Author | Santos, Ana Amélia Nunes | |
Author | Ribeiro, Priscyla dos Santos | |
Author | França, Geórgia Virgínia da | |
Author | Souza, Fábio Neves | |
Author | Ramos, Eduardo Antônio Gonçalves | |
Author | Figueira, Cláudio Pereira | |
Author | Reis, Mitermayer G. | |
Author | Costa, Federico | |
Author | Ristow, Paula | |
Access date | 2023-11-24T19:29:20Z | |
Available date | 2023-11-24T19:29:20Z | |
Document date | 2023 | |
Citation | SANTOS, Ana Amélia Nunes et al. Leptospira interrogans biofilm formation in Rattus norvegicus (Norway rats) natural reservoirs. PLoS Neglected Tropical Diseases (PLoS NTDs), v. 15, n. 9, p.1-16, 2023. | en_US |
ISSN | 1935-2727 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/61466 | |
Sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
Oswaldo Cruz Fundação (FIOCRUZ).
Universidade Federal da Bahia (UFBA).
Secretaria de Vigilância em Saúde do Estado da Bahia.
National Institutes of Health (NIH).
Wellcome Trust.
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES). | en_US |
Language | eng | en_US |
Publisher | Public Library of Science | en_US |
Rights | open access | en_US |
Subject in Portuguese | Leptospira | en_US |
Subject in Portuguese | Biofilme | en_US |
Subject in Portuguese | Rattus norvegicus | en_US |
Subject in Portuguese | Ratos da Noruega | en_US |
Subject in Portuguese | Reservatórios naturais | en_US |
Title | Leptospira interrogans biofilm formation in Rattus norvegicus (Norway rats) natural reservoirs | en_US |
Type | Article | en_US |
DOI | 10.1371/journal.pntd.0009736 | |
Abstract | Rattus norvegicus (Norway rat) is the main reservoir host of pathogenic Leptospira, the causative agent of leptospirosis, in urban environments. Pathogenic Leptospira forms biofilms in the environment, possibly contributing for bacterial survival and maintenance. Nonetheless, biofilms have not yet been studied in natural animal reservoirs presenting leptospiral renal carriage. Here, we described biofilm formation by pathogenic Leptospira inside the renal tubules of R. norvegicus naturally infected and captured in an urban slum endemic for leptospirosis. From the 65 rats carrying Leptospira in their kidneys, 24 (37%) presented biofilms inside the renal tubules. The intensity of leptospiral colonization in the renal tubules (OR: 1.00; 95% CI 1.05–1.1) and the type of occlusion pattern of the colonized renal tubules (OR: 3.46; 95% CI 1.20–9.98) were independently associated with the presence of Leptospira biofilm. Our data showed that Leptospira interrogans produce biofilms during renal chronic colonization in rat reservoirs, suggesting a possible role for leptospiral biofilms in the pathogenesis of leptospirosis and bacterial carriage in host reservoirs. | en_US |
Affilliation | Universidade Federal da Bahia. Instituto de Biologia. Salvador, BA, Brasil. | en_US |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brasil. | en_US |
Affilliation | Universidade Federal da Bahia. Instituto de Biologia. Salvador, BA, Brasil. | en_US |
Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil. | en_US |
Affilliation | Ministério da Saúde. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Ministério da Saúde. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Ministério da Saúde. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil / Department of Epidemiology of Microbial Diseases. School of Public Health. Yale University. New Haven, Connecticut, United States of America. | en_US |
Affilliation | Universidade Federal da Bahia. Instituto de Biologia. Salvador, BA, Brasil. | en_US |
Subject | Leptospira | en_US |
Subject | Biofilm | en_US |
Subject | Rattus norvegicus | en_US |
Subject | Norway rats | en_US |
Subject | Natural reservoirs | en_US |
DeCS | Leptospira | en_US |
DeCS | Biofilmes | en_US |
DeCS | Ratos | en_US |