Author | Costa, Bruno Cesar da | |
Author | Dourado, Mauricio Rocha | |
Author | Moraes, Everton Freitas de | |
Author | Panini, Luana Marí | |
Author | Elseragy, Amr | |
Author | Téo, Fábio Haach | |
Author | Guimarães, Gustavo Narvaes | |
Author | Machado, Renato Assis | |
Author | Risteli, Maija | |
Author | Rocha, Clarissa Araujo Gurgel | |
Author | Paranaíba, Lívia Máris Ribeiro | |
Author | Arriagada, Wilfredo Alejandro González | |
Author | Silva, Sabrina Daniela da | |
Author | Rangel, Ana Lucia Carrinho Ayroza | |
Author | Marques, Marcelo Rocha | |
Author | Salo, Tuula | |
Author | Coletta, Ricardo D. | |
Access date | 2024-01-26T18:56:48Z | |
Available date | 2024-01-26T18:56:48Z | |
Document date | 2023 | |
Citation | COSTA, Bruno Cesar da et al. Overexpression of heat-shock protein 47 impacts survival of patients with oral squamous cell carcinoma. Journal of Oral Pathology & Medicine, v. 52, n. 7, p. 1-9, 2023. | en_US |
ISSN | 1600-0714 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/62403 | |
Sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnol ogico (CNPq).
Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG).
Fundaçao de Amparo à Pesquisa do Estado de Sao Paulo (FAPESP).
Universities of Oulu and Helsinki Sigrid Juselius Foundation.
Oulu and Helsinki University Hospital. | en_US |
Language | eng | en_US |
Publisher | Wiley | en_US |
Rights | open access | en_US |
Subject in Portuguese | Invasão | en_US |
Subject in Portuguese | Câncer bucal | en_US |
Subject in Portuguese | Prognóstico | en_US |
Subject in Portuguese | Proliferação | en_US |
Subject in Portuguese | SERPINH1 | en_US |
Title | Overexpression of heat-shock protein 47 impacts survival of patients with oral squamous cell carcinoma | en_US |
Type | Article | en_US |
DOI | 10.1111/jop.13455 | |
Abstract | Background: The expression of heat-shock protein 47 (HSP47) has been linked to collagen synthesis control and implicated in fibrotic disorders, but more recent studies have demonstrated its role in solid tumors. In this study, we explored the prognostic impact of HSP47 in oral squamous cell carcinomas (OSCC) and determined the in vitro effects of its loss-of-function on viability, proliferation, migration, invasion, and resistance to cisplatin of OSCC cells.
Methods: The HSP47 expression in tumor samples was assessed by immunohistochemistry in two independent cohorts totaling 339 patients with OSCC, and protein levels were associated with clinicopathological features and survival outcomes. The OSCC cell lines HSC3 and SCC9 were transduced with lentivirus expressing short hairpin RNA to stably silence HSP47 and used in assays to measure cellular viability, proliferation, migration, and invasion.
Results: HSP47 was overexpressed in OSCC samples, and its overexpression was significantly and independently associated with poor disease-specific survival and shortened disease-free survival in both OSCC cohorts. The knockdown of HSP47 showed no effects on cell viability or cisplatin sensitivity, but impaired significantly proliferation, migration, and invasion of OSCC cells, with stronger effects on SCC9 cells. Conclusion: Our results show a significant prognostic impact of HSP47 overexpression in OSCC and reveal that HSP47 inhibition impairs the proliferation, migration, and invasion of OSCC cells. HSP47 may represent a potential therapeutic target for OSCC. | en_US |
Affilliation | Universidade de Campinas. Faculdade de Odontologia de Piracicaba. Departamento de Diagnóstico Oral e Pós-Graduação. Programa de Biologia Oral. Piracicaba, São Paulo, SP, Brasil. | en_US |
Affilliation | Universidade de Campinas. Faculdade de Odontologia de Piracicaba. Departamento de Diagnóstico Oral e Pós-Graduação. Programa de Biologia Oral. Piracicaba, São Paulo, SP, Brasil. | en_US |
Affilliation | Universidade de Campinas. Faculdade de Odontologia de Piracicaba. Departamento de Diagnóstico Oral e Pós-Graduação. Programa de Biologia Oral. Piracicaba, São Paulo, SP, Brasil. | en_US |
Affilliation | Universidade de Campinas. Faculdade de Odontologia de Piracicaba. Departamento de Diagnóstico Oral e Pós-Graduação. Programa de Biologia Oral. Piracicaba, São Paulo, SP, Brasil. | en_US |
Affilliation | Research Unit of Population Health. University of Oulu. Medical Research Centre and Oulu University Hospital. Oulu, Finland. | en_US |
Affilliation | Universidade de Campinas. Faculdade de Odontologia de Piracicaba. Departamento de Diagnóstico Oral e Pós-Graduação. Programa de Biologia Oral. Piracicaba, São Paulo, SP, Brasil. | en_US |
Affilliation | Universidade Estadual de Campinas. Faculdade de Odontologia de Piracicaba. Departamento de Biociências. Programa de Pós-Graduação em Biologia Oral. Piracicaba, São Paulo, SP, Brasil. | en_US |
Affilliation | Universidade de Campinas. Faculdade de Odontologia de Piracicaba. Departamento de Diagnóstico Oral e Pós-Graduação. Programa de Biologia Oral. Piracicaba, São Paulo, SP, Brasil. | en_US |
Affilliation | Research Unit of Population Health. University of Oulu. Medical Research Centre and Oulu University Hospital. Oulu, Finland. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil / Instituto Dor. Salvador, BA, Brasil. | en_US |
Affilliation | Universidade Federal de Alfenas. Instituto de Ciências Biomédicas. Departamento de Patologia e Parasitologia. Alfenas, MG, Brasil. | en_US |
Affilliation | Facultad de Odontología and Centro de Investigación e Innovación Biomédica (CIIB). Universidad de los Andes. Santiago, Chile. | en_US |
Affilliation | Lady Davis Institute for Medical Research and Segal Cancer Center. Jewish General Hospital. and Department of Otolaryngology-Head and Neck Surgery. McGill University. Montreal, Quebec, Canada. | en_US |
Affilliation | Universidade Estadual do Oeste do Paraná. Escola Dental. Departamento de Patologia Oral e Medicina Oral. Cascavel, PR, Brasil. | en_US |
Affilliation | Universidade Estadual de Campinas. Faculdade de Odontologia de Piracicaba. Departamento de Biociências. Programa de Pós-Graduação em Biologia Oral. Piracicaba, São Paulo, SP, Brasil. | en_US |
Affilliation | Research Unit of Population Health. University of Oulu. Medical Research Centre and Oulu University Hospital. Oulu, Finland / Department of Oral and Maxillofacial Diseases and Department of Pathology. Helsinki University Central Hospital. Translational Immunology Research Program. University of Helsinki. Helsinki, Finland. | en_US |
Affilliation | Universidade de Campinas. Faculdade de Odontologia de Piracicaba. Departamento de Diagnóstico Oral e Pós-Graduação. Programa de Biologia Oral. Piracicaba, São Paulo, SP, Brasil. | en_US |
Subject | Invasion | en_US |
Subject | Oral cancer | en_US |
Subject | Prognosis | en_US |
Subject | Proliferation | en_US |
Subject | SERPINH1 | en_US |
DeCS | Neoplasias bucais | en_US |
DeCS | Prognóstico | en_US |