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https://www.arca.fiocruz.br/handle/icict/60727
EXPLORING THE NEANDERTAL LEGACY OF PANCREATIC DUCTAL ADENOCARCINOMA RISK IN EURASIANS
Polimorfismo de Nucleótido Simple
Carcinoma Ductal Pancreático
Author
Piccardi, Margherita
Gentiluomo, Manuel
Bertoncini, Stefania
Pezzilli, Raffaele
Erőss, Bálint
Bunduc, Stefania
Uzunoglu, Faik G.
Talar‑Wojnarowska, Renata
Vanagas, Tomas
Sperti, Cosimo
Oliverius, Martin
Aoki, Mateus Nóbrega
Ermini, Stefano
Hussein, Tamás
Boggi, Ugo
Jamroziak, Krzysztof
Maiello, Evaristo
Morelli, Luca
Vodickova, Ludmila
Di Franco, Gregorio
Landi, Stefano
Szentesi, Andrea
Lovecek, Martin
Puzzono, Marta
Tavano, Francesca
Laarhoven, Hanneke W. M. van
Zerbi, Alessandro
Mohelnikova‑Duchonova, Beatrice
Stocker, Hannah
Costello, Eithne
Capurso, Gabriele
Ginocchi, Laura
Lawlor, Rita T.
Vanella, Giuseppe
Bazzocchi, Francesca
Izbicki, Jakob R.
Latiano, Anna
Bueno‑de‑Mesquita, Bas
Pisani, Ruggero Ponz de Leon
Schöttker, Ben
Soucek, Pavel
Hegyi, Péter
Gazouli, Maria
Hackert, Thilo
Kupcinskas, Juozas
Poskiene, Lina
Tacelli, Matteo
Roth, Susanne
Carrara, Silvia
Perri, Francesco
Hlavac, Viktor
Theodoropoulos, George E.
Busch, Olivier R.
Mambrini, Andrea
Eijck, Casper H. J. van
Arcidiacono, Paolo
Scarpa, Aldo
Pasquali, Claudio
Basso, Daniela
Lucchesi, Maurizio
Milanetto, Anna Caterina
Neoptolemos, John P.
Cavestro, Giulia Martina
Janciauskas, Dainius
Chen, Xuechen
Chammas, Roger
Goetz, Mara
Brenner, Hermann
Archibugi, Livia
Dannemann, Michael
Canzian, Federico
Tofanelli, Sergio
Campa, Daniele
Gentiluomo, Manuel
Bertoncini, Stefania
Pezzilli, Raffaele
Erőss, Bálint
Bunduc, Stefania
Uzunoglu, Faik G.
Talar‑Wojnarowska, Renata
Vanagas, Tomas
Sperti, Cosimo
Oliverius, Martin
Aoki, Mateus Nóbrega
Ermini, Stefano
Hussein, Tamás
Boggi, Ugo
Jamroziak, Krzysztof
Maiello, Evaristo
Morelli, Luca
Vodickova, Ludmila
Di Franco, Gregorio
Landi, Stefano
Szentesi, Andrea
Lovecek, Martin
Puzzono, Marta
Tavano, Francesca
Laarhoven, Hanneke W. M. van
Zerbi, Alessandro
Mohelnikova‑Duchonova, Beatrice
Stocker, Hannah
Costello, Eithne
Capurso, Gabriele
Ginocchi, Laura
Lawlor, Rita T.
Vanella, Giuseppe
Bazzocchi, Francesca
Izbicki, Jakob R.
Latiano, Anna
Bueno‑de‑Mesquita, Bas
Pisani, Ruggero Ponz de Leon
Schöttker, Ben
Soucek, Pavel
Hegyi, Péter
Gazouli, Maria
Hackert, Thilo
Kupcinskas, Juozas
Poskiene, Lina
Tacelli, Matteo
Roth, Susanne
Carrara, Silvia
Perri, Francesco
Hlavac, Viktor
Theodoropoulos, George E.
Busch, Olivier R.
Mambrini, Andrea
Eijck, Casper H. J. van
Arcidiacono, Paolo
Scarpa, Aldo
Pasquali, Claudio
Basso, Daniela
Lucchesi, Maurizio
Milanetto, Anna Caterina
Neoptolemos, John P.
