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https://www.arca.fiocruz.br/handle/icict/62683
GENOME-WIDE STUDY INVESTIGATING EFFECTOR GENES AND POLYGENIC PREDICTION FOR KIDNEY FUNCTION IN PERSONS WITH ANCESTRY FROM AFRICA AND THE AMERICAS
Chronic kidney disease
eGFR
Fine-mapping
Expression quantitative trait locus
Genome-wide association study
Kidney function
Multi-ancestry
Polygenic scores
Author
Hughes, Odessica
Bentley, Amy R.
Breeze, Charles L.
Aguet, Francois
Xu, Xiaoguang
Nadkarni, Girish
Sun, Quan
Lin, Bridget M.
Gilliland, Thomas
Meyer, Mariah C.
Du, Jiawen
Raffield, Laura M.
Kramer, Holly
Morton, Robert W.
Gouveia, Mateus H.
Atkinson, Elizabeth G.
Valladares-Salgado, Adan
Wacher-Rodarte, Niels
Dueker, Nicole D.
Guo, Xiuqing
Hai, Yang
Adeyemo, Adebowale
Best, Lyle G.
Cai, Jianwen
Chen, Guanjie
Chong, Michael
Doumatey, Ayo
Eales, James
Goodarzi, Mark O.
Ipp, Eli
Irvin, Marguerite Ryan
Jiang, Minzhi
Jones, Alana C.
Kooperberg, Charles
Krieger, Jose E.
Lange, Ethan M.
Lanktree, Matthew B.
Lash, James P.
Lotufo, Paulo A.
Loos, Ruth J. F.
My, Vy Thi Ha
Peralta-Romero, Jesús
Qi, Lihong
Raffel, Leslie J.
Rich, Stephen S.
Rodriquez, Erik J.
Tarazona-Santos, Eduardo
Taylor, Kent D.
Umans, Jason G.
Wen, Jia
Young, Bessie A.
Yu, Zhi
Zhang, Ying
Chen, Yii-Der Ida
Rundek, Tanja
Rotter, Jerome I.
Cruz, Miguel
Fornage, Myriam
Costa, Maria Fernanda Furtado Lima
Pereira, Alexandre C.
Paré, Guillaume
Natarajan, Pradeep
Cole, Shelley A.
Carson, April P.
Lange, Leslie A.
Li, Yun
Perez-Stable, Eliseo J.
Do, Ron
Charchar, Fadi J.
Tomaszewski, Maciej
Rotimi, Charles
Morris, Andrew P.
Franceschini, Nora
Bentley, Amy R.
Breeze, Charles L.
Aguet, Francois
Xu, Xiaoguang
Nadkarni, Girish
Sun, Quan
Lin, Bridget M.
Gilliland, Thomas
Meyer, Mariah C.
Du, Jiawen
Raffield, Laura M.
Kramer, Holly
Morton, Robert W.
Gouveia, Mateus H.
Atkinson, Elizabeth G.
Valladares-Salgado, Adan
Wacher-Rodarte, Niels
Dueker, Nicole D.
Guo, Xiuqing
Hai, Yang
Adeyemo, Adebowale
Best, Lyle G.
Cai, Jianwen
Chen, Guanjie
Chong, Michael
Doumatey, Ayo
Eales, James
Goodarzi, Mark O.
Ipp, Eli
Irvin, Marguerite Ryan
Jiang, Minzhi
Jones, Alana C.
Kooperberg, Charles
Krieger, Jose E.
Lange, Ethan M.
Lanktree, Matthew B.
Lash, James P.
Lotufo, Paulo A.
Loos, Ruth J. F.
My, Vy Thi Ha
Peralta-Romero, Jesús
Qi, Lihong
Raffel, Leslie J.
Rich, Stephen S.
Rodriquez, Erik J.
Tarazona-Santos, Eduardo
Taylor, Kent D.
Umans, Jason G.
Wen, Jia
Young, Bessie A.
Yu, Zhi
Zhang, Ying
Chen, Yii-Der Ida
Rundek, Tanja
Rotter, Jerome I.
Cruz, Miguel
Fornage, Myriam
Costa, Maria Fernanda Furtado Lima
Pereira, Alexandre C.
