Please use this identifier to cite or link to this item:
https://www.arca.fiocruz.br/handle/icict/60687
HIV-1-HOST INTERACTION IN GUT-ASSOCIATED LYMPHOID TISSUE (GALT): EFFECTS ON LOCAL ENVIRONMENT AND COMORBIDITIES.
Author
Affilliation
National HIV/AIDS Research Center. Istituto Superiore di Sanità. Rome, Italy
National HIV/AIDS Research Center. Istituto Superiore di Sanità. Rome, Italy
National HIV/AIDS Research Center. Istituto Superiore di Sanità. Rome, Italy
National HIV/AIDS Research Center. Istituto Superiore di Sanità. Rome, Italy
National HIV/AIDS Research Center. Istituto Superiore di Sanità. Rome, Italy
National HIV/AIDS Research Center. Istituto Superiore di Sanità. Rome, Italy
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil/Sciences and Technologies for Sustainable Development and One Health. University Campus Bio-Medico of Rome. Rome, Italy
Unit of Medical Statistics and Molecular Epidemiology. University Campus Bio-Medico of Rome. Rome, Italy
National HIV/AIDS Research Center. Istituto Superiore di Sanità. Rome, Italy
National HIV/AIDS Research Center. Istituto Superiore di Sanità. Rome, Italy
National HIV/AIDS Research Center. Istituto Superiore di Sanità. Rome, Italy
National HIV/AIDS Research Center. Istituto Superiore di Sanità. Rome, Italy
National HIV/AIDS Research Center. Istituto Superiore di Sanità. Rome, Italy
National HIV/AIDS Research Center. Istituto Superiore di Sanità. Rome, Italy
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil/Sciences and Technologies for Sustainable Development and One Health. University Campus Bio-Medico of Rome. Rome, Italy
Unit of Medical Statistics and Molecular Epidemiology. University Campus Bio-Medico of Rome. Rome, Italy
National HIV/AIDS Research Center. Istituto Superiore di Sanità. Rome, Italy
Abstract
HIV-1 replication in the gastrointestinal (GI) tract causes severe CD4+ T-cell depletion and disruption of the protective epithelial barrier in the intestinal mucosa, causing microbial translocation, the main driver of inflammation and immune activation, even in people living with HIV (PLWH) taking antiretroviral drug therapy. The higher levels of HIV DNA in the gut compared to the blood highlight the importance of the gut as a viral reservoir. CD4+ T-cell subsets in the gut differ in phenotypic characteristics and differentiation status from the ones in other tissues or in peripheral blood, and little is still known about the mechanisms by which the persistence of HIV is maintained at this anatomical site. This review aims to describe the interaction with key subsets of CD4+ T cells in the intestinal mucosa targeted by HIV-1 and the role of gut microbiome and its metabolites in HIV-associated systemic inflammation and immune activation that are crucial in the pathogenesis of HIV infection and related comorbidities.
Share