Cavestro, Giulia Martina
Janciauskas, Dainius
Chen, Xuechen
Chammas, Roger
Goetz, Mara
Brenner, Hermann
Archibugi, Livia
Dannemann, Michael
Canzian, Federico
Tofanelli, Sergio
Campa, Daniele
Affilliation
Department of Biology. Unit of Genetics. University of Pisa. Pisa, Italy.
Department of Biology. Unit of Genetics. University of Pisa. Pisa, Italy.
Department of Biology. Unit of Zoology and Anthropology. University of Pisa. Pisa, Italy.
Potenza County Medical Association. Potenza, Italy.
Institute for Translational Medicine. Medical School. University of Pécs. Pécs, Hungary.
Institute for Translational Medicine. Medical School. University of Pécs. Pécs, Hungary. / Centre for Translational Medicine. Semmelweis University. Budapest, Hungary. / Division of Pancreatic Diseases. Heart and Vascular Center. Semmelweis University. Budapest, Hungary. / Carol Davila University of Medicine and Pharmacy. Bucharest, Romania.
Department of General. Visceral and Thoracic Surgery. University Medical Center Hamburg-Eppendorf. Hamburg, Germany.
Department of Digestive Tract Diseases. Medical University of Lodz. Lodz, Poland.
Department of Surgery. Lithuanian University of Health Sciences. Kaunas, Lithuania.
Department DISCOG. Chirurgia Generale 1. University of Padova. Padua, Italy.
Department of Surgery. Third Faculty of Medicine. University Hospital Kralovske Vinohrady. Charles University. Prague, Czech Republic.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil.
Blood Transfusion Service. Azienda Ospedaliero-Universitaria Meyer. Children’s Hospital. Florence, Italy.
Institute for Translational Medicine. Medical School. University of Pécs. Pécs, Hungary.
Division of General and Transplantation Surgery. University of Pisa. Pisa, Italy.
Department of Hematology. Transplantation and Internal Medicine. Medical University of Warsaw. Warsaw, Poland.
Department of Oncology. Fondazione IRCCS “Casa Sollievo della Sofferenza” Hospital. San Giovanni Rotondo. Foggia, Italy.
Department of Translational Research and New Technologies in Medicine and Surgery. General Surgery Unit. University of Pisa. Pisa, Italy.
Department of Molecular Biology of Cancer. Institute of Experimental Medicine of the Czech Academy of Sciences. Prague, Czechia. / Biomedical Center. Faculty of Medicine in Pilsen. Charles University. Pilsen, Czechia. / Institute of Biology and Medical Genetics. First Faculty of Medicine. Charles University. Prague, Czech Republic.
Department of Translational Research and New Technologies in Medicine and Surgery. General Surgery Unit. University of Pisa. Pisa, Italy.
Department of Biology. Unit of Genetics. University of Pisa. Pisa, Italy.
Institute for Translational Medicine. Medical School. University of Pécs. Pécs, Hungary. / János Szentágothai Research Center. University of Pécs. Pécs, Hungary. / Centre for Translational Medicine. Semmelweis University. Budapest, Hungary.
Department of Surgery I. University Hospital Olomouc. Olomouc, Czech Republic.
Gastroenterology and Gastrointestinal Endoscopy Unit. Vita-Salute San Raffaele University. IRCCS San Raffaele Scientific Institute. Milan, Italy.
Division of Gastroenterology and Research Laboratory. Fondazione IRCCS “Casa Sollievo della Sofferenza” Hospital. San Giovanni Rotondo, Italy.
Department of Medical Oncology. Amsterdam UMC. Cancer Center Amsterdam. University of Amsterdam. Amsterdam, The Netherlands.
Pancreatic Unit. IRCCS Humanitas Research Hospital. Milan, Italy. / Department of Biomedical Sciences. Humanitas University. Milan, Italy.
Department of Oncology. Faculty of Medicine and Dentistry. Palacky University. Olomouc, Czech Republic.
Division of Clinical Epidemiology and Aging Research. German Cancer Research Center. Heidelberg, Germany. / Network Aging Research. Heidelberg University. Heidelberg, Germany.
Department of Molecular & Clinical Cancer Medicine. University of Liverpool. Liverpool, UK.
Digestive and Liver Disease Unit. Sant’Andrea Hospital. Rome, Italy. / Pancreas Translational and Clinical Research Center. Pancreato‑Biliary Endoscopy and Endoscopic Ultrasound. San Raffaele Scientific Institute IRCCS. Milan, Italy.
