Author | Almeida-Silva, Fernando | |
Author | Coelho, Rowena A. | |
Author | Bernardes-Engemann, Andrea R. | |
Author | Fichman, Vivian | |
Author | Freitas, Dayvison F. S. | |
Author | Galhardo, Maria C. G. | |
Author | Correa-Junior, Dario | |
Author | Frases, Susana | |
Author | Zancopé-Oliveira, Rosely M. | |
Author | Almeida-Paes, Rodrigo | |
Access date | 2024-01-16T15:36:02Z | |
Available date | 2024-01-16T15:36:02Z | |
Document date | 2023 | |
Citation | ALMEIDA-SILVA, Fernando et al. In vitro isavuconazole activity against Sporothrix brasiliensis suggests its efficacy in some severe sporotrichosis cases. Future Microbiology, v. 18, n. 15, p. 1041–1048, 2023. | en_US |
ISSN | 1746-0913 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/62205 | |
Language | eng | en_US |
Publisher | Future Medicine | en_US |
Rights | restricted access | en_US |
Title | In vitro isavuconazole activity against Sporothrix brasiliensis suggests its efficacy in some severe sporotrichosis cases | en_US |
Type | Article | en_US |
DOI | 10.2217/fmb-2023-0094 | |
Abstract | Background: Sporothrix brasiliensis causes sporotrichosis, an important infection in some groups of patients. Aims: This work was designed to investigate the effects of isavuconazole against this species. Methods: An antifungal susceptibility test was performed to compare MIC values with other antifungal drugs used to treat sporotrichosis. A checkerboard assay was performed to understand isavuconazole interactions. Furthermore, isavuconazole growth inhibition on an itraconazole-resistant strain was tested. Results: Isavuconazole had similar MICs to other azoles against S. brasiliensis, presenting fungistatic activity. Isavuconazole did not interact in vitro with antifungals or immunosuppressive drugs and inhibited the growth of an itraconazole-resistant strain. Conclusion: Isavuconazole inhibits S. brasiliensis, its pharmacologic characteristics make it a candidate for patients with sporotrichosis and it may be useful to combat sporotrichosis caused by resistant isolates. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Universidade do Estado do Rio de Janeiro. Departamento de Dermatologia. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatologia Infecciosa. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatologia Infecciosa. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Biofísica de Fungos. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Biofísica de Fungos. Rio de Janeiro, RJ, Brasil / Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro. Rede Micologia. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil / Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro. Rede Micologia. Rio de Janeiro, RJ, Brasil. | en_US |
Subject | Antifungal | en_US |
Subject | Cell Morphology | en_US |
Subject | Drug Combination | en_US |
Subject | Isavuconazole | en_US |
Subject | Resistance | en_US |
Subject | Sporothrix Brasiliensis | en_US |
Subject | Susceptibility | en_US |
e-ISSN | 1746-0921 | |
Embargo date | 2030-12-31 | |