Paré, Guillaume
Natarajan, Pradeep
Cole, Shelley A.
Carson, April P.
Lange, Leslie A.
Li, Yun
Perez-Stable, Eliseo J.
Do, Ron
Charchar, Fadi J.
Tomaszewski, Maciej
Rotimi, Charles
Morris, Andrew P.
Franceschini, Nora
Affilliation
Centre for Genetics and Genomics Versus Arthritis. Centre for Musculoskeletal Research. The University of Manchester. Manchester, UK.
Center for Research on Genomics and Global Health. National Human Genome Research Institute. National Institutes of Health. Bethesda, MD, USA.
Division of Cancer Epidemiology and Genetics. National Cancer Institute. National Institutes of Health. Department Health and Human Services. Bethesda, MD, USA / UCL Cancer Institute. University College London. London, UK.
The Broad Institute of MIT and Harvard. Cambridge, MA, USA.
Division of Cardiovascular Sciences. Faculty of Biology, Medicine, and Health. The University of Manchester. Manchester, UK.
The Charles Bronfman Institute of Personalized Medicine. Icahn School of Medicine at Mount Sinai. New York, NY, USA.
Department of Biostatistics. University of North Carolina at Chapel Hill. Chapel Hill, NC, USA.
Department of Biostatistics. University of North Carolina at Chapel Hill. Chapel Hill, NC, USA.
Cardiovascular Research Center and Center for Genomic Medicine. Massachusetts General Hospital. Boston, MA, USA / Program in Medical and Population Genetics and the Cardiovascular Disease Initiative. Broad Institute. Cambridge, MA, USA / Department of Medicine. Harvard Medical School. Boston, MA, USA.
Department of Biomedical Informatics. University of Colorado Anschutz Medical Campus. Aurora, CO, USA.
Department of Biostatistics. University of North Carolina at Chapel Hill. Chapel Hill, NC, USA.
Department of Genetics. University of North Carolina at Chapel Hill. Chapel Hill, NC, USA.
Division of Nephrology and Hypertension. Loyola University Chicago. Maywood, IL, USA.
Population Health Research Institute. Hamilton, ON, Canada / Department of Pathology and Molecular Medicine. McMaster University. Hamilton, ON, Canada.
Center for Research on Genomics and Global Health. National Human Genome Research Institute. National Institutes of Health. Bethesda, MD, USA.
Department of Molecular and Human Genetics. Baylor College of Medicine. Houston, TX, USA.
Unidad de Investigación Médica en Bioquímica. Hospital de Especialidades. Centro Médico Nacional Siglo XXI. Instituto Mexicano del Seguro Social. Mexico City, Mexico.
Unidad de Investigación Médica en Epidemiologia Clínica. Hospital de Especialidades. Centro Médico Nacional Siglo XXI. Instituto Mexicano del Seguro Social. Mexico City, Mexico.
John P Hussman Institute for Human Genomics. University of Miami Miller School of Medicine. Miami, FL, USA.
The Institute for Translational Genomics and Population Sciences. Department of Pediatrics. The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center. Torrance, CA USA.
The Institute for Translational Genomics and Population Sciences. Department of Pediatrics. The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center. Torrance, CA USA.
Center for Research on Genomics and Global Health. National Human Genome Research Institute. National Institutes of Health. Bethesda, MD, USA.
Missouri Breaks Industries Research Inc. Eagle Butte, SD, USA.
Department of Biostatistics. University of North Carolina at Chapel Hill. Chapel Hill, NC, USA.
Center for Research on Genomics and Global Health. National Human Genome Research Institute. National Institutes of Health. Bethesda, MD, USA.
Population Health Research Institute. Hamilton, ON, Canada / Department of Pathology and Molecular Medicine. McMaster University. Hamilton, ON, Canada.
Center for Research on Genomics and Global Health. National Human Genome Research Institute. National Institutes of Health. Bethesda, MD, USA.
Division of Cardiovascular Sciences. Faculty of Biology, Medicine, and Health. The University of Manchester. Manchester, UK.
Division of Endocrinology, Diabetes, and Metabolism. Department of Medicine. Cedars-Sinai Medical Center. Los Angeles, CA, USA.
