Author | Pereira, Mariana Araújo | |
Author | Schutz, Charlotte | |
Author | Duarte, Beatriz Barreto | |
Author | Barr, David | |
Author | Serra, Klauss Villalva | |
Author | Vinhaes, Caian L. | |
Author | Ward, Amy | |
Author | Meintjes, Graeme | |
Author | Andrade, Bruno B. | |
Access date | 2023-10-06T14:42:12Z | |
Available date | 2023-10-06T14:42:12Z | |
Document date | 2023 | |
Citation | PEREIRA, Mariana Araújo et al. Interplay between systemic inflammation, anemia, and mycobacterial dissemination and its impact on mortality in TB-associated HIV: a prospective cohort study. Front Immunol, p. 1-11, 2023 | en_US |
ISSN | 1664-3224 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/60724 | |
Sponsorship | Programa de Pesquisa Intramuros da Fundação Oswaldo Cruz (BA).
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Capes).
Fundação de Amparo à Pesquisa da Bahia (FAPESB).
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
Conselho de Pesquisa Médica da África do Sul.
Wellcome Trust.
South African Research Chairs Initiative of the Department of Science and Technology and National Research Foundation (NRF) of South Africa.
South African Medical Research Council through its TB and HIV Collaborating Centres Programme with funds received from the National Department of Health. | en_US |
Language | eng | en_US |
Publisher | Frontiers Media | en_US |
Rights | open access | en_US |
Subject in Portuguese | Anemia | en_US |
Subject in Portuguese | HIV | en_US |
Subject in Portuguese | Tuberculose | en_US |
Subject in Portuguese | Mortalidade | en_US |
Subject in Portuguese | Inflamação sistêmica | en_US |
Title | Interplay between systemic inflammation, anemia, and mycobacterial dissemination and its impact on mortality in TB - associated HIV: a prospective cohort study | en_US |
Type | Article | en_US |
DOI | 10.3389/fimmu.2023.1177432. eCollection 2023 | |
Abstract | Introduction: Anemia frequently affects people living with HIV (PLHIV). Nevertheless, the impact of anemia on treatment outcomes of patients with HIV-associated tuberculosis (TB) and the underlying molecular profiles are not
fully characterized. The aim of this study was to investigate the interplay between anemia, the systemic inflammatory profile, dissemination of TB and death in HIVTB patients in an ad hoc analysis of results from a prospective cohort study. Methods: 496 hospitalized PLHIV ≥18 years old, with CD4 count <350 cells/mL and high clinical suspicion of new TB infection were enrolled in Cape Town between 2014-2016. Patients were classified according to anemia severity in non-anemic, mild, moderate, or severe anemia. Clinical, microbiologic, and immunologic data were collected at baseline. Hierarchical cluster analysis, degree of inflammatory perturbation, survival curves and C-statistics analyses were performed. Results: Through the analysis of several clinical and laboratory parameters, we observed that those with severe anemia exhibited greater systemic inflammation, characterized by high concentrations of IL-8, IL-1RA and IL-6. Furthermore, severe anemia was associated with a higher Mtb dissemination score and a higher risk of death, particularly within 7 days of admission. Most of the patients who died had severe anemia and had a more pronounced systemic inflammatory profile. Discussion: Therefore, the results presented here reveal that severe anemia is associated with greater TB dissemination and increased risk of death in PLHIV. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Iniciativa Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER). Salvador, BA, Brasil / Universidade Federal da Bahia. Programa de Pós-Graduação em Patologia Humana e Experimental. Salvador, BA, Brasil / UNIFTC. Curso de Medicina. Salvador, BA, Brasil. | en_US |
Affilliation | Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa). Institute of Infectious Disease and Molecular Medicine. Faculty of Health Sciences. University of Cape Town. Cape Town, South Africa / Programa de Pós-Graduação em Clínica Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Iniciativa Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER). Salvador, BA, Brasil / Programa de Pós-Graduação em Clínica Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil / Universidade Salvador (UNIFACS). Curso de Medicina. Salvador, BA, Brasil. | en_US |
Affilliation | Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa). Institute of Infectious Disease and Molecular Medicine. Faculty of Health Sciences. University of Cape Town. Cape Town, South Africa / Department of Infectious Diseases. NHS Greater Glasgow & Clyde. Glasgow, United Kingdom. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Iniciativa Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER). Salvador, BA, Brasil / Universidade Salvador (UNIFACS). Curso de Medicina. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Iniciativa Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER). Salvador, BA, Brasil / Universidade Federal da Bahia. Programa de Pós-Graduação em Patologia Humana e Experimental. Salvador, BA, Brasil / Fundação Baiana para o Desenvolvimento das Ciências. Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil | en_US |
Affilliation | Department of Medicine. University of Cape Town. Cape Town, South Africa. | en_US |
Affilliation | Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa). Institute of Infectious Disease and Molecular Medicine. Faculty of Health Sciences. University of Cape Town. Cape Town, South Africa. / Programa de Pós-Graduação em Clínica Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Iniciativa Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER). Salvador, BA, Brasil / Universidade Federal da Bahia. Programa de Pós-Graduação em Patologia Humana e Experimental. Salvador, BA, Brasil / UNIFTC. Curso de Medicina. Salvador, BA, Brasil / Programa de Pós-Graduação em Clínica Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil / Universidade Salvador (UNIFACS). Curso de Medicina. Salvador, BA, Brasil / Fundação Baiana para o Desenvolvimento das Ciências. Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | en_US |
Subject | Anemia | en_US |
Subject | HIV | en_US |
Subject | Tuberculosis | en_US |
Subject | Mortality | en_US |
Subject | Systemic inflammation | en_US |
DeCS | Anemia | en_US |
DeCS | HIV | en_US |
DeCS | Tuberculose | en_US |
DeCS | Mortalidade | en_US |