Oncological Department. Oncology of Massa Carrara. ASL Toscana Nord Ovest. Massa Carrara, Italy.
ARC‑NET Research Centre and Department of Diagnostics and Public Health. Section of Pathology. University of Verona. Verona, Italy.
Digestive and Liver Disease Unit. Sant’Andrea Hospital. Rome, Italy. / Pancreas Translational and Clinical Research Center. Pancreato‑Biliary Endoscopy and Endoscopic Ultrasound. San Raffaele Scientific Institute IRCCS. Milan, Italy.
Department of Oncology. Fondazione IRCCS “Casa Sollievo della Sofferenza” Hospital. San Giovanni Rotondo. Foggia, Italy.
Department of General. Visceral and Thoracic Surgery. University Medical Center Hamburg-Eppendorf. Hamburg, Germany.
Division of Gastroenterology and Research Laboratory. Fondazione IRCCS “Casa Sollievo della Sofferenza” Hospital. San Giovanni Rotondo, Italy.
Centre for Nutrition. Prevention and Health Services. National Institute for Public Health and the Environment. Bilthoven, The Netherlands.
Pancreato‑Biliary Endoscopy and Endoscopic Ultrasound. Pancreas Translational and Clinical Research Center. San Raffaele Scientific Institute IRCCS. Milan, Italy.
Division of Clinical Epidemiology and Aging Research. German Cancer Research Center. Heidelberg, Germany. / Network Aging Research. Heidelberg University. Heidelberg, Germany.
Biomedical Center. Faculty of Medicine in Pilsen. Charles University. Pilsen, Czechia.
Institute for Translational Medicine. Medical School. University of Pécs. Pécs, Hungary. / János Szentágothai Research Center. University of Pécs. Pécs, Hungary. / Centre for Translational Medicine. Semmelweis University. Budapest, Hungary. / Division of Pancreatic Diseases. Heart and Vascular Center. Semmelweis University. Budapest, Hungary.
Laboratory of Biology. Medical School. National and Kapodistrian University of Athens. Athens, Greece.
Department of General, Visceral, and Transplantation Surgery. University of Heidelberg. Heidelberg, Germany.
Department of Gastroenterology and Institute for Digestive Research. Lithuanian University of Health Sciences. Kaunas, Lithuania.
Department of Pathology. Lithuanian University of Health Sciences. Kaunas, Lithuania.
Pancreato‑Biliary Endoscopy and Endoscopic Ultrasound. Pancreas Translational and Clinical Research Center. San Raffaele Scientific Institute IRCCS. Milan, Italy.
Department of General, Visceral, and Transplantation Surgery. University of Heidelberg. Heidelberg, Germany.
Department of Gastroenterology. Endoscopic Unit. IRCCS Humanitas Research Hospital. Milan, Italy.
Division of Gastroenterology and Research Laboratory. Fondazione IRCCS “Casa Sollievo della Sofferenza” Hospital. San Giovanni Rotondo, Italy.
Biomedical Center. Faculty of Medicine in Pilsen. Charles University. Pilsen, Czechia.
First Department of Propaedeutic Surgery. Hippocration General Hospital. National and Kapodistrian University of Athens. Athens, Greece.
Department of Surgery. Amsterdam UMC. Cancer Center Amsterdam. University of Amsterdam. Amsterdam, the Netherlands.
Oncological Department. Oncology of Massa Carrara. ASL Toscana Nord Ovest. Massa Carrara, Italy.
Department of Surgery. Erasmus MC University Medical Center. Rotterdam, the Netherlands.
Pancreato‑Biliary Endoscopy and Endoscopic Ultrasound. Pancreas Translational and Clinical Research Center. San Raffaele Scientific Institute IRCCS. Milan, Italy.
ARC‑NET Research Centre and Department of Diagnostics and Public Health. Section of Pathology. University of Verona. Verona, Italy.
Department DISCOG. Chirurgia Generale 3. University of Padova. Padua, Italy.
Department DIMED. Laboratory Medicine. University of Padova. Padua, Italy.
Oncological Department. Oncology of Massa Carrara. ASL Toscana Nord Ovest. Massa Carrara, Italy.
Department DISCOG. Chirurgia Generale 3. University of Padova. Padua, Italy.