Division of Endocrinology and Metabolism. Department of Medicine. The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center. Torrance, CA, USA.
Department of Epidemiology. University of Alabama at Birmingham. Birmingham, AL, USA.
Department of Applied Physical Sciences. University of North Carolina at Chapel Hill. Chapel Hill, NC, USA.
Department of Epidemiology. University of Alabama at Birmingham. Birmingham, AL, USA.
Division of Public Health Sciences. Fred Hutchinson Cancer Center. Seattle, WA, USA.
Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. Instituto do Coração. Laboratório de Genética e Cardiologia Molecular. São Paulo, SP, Brazil.
Department of Biomedical Informatics. University of Colorado Anschutz Medical Campus. Aurora, CO, USA.
Division of Nephrology. Department of Medicine. McMaster University. Hamilton, ON, Canada.
Division of Nephrology. Department of Medicine. University of Illinois. Chicago, IL, USA.
Center for Clinical and Epidemiological Research. Hospital Universitário. Universidade de São Paulo. São Paulo, SP, Brazil.
The Charles Bronfman Institute of Personalized Medicine. Icahn School of Medicine at Mount Sinai. New York, NY, USA / Novo Nordisk Foundation Center for Basic Metabolic Research. Faculty of Health and Medical Sciences. University of Copenhagen. Copenhagen, Denmark.
The Charles Bronfman Institute of Personalized Medicine. Icahn School of Medicine at Mount Sinai. New York, NY, USA.
Unidad de Investigación Médica en Bioquímica. Hospital de Especialidades. Centro Médico Nacional Siglo XXI. Instituto Mexicano del Seguro Social. Mexico City, Mexico.
Department of Public Health Sciences. School of Medicine. University of California Davis. Davis, CA, USA.
Department of Pediatrics. Genetic and Genomic Medicine. University of California. Irvine, Irvine, CA, USA.
Center for Public Health Genomics, University of Virginia. Charlottesville, VA, USA.
Division of Intramural Research, National Heart, Lung, and Blood Institute. National Institutes of Health. Bethesda, MD, USA.
Departamento de Genética, Ecologia e Evolução. Instituto de Ciências Biológicas. Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
The Institute for Translational Genomics and Population Sciences. Department of Pediatrics. The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center. Torrance, CA USA.
MedStar Health Research Institute. Hyattsville MD and Georgetown-Howard Universities Center for Clinical and Translational Science. Washington, DC, USA.
Department of Genetics. University of North Carolina at Chapel Hill. Chapel Hill, NC, USA.
University of Washington School of Medicine. Seattle, WA, USA / Office of Healthcare Equity. UW Justice, Equity, Diversity, and Inclusion Center for Transformational Research. University of Washington. Seattle, WA, USA / Division of Nephrology. Department of Medicine. University of Washington. Seattle, WA, USA / Kidney Research Institute. Department of Medicine. University of Washington. Seattle, WA, USA.
Cardiovascular Research Center and Center for Genomic Medicine. Massachusetts General Hospital. Boston, MA, USA/Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute, Cambridge, MA, USA.
Center for American Indian Health Research. Department of Biostatistics and Epidemiology. Hudson College of Public Health. The University of Oklahoma Health Sciences Center. Oklahoma, OK, USA.
The Institute for Translational Genomics and Population Sciences. Department of Pediatrics. The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center. Torrance, CA USA
Department of Neurology. Epidemiology and Public Health. Miller School of Medicine. University of Miami. Miami, FL, USA.
The Institute for Translational Genomics and Population Sciences. Department of Pediatrics. The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center. Torrance, CA, USA.
Unidad de Investigación Médica en Bioquímica. Hospital de Especialidades. Centro Médico Nacional Siglo XXI. Instituto Mexicano del Seguro Social. Mexico City, Mexico.
Brown Foundation Institute of Molecular Medicine. Houston, TX, USA.
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.
Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. Instituto do Coração. Laboratório de Genética e Cardiologia Molecular. São Paulo, SP, Brazil / Aging Division, Brigham Women's Hospital, Department of Medicine, Harvard Medical School, Boston, MA, USA.
