Author | Silva, Aidê Nunes da | |
Author | Araújo, Thessika Hialla Almeida | |
Author | Boa-Sorte, Ney | |
Author | Farias, Giovanne | |
Author | Barroso, Ana Karina Galvão | |
Author | Carvalho, Antônio de | |
Author | Vicente, Ana Carolina | |
Author | Castro, Bernardo Galvão | |
Author | Grassi, Maria Fernanda Rios | |
Access date | 2024-01-22T15:12:12Z | |
Available date | 2024-01-22T15:12:12Z | |
Document date | 2023 | |
Citation | SILVA, Aidê Nunes da et al. Epidemiological and molecular evidence of intrafamilial transmission through sexual and vertical routes in Bahia, the state with the highest prevalence of HTLV-1 in Brazil. Plos Neglected Tropical Diseases, v. 17, n. 9, p. 1-17, 2023. | en_US |
ISSN | 1935-2735 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/62319 | |
Sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES).
Fundação Nacional para o Desenvolvimento do Ensino Superior Privado (FUNADESP).
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). | en_US |
Language | eng | en_US |
Publisher | Public Library of Science | en_US |
Rights | open access | en_US |
Subject in Portuguese | HTLV-1 | en_US |
Subject in Portuguese | Evidências epidemiológicas e moleculares | en_US |
Subject in Portuguese | Transmissão sexual vertical | en_US |
Subject in Portuguese | Prevalência | en_US |
Subject in Portuguese | Bahia - Brasil | en_US |
Title | Epidemiological and molecular evidence of intrafamilial transmission through sexual and vertical routes in Bahia, the state with the highest prevalence of HTLV-1 in Brazil | en_US |
Type | Article | en_US |
DOI | 10.1371/journal. pntd.0011005 | |
Abstract | Introduction: Familial clustering of HTLV-1 and related diseases has been reported in Brazil. However, intrafamilial transmission of HTLV-1 based on molecular analysis has been studied only in a few communities of Japanese immigrants and African-Brazilians. Objective: To investigate the familial clustering of HTLV-1 infection and to determine the likely routes of transmission through epidemiological and genetic analyzes. Methods: Medical records of 1,759 HTLV-1+ patients from de the Center for HTLV in Salvador, Brazil, were evaluated to identify first-degree relatives previously tested for HTLV-1. Familial clustering was assumed if more than one member of the same family was HTLV-1+. LTR regions of HTLV-1 sequences were analyzed for the presence of intrafamilial polymorphisms. Family pedigrees were constructed and analyzed to infer the likely transmission routes of HTLV-1. Results: In 154 patients at least one other family member had tested positive for HTLV-1 (a total of 182 first-degree relatives). Of the 91 couples (182 individuals), 51.6% were breastfed, and 67.4% reported never using a condom. Of the 42 mother-child pairs, 23.8% had a child aged 13 years or younger; all mothers reported breastfeeding their babies. Pedigrees of families with 4 or more members suggests that vertical transmission is a likely mode of transmission in three families. Three families may have had both vertical and sexual transmission routes for HTLV-1. The genetic signatures of the LTR region of 8 families revealed 3 families with evidence of vertical transmission, another 3 families (spouses) with sexual transmission, and one family with both transmission routes. HTLV-1 sequences belonged to Cosmopolitan subtype HTLV-1a Transcontinental subgroup A. Conclusion: Sexual and vertical transmission routes contribute to the intrafamilial spread of HTLV-1 in the state of Bahia. | en_US |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | en_US |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | en_US |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | en_US |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | en_US |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | en_US |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil. | en_US |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil. | en_US |
Subject | HTLV-1 | en_US |
Subject | Epidemiological and molecular evidence | en_US |
Subject | Transmission sexual vertical | en_US |
Subject | Prevalence | en_US |
Subject | Bahia - Brazil | en_US |
DeCS | HIV-1 | en_US |
DeCS | Infecções Sexualmente Transmissíveis | en_US |
DeCS | Prevalência | en_US |
DeCS | Brasil | en_US |