Department of General, Visceral, and Transplantation Surgery. University of Heidelberg. Heidelberg, Germany.
Gastroenterology and Gastrointestinal Endoscopy Unit. Vita-Salute San Raffaele University. IRCCS San Raffaele Scientific Institute. Milan, Italy.
Department of Pathology. Lithuanian University of Health Sciences. Kaunas, Lithuania.
Division of Clinical Epidemiology and Aging Research. German Cancer Research Center. Heidelberg, Germany. / Medical Faculty Heidelberg. University of Heidelberg. Heidelberg, Germany.
Universidade de São Paulo. Faculdade de Medicina. São Paulo, SP, Brasil. / Division of Preventive Oncology. German Cancer Research Center and National Center for Tumor Diseases. Heidelberg, Germany.
Department of General. Visceral and Thoracic Surgery. University Medical Center Hamburg-Eppendorf. Hamburg, Germany.
Division of Clinical Epidemiology and Aging Research. German Cancer Research Center. Heidelberg, Germany. / Division of Preventive Oncology. German Cancer Research Center and National Center for Tumor Diseases. Heidelberg, Germany. / German Cancer Consortium. German Cancer Research Center. Heidelberg, Germany.
Digestive and Liver Disease Unit. Sant’Andrea Hospital. Rome, Italy. / Pancreas Translational and Clinical Research Center. Pancreato‑Biliary Endoscopy and Endoscopic Ultrasound. San Raffaele Scientific Institute IRCCS. Milan, Italy.
Estonian Biocentre. Institute of Genomics. University of Tartu. Tartu, Estonia.
Genomic Epidemiology Group. German Cancer Research Center. Heidelberg, Germany.
Department of Biology. Unit of Zoology and Anthropology. University of Pisa. Pisa, Italy.
Department of Biology. Unit of Genetics. University of Pisa. Pisa, Italy.
Department of Biology. Unit of Genetics. University of Pisa. Pisa, Italy.
Department of Biology. Unit of Zoology and Anthropology. University of Pisa. Pisa, Italy.
Potenza County Medical Association. Potenza, Italy.
Institute for Translational Medicine. Medical School. University of Pécs. Pécs, Hungary.
Institute for Translational Medicine. Medical School. University of Pécs. Pécs, Hungary. / Centre for Translational Medicine. Semmelweis University. Budapest, Hungary. / Division of Pancreatic Diseases. Heart and Vascular Center. Semmelweis University. Budapest, Hungary. / Carol Davila University of Medicine and Pharmacy. Bucharest, Romania.
Department of General. Visceral and Thoracic Surgery. University Medical Center Hamburg-Eppendorf. Hamburg, Germany.
Department of Digestive Tract Diseases. Medical University of Lodz. Lodz, Poland.
Department of Surgery. Lithuanian University of Health Sciences. Kaunas, Lithuania.
Department DISCOG. Chirurgia Generale 1. University of Padova. Padua, Italy.
Department of Surgery. Third Faculty of Medicine. University Hospital Kralovske Vinohrady. Charles University. Prague, Czech Republic.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil.
Blood Transfusion Service. Azienda Ospedaliero-Universitaria Meyer. Children’s Hospital. Florence, Italy.
Institute for Translational Medicine. Medical School. University of Pécs. Pécs, Hungary.
Division of General and Transplantation Surgery. University of Pisa. Pisa, Italy.
Department of Hematology. Transplantation and Internal Medicine. Medical University of Warsaw. Warsaw, Poland.
Department of Oncology. Fondazione IRCCS “Casa Sollievo della Sofferenza” Hospital. San Giovanni Rotondo. Foggia, Italy.
Department of Translational Research and New Technologies in Medicine and Surgery. General Surgery Unit. University of Pisa. Pisa, Italy.
Department of Molecular Biology of Cancer. Institute of Experimental Medicine of the Czech Academy of Sciences. Prague, Czechia. / Biomedical Center. Faculty of Medicine in Pilsen. Charles University. Pilsen, Czechia. / Institute of Biology and Medical Genetics. First Faculty of Medicine. Charles University. Prague, Czech Republic.
Department of Translational Research and New Technologies in Medicine and Surgery. General Surgery Unit. University of Pisa. Pisa, Italy.
Department of Biology. Unit of Genetics. University of Pisa. Pisa, Italy.