Population Health Research Institute. Hamilton, ON, Canada / Department of Pathology and Molecular Medicine. McMaster University. Hamilton, ON, Canada.
Cardiovascular Research Center and Center for Genomic Medicine. Massachusetts General Hospital. Boston, MA, USA / Program in Medical and Population Genetics and the Cardiovascular Disease Initiative. Broad Institute. Cambridge, MA, USA / Department of Medicine. Harvard Medical School. Boston, MA, USA.
Texas Biomedical Research Institute. San Antonio, TX, USA.
Department of Medicine. University of Mississippi Medical Center. Jackson, MS, USA.
Department of Biomedical Informatics. University of Colorado Anschutz Medical Campus. Aurora, CO, USA.
Center for Research on Genomics and Global Health. National Human Genome Research Institute. National Institutes of Health. Bethesda, MD, USA.
National Institute on Minority Health and Health Disparities. National Institutes of Health. Bethesda, MD, USA.
The Charles Bronfman Institute of Personalized Medicine. Icahn School of Medicine at Mount Sinai. New York, NY, USA.
School of Science, Psychology and Sport. Federation University. Ballarat, VIC, Australia/Department of Cardiovascular Sciences. University of Leicester.
Division of Cardiovascular Sciences. Faculty of Biology, Medicine, and Health. The University of Manchester. Manchester, UK / Manchester Royal Infirmary. Manchester University NHS Foundation Trust. Manchester Academic Health Science Centre. Manchester, UK.
Department of Public Health Sciences. School of Medicine. University of California Davis. Davis, CA, USA.
Centre for Genetics and Genomics Versus Arthritis. Centre for Musculoskeletal Research. The University of Manchester. Manchester, UK.
Department of Epidemiology. University of North Carolina at Chapel Hill. Chapel Hill, NC, USA.
Center for Research on Genomics and Global Health. National Human Genome Research Institute. National Institutes of Health. Bethesda, MD, USA.
Division of Cancer Epidemiology and Genetics. National Cancer Institute. National Institutes of Health. Department Health and Human Services. Bethesda, MD, USA / UCL Cancer Institute. University College London. London, UK.
The Broad Institute of MIT and Harvard. Cambridge, MA, USA.
Division of Cardiovascular Sciences. Faculty of Biology, Medicine, and Health. The University of Manchester. Manchester, UK.
The Charles Bronfman Institute of Personalized Medicine. Icahn School of Medicine at Mount Sinai. New York, NY, USA.
Department of Biostatistics. University of North Carolina at Chapel Hill. Chapel Hill, NC, USA.
Department of Biostatistics. University of North Carolina at Chapel Hill. Chapel Hill, NC, USA.
Cardiovascular Research Center and Center for Genomic Medicine. Massachusetts General Hospital. Boston, MA, USA / Program in Medical and Population Genetics and the Cardiovascular Disease Initiative. Broad Institute. Cambridge, MA, USA / Department of Medicine. Harvard Medical School. Boston, MA, USA.
Department of Biomedical Informatics. University of Colorado Anschutz Medical Campus. Aurora, CO, USA.
Department of Biostatistics. University of North Carolina at Chapel Hill. Chapel Hill, NC, USA.
Department of Genetics. University of North Carolina at Chapel Hill. Chapel Hill, NC, USA.
Division of Nephrology and Hypertension. Loyola University Chicago. Maywood, IL, USA.
Population Health Research Institute. Hamilton, ON, Canada / Department of Pathology and Molecular Medicine. McMaster University. Hamilton, ON, Canada.
Center for Research on Genomics and Global Health. National Human Genome Research Institute. National Institutes of Health. Bethesda, MD, USA.
Department of Molecular and Human Genetics. Baylor College of Medicine. Houston, TX, USA.
Unidad de Investigación Médica en Bioquímica. Hospital de Especialidades. Centro Médico Nacional Siglo XXI. Instituto Mexicano del Seguro Social. Mexico City, Mexico.
Unidad de Investigación Médica en Epidemiologia Clínica. Hospital de Especialidades. Centro Médico Nacional Siglo XXI. Instituto Mexicano del Seguro Social. Mexico City, Mexico.
