Author | Rodrigues, Luana Lorena Silva | |
Author | Pilotto, José Henrique | |
Author | Martinelli, Katrini Guidolini | |
Author | Nicol, Alcina F. | |
Author | Paula, Vanessa Salete de | |
Author | Gheit, Tarik | |
Author | Oliveira, Nathália Silva Carlos | |
Author | Silva-de-Jesus, Carlos | |
Author | Sahasrabuddhe, Vikrant V. | |
Author | Silva, Diane M. da | |
Author | Kast, W. Martin | |
Author | Hardick, Justin | |
Author | Gaydos, Charlotte A. | |
Author | Morgado, Mariza Gonçalves | |
Access date | 2023-09-28T02:24:28Z | |
Available date | 2023-09-28T02:24:28Z | |
Document date | 2023 | |
Citation | RODRIGUES, Luana Lorena Silva et al. Diversity of Anal HPV and Non-HPV Sexually Transmitted Infections and Concordance with Genital Infections in HIV-Infected and HIV-Uninfected Women in the Tapajós Region, Amazon, Brazil. Viruses, v. 15, n. 6, p. 1-14, Jun. 2023. | en_US |
ISSN | 1999-4915 | |
URI | https://www.arca.fiocruz.br/handle/icict/60579 | |
Language | eng | en_US |
Publisher | MDPI | en_US |
Rights | open access | en_US |
Title | Diversity of Anal HPV and Non-HPV Sexually Transmitted Infections and Concordance with Genital Infections in HIV-Infected and HIV-Uninfected Women in the Tapajós Region, Amazon, Brazil | en_US |
Type | Article | en_US |
DOI | 10.3390/v15061328 | |
Abstract | The aim of this study was to classify the diversity of anal HPV and non-HPV sexually transmitted infections (STIs) and compare the concordance between anal and genital infections in HIV-infected and uninfected women living in the Tapajós region, Amazon, Brazil. A cross-sectional study was performed with 112 HIV-uninfected and 41 HIV-infected nonindigenous women. Anal and cervical scrapings were collected and analyzed for HPV, Chlamydia trachomatis (CT), Neisseria
gonorrheae (NG), Trichomonas vaginalis (TV), Mycoplasma genitalium (MG), and Human alphaherpesvirus 2 (HSV-2). The Kappa test evaluated the concordance between anal and genital infections. The overall prevalence of anal HPV infection was 31.3% in HIV-uninfected and 97.6% in HIV-infected women. The most frequent anal high-risk HPV (hrHPV) types were HPV18 and HPV16 in HIV-uninfected women and HPV51, HPV59, HPV31, and HPV58 in HIV-infected women. Anal HPV75 Betapapillomavirus was also identified. Anal non-HPV STIs were identified in 13.0% of all participants. The concordance analysis was fair for CT, MG, and HSV-2, almost perfect agreement for NG, moderate for HPV, and variable for the most frequent anal hrHPV types. Thus, a high prevalence of anal HPV infection with moderate and fair concordance between anal and genital HPV and non-HPV STIs was observed in our study. | en_US |
Affilliation | Universidade Federal do Oeste do Pará. Instituto de Saúde Coletiva. Programa de Pós-Graduação em Ciências da Saúde. Santarém, PA, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa de Pós-Graduação em Medicina Tropical. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Universidade Federal do Espírito Santo. Departamento de Medicina Social. Vitória, ES, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular e Parasitologia. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | International Agency for Research on Cancer. Lyon, France. | en_US |
Affilliation | Universidade Federal Fluminense. Faculdade de Medicina. Departamento de Patologia. Niterói, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | National Cancer Institute. Division of Cancer Prevention. Bethesda, USA. | en_US |
Affilliation | University of Southern California. Department of Obstetrics and Gynecology. Los Angeles, USA / University of Southern California. Norris Comprehensive Cancer Center. Los Angeles, USA. | en_US |
Affilliation | University of Southern California. Department of Obstetrics and Gynecology. Los Angeles, USA / University of Southern California. Norris Comprehensive Cancer Center. Los Angeles, USA / University of Southern California. Department of Molecular Microbiology and Immunology. Los Angeles, USA. | en_US |
Affilliation | Johns Hopkins University School of Medicine. Division of Infectious Diseases, USA. | en_US |
Affilliation | Johns Hopkins University School of Medicine. Division of Infectious Diseases, USA. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | en_US |
Subject | HPV | en_US |
Subject | STI | en_US |
Subject | Anal and cervical infectious | en_US |
Subject | Immune responses | en_US |
e-ISSN | 1999-4915 | |