Author | Coelho, Rowena Alves | |
Author | Figueiredo-Carvalho, Maria Helena Galdino | |
Author | Almeida-Silva, Fernando | |
Author | Rabello, Vanessa Brito de Souza | |
Author | Souza, Gabriela Rodrigues de | |
Author | Sangenito, Leandro Stefano | |
Author | Joffe, Luna Sobrino | |
Author | Santos, André Luis Souza dos | |
Author | Lourenço, Maria Cristina da Silva | |
Author | Rodrigues, Marcio L. | |
Author | Almeida-Paes, Rodrigo | |
Access date | 2023-10-25T17:45:45Z | |
Available date | 2023-10-25T17:45:45Z | |
Document date | 2023 | |
Citation | COELHO, Rowena Alves et al. Repurposing Benzimidazoles against Causative Agents of Chromoblastomycosis: Albendazole Has Superior In Vitro Activity Than Mebendazole and Thiabendazole. Journal of fungi, v. 9, n. 7, p. 1-15, Jul. 2023. | en_US |
ISSN | 2309-608X | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/60924 | |
Sponsorship | This research was funded by Programa Inova Fiocruz, grant number VPPCB-008-FIO-18-2-49 and Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro, grant number 201.441/2021. | en_US |
Language | eng | en_US |
Publisher | MDPI | en_US |
Rights | open access | en_US |
Title | Repurposing Benzimidazoles against Causative Agents of Chromoblastomycosis: Albendazole Has Superior In Vitro Activity Than Mebendazole and Thiabendazole | en_US |
Type | Article | en_US |
DOI | 10.3390/jof9070753 | |
Abstract | Chromoblastomycosis (CBM) is a neglected human implantation mycosis caused by several dematiaceous fungal species. Currently available therapy is usually associated with physical methods, especially surgery, and with high refractoriness. Therefore, drug discovery for CBM is essential. Drug repositioning is a strategy used to facilitate the discovery of new treatments for several diseases. The aim of this study was to discover substances with antifungal activity against CBM agents from a collection of drugs previously approved for use in human diseases. A screening was performed with the NIH Clinical Collection against Fonsecaea pedrosoi. Ten substances, with clinical applicability in CBM, inhibited fungal growth by at least 60%. The minimum inhibitory concentration (MIC) of these substances was determined against other CBM agents, and the benzimidazoles albendazole, mebendazole and thiabendazole presented the lowest MIC values. The selectivity index, based on MIC and cytotoxicity of these substances, revealed albendazole to be more selective. To investigate a possible synergism of this benzimidazole with itraconazole and terbinafine, the chequerboard method was used. All interactions were classified as indifferent. Our current results suggest that benzimidazoles have repositioning potential against CBM agents. Albendazole seems to be the most promising, since it presented the highest selectivity against all dematiaceous fungi tested. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Plataforma de Bioensaios RPT 11B. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Goés. Laboratório de Estudos Avançados de Microrganismos Emergentes e Resistentes. Departamento de Microbiologia Geral. Rio de Janeiro, RJ, Brasil / Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro. Nilópolis, RJ, Brasil. | en_US |
Affilliation | Stony Brook University. Department of Microbiology and Immunology. Stony Brook, NY, USA. | |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Goés. Laboratório de Estudos Avançados de Microrganismos Emergentes e Resistentes. Departamento de Microbiologia Geral. Rio de Janeiro, RJ, Brasil / Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro. Rede Micologia RJ, Rio de Janeiro, RJ, Brasil. | |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Plataforma de Bioensaios RPT 11B. Rio de Janeiro, RJ, Brasil. | |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Rio de Janeiro, RJ, Brasil. | |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Rio de Janeiro, RJ, Brasil. | |
Subject | Fonsecaea pedrosoi | en_US |
Subject | Albendazole | en_US |
Subject | Benzimidazoles | en_US |
Subject | Chromoblastomycosis | en_US |
Subject | Drug repositioning | en_US |
e-ISSN | 2309-608X | |