Institute for Translational Medicine. Medical School. University of Pécs. Pécs, Hungary. / János Szentágothai Research Center. University of Pécs. Pécs, Hungary. / Centre for Translational Medicine. Semmelweis University. Budapest, Hungary.
Department of Surgery I. University Hospital Olomouc. Olomouc, Czech Republic.
Gastroenterology and Gastrointestinal Endoscopy Unit. Vita-Salute San Raffaele University. IRCCS San Raffaele Scientific Institute. Milan, Italy.
Division of Gastroenterology and Research Laboratory. Fondazione IRCCS “Casa Sollievo della Sofferenza” Hospital. San Giovanni Rotondo, Italy.
Department of Medical Oncology. Amsterdam UMC. Cancer Center Amsterdam. University of Amsterdam. Amsterdam, The Netherlands.
Pancreatic Unit. IRCCS Humanitas Research Hospital. Milan, Italy. / Department of Biomedical Sciences. Humanitas University. Milan, Italy.
Department of Oncology. Faculty of Medicine and Dentistry. Palacky University. Olomouc, Czech Republic.
Division of Clinical Epidemiology and Aging Research. German Cancer Research Center. Heidelberg, Germany. / Network Aging Research. Heidelberg University. Heidelberg, Germany.
Department of Molecular & Clinical Cancer Medicine. University of Liverpool. Liverpool, UK.
Digestive and Liver Disease Unit. Sant’Andrea Hospital. Rome, Italy. / Pancreas Translational and Clinical Research Center. Pancreato‑Biliary Endoscopy and Endoscopic Ultrasound. San Raffaele Scientific Institute IRCCS. Milan, Italy.
Oncological Department. Oncology of Massa Carrara. ASL Toscana Nord Ovest. Massa Carrara, Italy.
ARC‑NET Research Centre and Department of Diagnostics and Public Health. Section of Pathology. University of Verona. Verona, Italy.
Digestive and Liver Disease Unit. Sant’Andrea Hospital. Rome, Italy. / Pancreas Translational and Clinical Research Center. Pancreato‑Biliary Endoscopy and Endoscopic Ultrasound. San Raffaele Scientific Institute IRCCS. Milan, Italy.
Department of Oncology. Fondazione IRCCS “Casa Sollievo della Sofferenza” Hospital. San Giovanni Rotondo. Foggia, Italy.
Department of General. Visceral and Thoracic Surgery. University Medical Center Hamburg-Eppendorf. Hamburg, Germany.
Division of Gastroenterology and Research Laboratory. Fondazione IRCCS “Casa Sollievo della Sofferenza” Hospital. San Giovanni Rotondo, Italy.
Centre for Nutrition. Prevention and Health Services. National Institute for Public Health and the Environment. Bilthoven, The Netherlands.
Pancreato‑Biliary Endoscopy and Endoscopic Ultrasound. Pancreas Translational and Clinical Research Center. San Raffaele Scientific Institute IRCCS. Milan, Italy.
Division of Clinical Epidemiology and Aging Research. German Cancer Research Center. Heidelberg, Germany. / Network Aging Research. Heidelberg University. Heidelberg, Germany.
Biomedical Center. Faculty of Medicine in Pilsen. Charles University. Pilsen, Czechia.
Institute for Translational Medicine. Medical School. University of Pécs. Pécs, Hungary. / János Szentágothai Research Center. University of Pécs. Pécs, Hungary. / Centre for Translational Medicine. Semmelweis University. Budapest, Hungary. / Division of Pancreatic Diseases. Heart and Vascular Center. Semmelweis University. Budapest, Hungary.
Laboratory of Biology. Medical School. National and Kapodistrian University of Athens. Athens, Greece.
Department of General, Visceral, and Transplantation Surgery. University of Heidelberg. Heidelberg, Germany.
Department of Gastroenterology and Institute for Digestive Research. Lithuanian University of Health Sciences. Kaunas, Lithuania.
Department of Pathology. Lithuanian University of Health Sciences. Kaunas, Lithuania.
Pancreato‑Biliary Endoscopy and Endoscopic Ultrasound. Pancreas Translational and Clinical Research Center. San Raffaele Scientific Institute IRCCS. Milan, Italy.
Department of General, Visceral, and Transplantation Surgery. University of Heidelberg. Heidelberg, Germany.