John P Hussman Institute for Human Genomics. University of Miami Miller School of Medicine. Miami, FL, USA.
The Institute for Translational Genomics and Population Sciences. Department of Pediatrics. The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center. Torrance, CA USA.
The Institute for Translational Genomics and Population Sciences. Department of Pediatrics. The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center. Torrance, CA USA.
Center for Research on Genomics and Global Health. National Human Genome Research Institute. National Institutes of Health. Bethesda, MD, USA.
Missouri Breaks Industries Research Inc. Eagle Butte, SD, USA.
Department of Biostatistics. University of North Carolina at Chapel Hill. Chapel Hill, NC, USA.
Center for Research on Genomics and Global Health. National Human Genome Research Institute. National Institutes of Health. Bethesda, MD, USA.
Population Health Research Institute. Hamilton, ON, Canada / Department of Pathology and Molecular Medicine. McMaster University. Hamilton, ON, Canada.
Center for Research on Genomics and Global Health. National Human Genome Research Institute. National Institutes of Health. Bethesda, MD, USA.
Division of Cardiovascular Sciences. Faculty of Biology, Medicine, and Health. The University of Manchester. Manchester, UK.
Division of Endocrinology, Diabetes, and Metabolism. Department of Medicine. Cedars-Sinai Medical Center. Los Angeles, CA, USA.
Division of Endocrinology and Metabolism. Department of Medicine. The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center. Torrance, CA, USA.
Department of Epidemiology. University of Alabama at Birmingham. Birmingham, AL, USA.
Department of Applied Physical Sciences. University of North Carolina at Chapel Hill. Chapel Hill, NC, USA.
Department of Epidemiology. University of Alabama at Birmingham. Birmingham, AL, USA.
Division of Public Health Sciences. Fred Hutchinson Cancer Center. Seattle, WA, USA.
Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. Instituto do Coração. Laboratório de Genética e Cardiologia Molecular. São Paulo, SP, Brazil.
Department of Biomedical Informatics. University of Colorado Anschutz Medical Campus. Aurora, CO, USA.
Division of Nephrology. Department of Medicine. McMaster University. Hamilton, ON, Canada.
Division of Nephrology. Department of Medicine. University of Illinois. Chicago, IL, USA.
Center for Clinical and Epidemiological Research. Hospital Universitário. Universidade de São Paulo. São Paulo, SP, Brazil.
The Charles Bronfman Institute of Personalized Medicine. Icahn School of Medicine at Mount Sinai. New York, NY, USA / Novo Nordisk Foundation Center for Basic Metabolic Research. Faculty of Health and Medical Sciences. University of Copenhagen. Copenhagen, Denmark.
The Charles Bronfman Institute of Personalized Medicine. Icahn School of Medicine at Mount Sinai. New York, NY, USA.
Unidad de Investigación Médica en Bioquímica. Hospital de Especialidades. Centro Médico Nacional Siglo XXI. Instituto Mexicano del Seguro Social. Mexico City, Mexico.
Department of Public Health Sciences. School of Medicine. University of California Davis. Davis, CA, USA.
Department of Pediatrics. Genetic and Genomic Medicine. University of California. Irvine, Irvine, CA, USA.
Center for Public Health Genomics, University of Virginia. Charlottesville, VA, USA.
Division of Intramural Research, National Heart, Lung, and Blood Institute. National Institutes of Health. Bethesda, MD, USA.
Departamento de Genética, Ecologia e Evolução. Instituto de Ciências Biológicas. Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
The Institute for Translational Genomics and Population Sciences. Department of Pediatrics. The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center. Torrance, CA USA.
MedStar Health Research Institute. Hyattsville MD and Georgetown-Howard Universities Center for Clinical and Translational Science. Washington, DC, USA.
Department of Genetics. University of North Carolina at Chapel Hill. Chapel Hill, NC, USA.
University of Washington School of Medicine. Seattle, WA, USA / Office of Healthcare Equity. UW Justice, Equity, Diversity, and Inclusion Center for Transformational Research. University of Washington. Seattle, WA, USA / Division of Nephrology. Department of Medicine. University of Washington. Seattle, WA, USA / Kidney Research Institute. Department of Medicine. University of Washington. Seattle, WA, USA.
