Author | Silva, Juliana C S | |
Author | Lins, Carlos R B | |
Author | Lacerda, Sarah S | |
Author | Ramos, Rhaíssa E M | |
Author | Araújo, Hallysson D A | |
Author | Melo-Junior, Mario R | |
Author | Alves, Luiz C | |
Author | Brayner, Fábio A | |
Author | Nunes, Iseu S | |
Author | Melo, Fábio L | |
Author | Carvalho, Bruno M | |
Access date | 2023-12-14T12:40:39Z | |
Available date | 2023-12-14T12:40:39Z | |
Document date | 2021 | |
Citation | SILVA, Juliana C.s. et al. In vitro and in vivo effects of P-MAPA immunomodulator on schistosomiasis. Acta Tropica, [S.l.], v. 218, p. 1-8, jun. 2021. | en_US |
ISSN | 1873-6254 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/61760 | |
Language | por | en_US |
Rights | open access | en_US |
MeSH | Animals | en_US |
MeSH | Female | en_US |
MeSH | Granuloma / drug therapy | en_US |
MeSH | Granuloma / pathology | en_US |
MeSH | Humans | en_US |
MeSH | Immunologic Factors / pharmacology | en_US |
MeSH | Intestines / parasitology | en_US |
MeSH | Linoleic Acids / pharmacology* | en_US |
MeSH | Liver / parasitology | en_US |
MeSH | Liver / pathology | en_US |
MeSH | Male | en_US |
MeSH | Mice | en_US |
MeSH | Oleic Acids / pharmacology* | en_US |
MeSH | Organophosphorus Compounds | en_US |
MeSH | Praziquantel / pharmacology* | en_US |
MeSH | Schistosoma mansoni / drug effects* | en_US |
MeSH | Schistosomiasis mansoni / drug therapy* | en_US |
MeSH | Schistosomicides / pharmacology | en_US |
Title | In vitro and in vivo effects of P-MAPA immunomodulator on schistosomiasis | en_US |
Type | Article | en_US |
DOI | 10.1016/j.actatropica.2021.105909 | |
Abstract | Schistosomiasis is an infectious disease caused by helminth parasites of the genus Schistosoma; it is transmitted in over 78 countries. The main strategy for schistosomiasis control is treatment of infected people with praziquantel (PZQ). As PZQ-resistant strains have emerged, new anti-schistosomal agents have become necessary. We evaluated the in vitro and in vivo effect of P-MAPA, an aggregated polymer of protein magnesium ammonium phospholinoleate-palmitoleate anhydride with immunomodulatory properties; it is produced by Aspergillus oryzae fermentation. In vitro, P-MAPA (5, 50, and 100 µg/mL) damaged the Schistosoma mansoni tegument, causing thorn losses and tuber destruction in male worms and peeling and erosion in females after 24-h incubation. In vivo, P-MAPA (5 and 100 mg/kg, alone and combined with PZQ - 50 mg/kg) reduced the number of eggs by up to 69.20% in the liver and 88.08% in the intestine. Furthermore, granulomas were reduced up to 83.13%, and there was an increase in the number of dead eggs and a reduction of serum aspartate aminotransferase levels. These data suggest that P-MAPA activity can help improve schistosomiasis treatment and patients' quality of life. | en_US |
Affilliation | University of Pernambuco. Faculty of Medical Sciences. Recife, PE, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Aggeu Magalhães Institute. Recife, PE, Brazil. | en_US |
Affilliation | Federal University of Pernambuco. Biosciences Centre. Department of Biochemistry. Recife, PE, Brazil. | en_US |
Affilliation | Federal University of Pernambuco. Health Sciences Centre. Recife, PE, Brazil. | en_US |
Affilliation | Farmabrasilis R&D Division. Valinhos, SP, Brazil. | en_US |
Affilliation | University of Pernambuco. Faculty of Medical Sciences. Recife, PE, Brazil. | en_US |
Subject | Antischistosomal agents | en_US |
Subject | Immunomodulators | en_US |
Subject | P-MAPA | en_US |
Subject | Praziquantel | en_US |
Subject | Schistosoma mansoni | en_US |
Subject | Schistosomiasis | en_US |
e-ISSN | 1873-6254 | |