Department of Gastroenterology. Endoscopic Unit. IRCCS Humanitas Research Hospital. Milan, Italy.
Division of Gastroenterology and Research Laboratory. Fondazione IRCCS “Casa Sollievo della Sofferenza” Hospital. San Giovanni Rotondo, Italy.
Biomedical Center. Faculty of Medicine in Pilsen. Charles University. Pilsen, Czechia.
First Department of Propaedeutic Surgery. Hippocration General Hospital. National and Kapodistrian University of Athens. Athens, Greece.
Department of Surgery. Amsterdam UMC. Cancer Center Amsterdam. University of Amsterdam. Amsterdam, the Netherlands.
Oncological Department. Oncology of Massa Carrara. ASL Toscana Nord Ovest. Massa Carrara, Italy.
Department of Surgery. Erasmus MC University Medical Center. Rotterdam, the Netherlands.
Pancreato‑Biliary Endoscopy and Endoscopic Ultrasound. Pancreas Translational and Clinical Research Center. San Raffaele Scientific Institute IRCCS. Milan, Italy.
ARC‑NET Research Centre and Department of Diagnostics and Public Health. Section of Pathology. University of Verona. Verona, Italy.
Department DISCOG. Chirurgia Generale 3. University of Padova. Padua, Italy.
Department DIMED. Laboratory Medicine. University of Padova. Padua, Italy.
Oncological Department. Oncology of Massa Carrara. ASL Toscana Nord Ovest. Massa Carrara, Italy.
Department DISCOG. Chirurgia Generale 3. University of Padova. Padua, Italy.
Department of General, Visceral, and Transplantation Surgery. University of Heidelberg. Heidelberg, Germany.
Gastroenterology and Gastrointestinal Endoscopy Unit. Vita-Salute San Raffaele University. IRCCS San Raffaele Scientific Institute. Milan, Italy.
Department of Pathology. Lithuanian University of Health Sciences. Kaunas, Lithuania.
Division of Clinical Epidemiology and Aging Research. German Cancer Research Center. Heidelberg, Germany. / Medical Faculty Heidelberg. University of Heidelberg. Heidelberg, Germany.
Universidade de São Paulo. Faculdade de Medicina. São Paulo, SP, Brasil. / Division of Preventive Oncology. German Cancer Research Center and National Center for Tumor Diseases. Heidelberg, Germany.
Department of General. Visceral and Thoracic Surgery. University Medical Center Hamburg-Eppendorf. Hamburg, Germany.
Division of Clinical Epidemiology and Aging Research. German Cancer Research Center. Heidelberg, Germany. / Division of Preventive Oncology. German Cancer Research Center and National Center for Tumor Diseases. Heidelberg, Germany. / German Cancer Consortium. German Cancer Research Center. Heidelberg, Germany.
Digestive and Liver Disease Unit. Sant’Andrea Hospital. Rome, Italy. / Pancreas Translational and Clinical Research Center. Pancreato‑Biliary Endoscopy and Endoscopic Ultrasound. San Raffaele Scientific Institute IRCCS. Milan, Italy.
Estonian Biocentre. Institute of Genomics. University of Tartu. Tartu, Estonia.
Genomic Epidemiology Group. German Cancer Research Center. Heidelberg, Germany.
Department of Biology. Unit of Zoology and Anthropology. University of Pisa. Pisa, Italy.
Department of Biology. Unit of Genetics. University of Pisa. Pisa, Italy.
Abstract
The genomes of present-day non-Africans are composed of 1–3% of Neandertal-derived DNA as a consequence of admixture events between Neandertals and anatomically modern humans about 50–60 thousand years ago. Neandertal-introgressed single nucleotide polymorphisms (aSNPs) have been associated with modern human disease-related traits, which are risk factors for pancreatic ductal adenocarcinoma (PDAC), such as obesity, type 2 diabetes, and inflammation. In this study, we aimed at investigating the role of aSNPs in PDAC in three Eurasian populations. Results The high-coverage Vindija Neandertal genome was used to select aSNPs in non-African populations from 1000 Genomes project phase 3 data. Then, the association between aSNPs and PDAC risk was tested independently in Europeans and East Asians, using existing GWAS data on more than 200.000 individuals.
Keywords in Portuguese
SNPsKeywords in Spanish
Hombre de NeandertalPolimorfismo de Nucleótido Simple
Carcinoma Ductal Pancreático
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