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3100-12-31
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COVID-19 AND CANDIDURIA: AN INVESTIGATION OF THE RISK FACTORS AND IMMUNOLOGICAL ASPECTS.
Author
Singulani, Junya de Lacorte
Silva, Danielle Letícia da
Lima, Caroline M.
Magalhães, Vanessa C. R.
Baltazar, Ludmila de Matos
Santos, Ana Raquel O.
Johann, Susana
Peres, Nalu Teixeira de Aguiar
Reis, Jordana Grazziela Alves Coelho dos
Santos, Daniel A.
Magalhães, Vanessa C. R.
Moura, Alexandre S.
Fereguetti, Tatiani
Martins, Juliana C.
Rabelo, Lívia F.
Lyon, Ana C.
Moura, Alexandre S.
Martins Filho, Olindo Assis
Silva, Danielle Letícia da
Lima, Caroline M.
Magalhães, Vanessa C. R.
Baltazar, Ludmila de Matos
Santos, Ana Raquel O.
Johann, Susana
Peres, Nalu Teixeira de Aguiar
Reis, Jordana Grazziela Alves Coelho dos
Santos, Daniel A.
Magalhães, Vanessa C. R.
Moura, Alexandre S.
Fereguetti, Tatiani
Martins, Juliana C.
Rabelo, Lívia F.
Lyon, Ana C.
Moura, Alexandre S.
Martins Filho, Olindo Assis
Affilliation
Department of Microbiology. Institute of Biological Sciences. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil
Department of Microbiology. Institute of Biological Sciences. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil
Department of Microbiology. Institute of Biological Sciences. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil
Department of Microbiology. Institute of Biological Sciences. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil
Department of Microbiology. Institute of Biological Sciences. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil
Department of Microbiology. Institute of Biological Sciences. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil
Department of Microbiology. Institute of Biological Sciences. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil
Department of Microbiology. Institute of Biological Sciences. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil
Department of Microbiology. Institute of Biological Sciences. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil
Department of Microbiology. Institute of Biological Sciences. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil
Estado de Minas Gerais. Fundação Hospitalar. Hospital Eduardo de Menezes. Belo Horizonte, MG, Brazil
Estado de Minas Gerais. Fundação Hospitalar. Hospital Eduardo de Menezes. Belo Horizonte, MG, Brazil
Estado de Minas Gerais. Fundação Hospitalar. Hospital Eduardo de Menezes. Belo Horizonte, MG, Brazil
Estado de Minas Gerais. Fundação Hospitalar. Hospital Eduardo de Menezes. Belo Horizonte, MG, Brazil
Estado de Minas Gerais. Fundação Hospitalar. Hospital Eduardo de Menezes. Belo Horizonte, MG, Brazil
Estado de Minas Gerais. Fundação Hospitalar. Hospital Eduardo de Menezes. Belo Horizonte, MG, Brazil
Center of Post-Graduation and Research. Faculdade Santa Casa de Belo Horizonte. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brazil
Department of Microbiology. Institute of Biological Sciences. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil
Department of Microbiology. Institute of Biological Sciences. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil
Department of Microbiology. Institute of Biological Sciences. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil
Department of Microbiology. Institute of Biological Sciences. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil
Department of Microbiology. Institute of Biological Sciences. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil
Department of Microbiology. Institute of Biological Sciences. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil
Department of Microbiology. Institute of Biological Sciences. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil
Department of Microbiology. Institute of Biological Sciences. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil
Department of Microbiology. Institute of Biological Sciences. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil
Estado de Minas Gerais. Fundação Hospitalar. Hospital Eduardo de Menezes. Belo Horizonte, MG, Brazil
Estado de Minas Gerais. Fundação Hospitalar. Hospital Eduardo de Menezes. Belo Horizonte, MG, Brazil
Estado de Minas Gerais. Fundação Hospitalar. Hospital Eduardo de Menezes. Belo Horizonte, MG, Brazil
Estado de Minas Gerais. Fundação Hospitalar. Hospital Eduardo de Menezes. Belo Horizonte, MG, Brazil
Estado de Minas Gerais. Fundação Hospitalar. Hospital Eduardo de Menezes. Belo Horizonte, MG, Brazil
Estado de Minas Gerais. Fundação Hospitalar. Hospital Eduardo de Menezes. Belo Horizonte, MG, Brazil
Center of Post-Graduation and Research. Faculdade Santa Casa de Belo Horizonte. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brazil
Abstract
Secondary fungal infections are frequently observed in COVID-19 patients. However, the occurrence of candiduria in these patients and its risk factors are underexplored. We evaluated the risk factors of candiduria in COVID-19 patients, including inflammatory mediators that could be used as prognostic markers. Clinical information, laboratory test results, and outcomes were collected from severely ill COVID-19 patients with and without candiduria. Candida species identification, antifungal susceptibility, and plasma inflammatory mediators’ measurements were performed. Regression logistic and Cox regression model were used to evaluate the risk factors. A higher risk of longer hospitalization and mortality were observed in patients with candiduria compared to those with COVID-19 only. Candiduria was caused by Candida albicans, C. glabrata, and C. tropicalis. Isolates with intermediate susceptibility to voriconazole and resistant to caspofungin were identified. Classic factors such as the use of corticosteroids and antibacterials, the worsening of renal function, and hematological parameters (hemoglobin and platelets) were found to predispose to candiduria. The mediators IL-1β, IL-1ra, IL-2, CXCL-8, IL-17, IFN-γ, basic FGF, and MIP-1β were significantly increased in patients with COVID-19 and candiduria. Furthermore, IFN-γ, IL-1ra, and CXCL-8 were associated with the occurrence of candiduria in COVID-19 patients, whereas basic FGF, IL-1β, and CXCL-8 were associated with the risk of death in these patients. Classical and immunological factors were associated with worse prognosis among patients with COVID-19 and candiduria. Some mediators, especially CXCL-8, can be a reliable biomarker of fungal coinfection and may guide the diagnostic and the treatment of these patients.
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