Cardiovascular Research Center and Center for Genomic Medicine. Massachusetts General Hospital. Boston, MA, USA/Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute, Cambridge, MA, USA.
Center for American Indian Health Research. Department of Biostatistics and Epidemiology. Hudson College of Public Health. The University of Oklahoma Health Sciences Center. Oklahoma, OK, USA.
The Institute for Translational Genomics and Population Sciences. Department of Pediatrics. The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center. Torrance, CA USA
Department of Neurology. Epidemiology and Public Health. Miller School of Medicine. University of Miami. Miami, FL, USA.
The Institute for Translational Genomics and Population Sciences. Department of Pediatrics. The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center. Torrance, CA, USA.
Unidad de Investigación Médica en Bioquímica. Hospital de Especialidades. Centro Médico Nacional Siglo XXI. Instituto Mexicano del Seguro Social. Mexico City, Mexico.
Brown Foundation Institute of Molecular Medicine. Houston, TX, USA.
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.
Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. Instituto do Coração. Laboratório de Genética e Cardiologia Molecular. São Paulo, SP, Brazil / Aging Division, Brigham Women's Hospital, Department of Medicine, Harvard Medical School, Boston, MA, USA.
Population Health Research Institute. Hamilton, ON, Canada / Department of Pathology and Molecular Medicine. McMaster University. Hamilton, ON, Canada.
Cardiovascular Research Center and Center for Genomic Medicine. Massachusetts General Hospital. Boston, MA, USA / Program in Medical and Population Genetics and the Cardiovascular Disease Initiative. Broad Institute. Cambridge, MA, USA / Department of Medicine. Harvard Medical School. Boston, MA, USA.
Texas Biomedical Research Institute. San Antonio, TX, USA.
Department of Medicine. University of Mississippi Medical Center. Jackson, MS, USA.
Department of Biomedical Informatics. University of Colorado Anschutz Medical Campus. Aurora, CO, USA.
Center for Research on Genomics and Global Health. National Human Genome Research Institute. National Institutes of Health. Bethesda, MD, USA.
National Institute on Minority Health and Health Disparities. National Institutes of Health. Bethesda, MD, USA.
The Charles Bronfman Institute of Personalized Medicine. Icahn School of Medicine at Mount Sinai. New York, NY, USA.
School of Science, Psychology and Sport. Federation University. Ballarat, VIC, Australia/Department of Cardiovascular Sciences. University of Leicester.
Division of Cardiovascular Sciences. Faculty of Biology, Medicine, and Health. The University of Manchester. Manchester, UK / Manchester Royal Infirmary. Manchester University NHS Foundation Trust. Manchester Academic Health Science Centre. Manchester, UK.
Department of Public Health Sciences. School of Medicine. University of California Davis. Davis, CA, USA.
Centre for Genetics and Genomics Versus Arthritis. Centre for Musculoskeletal Research. The University of Manchester. Manchester, UK.
Department of Epidemiology. University of North Carolina at Chapel Hill. Chapel Hill, NC, USA.
Abstract
Chronic kidney disease is a leading cause of death and disability globally and impacts individuals of African ancestry (AFR) or with ancestry in the Americas (AMS) who are under-represented in genome-wide association studies (GWASs) of kidney function. To address this bias, we conducted a large meta-analysis of GWASs of estimated glomerular filtration rate (eGFR) in 145,732 AFR and AMS individuals. We identified 41 loci at genome-wide significance (p < 5 × 10-8), of which two have not been previously reported in any ancestry group. We integrated fine-mapped loci with epigenomic and transcriptomic resources to highlight potential effector genes relevant to kidney physiology and disease, and reveal key regulatory elements and pathways involved in renal function and development. We demonstrate the varying but increased predictive power offered by a multi-ancestry polygenic score for eGFR and highlight the importance of population diversity in GWASs and multi-omics resources to enhance opportunities for clinical translation for all.
Keywords
Admixed populationsChronic kidney disease
eGFR
Fine-mapping
Expression quantitative trait locus
Genome-wide association study
Kidney function
Multi-ancestry
Polygenic scores
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