+ CD38+ cells. Conclusion: Our findings suggest that clinical and immune variables and obesity interact synergistically to increase the COVID-19 progression risk. The immune signatures of hypertensive patients with and without obesity severe COVID-19 highlight differences in immune dysregulation mechanisms, with potential therapeutic applications. | en_US |
Affilliation | D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Rede D’Or São Luiz. Cardiology and Internal Medicine Department. São Paulo, SP,Brazil. | en_US |
Affilliation | D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Disease. Clinical Research Laboratory in Intensive Medicine. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Rede D’Or São Luiz. Cardiology and Internal Medicine Department. São Paulo, SP, Brazil. | en_US |
Affilliation | D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Rede D’Or São Luiz. Cardiology and Internal Medicine Department. São Paulo, SP, Brazil. | en_US |
Affilliation | D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Rede D’Or São Luiz. Cardiology and Internal Medicine Department. São Paulo, SP, Brazil. | en_US |
Affilliation | D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Rede D’Or São Luiz. Cardiology and Internal Medicine Department. São Paulo, SP, Brazil. | en_US |
Affilliation | D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Rio de Janeiro Federal State University. Internal Medicine Department. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Rede D’Or São Luiz. Cardiology and Internal Medicine Department. São Paulo, SP, Brazil / Bahia School of Medicine and Public Health. Salvador, BA, Brazil. | en_US |
Affilliation | D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Federal University of Rio de Janeiro. Institute of Biophysics Carlos Chagas Filho,. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Bahia School of Medicine and Public Health. Salvador, BA, Brazil. | en_US |
Affilliation | Federal University of Rio de Janeiro. Institute of Microbiology Paulo de Góes. Rio de Janeiro, RJ, Brazil / Fluminense Federal University. Faculty of Medicine. Department of Pathology. Niterói, RJ, Brazil. | en_US |
Affilliation | D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Rio de Janeiro State University. Cardiology Department. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Rede D’Or São Luiz. Cardiology and Internal Medicine Department. São Paulo, SP, Brazil. | en_US |
Affilliation | D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Disease. Clinical Research Laboratory in Intensive Medicine. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Institute for Studies in Public Health. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. National Center for Structural Biology and Bioimaging. Rio de Janeiro, RJ, Brazil. | en_US |
Subject | Comorbidities | en_US |
Subject | Obesity | en_US |
Subject | Hypertension | en_US |
Subject | Diabetes | en_US |
Subject | COVID-19 | |
e-ISSN | 1476-5497 | |
Embargo date | 2030-12-31 | |