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3100-12-31
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ANTI-PLASMODIUM VIVAX DUFFY BINDING PROTEIN ANTIBODIES MEASURE EXPOSURE TO MALARIA IN THE BRAZILIAN AMAZON.
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Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais Instituto de Ciências Biológicas. Belo Horizonte, MG, Brazil
Universidade Federal de Mato Grosso. Cuiabá, MT, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou Belo Horizonte, MG, Brazil
Instituto Evandro Chagas. Belém, PA, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou Belo Horizonte, MG, Brazil
Department of Biological Sciences. University of Notre Dame. Notre Dame, Indiana
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais Instituto de Ciências Biológicas. Belo Horizonte, MG, Brazil
Universidade Federal de Mato Grosso. Cuiabá, MT, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou Belo Horizonte, MG, Brazil
Instituto Evandro Chagas. Belém, PA, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou Belo Horizonte, MG, Brazil
Department of Biological Sciences. University of Notre Dame. Notre Dame, Indiana
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou Belo Horizonte, MG, Brazil
Abstract
Plasmodium vivax Duffy binding protein (DBP) is functionally important in the erythrocyte invasion process and provides a logical target for vaccine-mediated immunity. In the current study, we demonstrated that DBP is naturally immunogenic in different populations of the Brazilian Amazon, and the proportions of DBP IgG positive subjects increased with exposure to malaria, reaching a peak in those subjects with long-term exposure (> 15 years) in the Amazon area. This profile of antibody response was significantly different from the one observed for the P. vivax merozoite surface protein 1 (MSP119), which was relatively uniform in areas with markedly different levels of malária transmission. In a small sample of adults with symptomless P. vivax infection, we could not detect any significant correlation between antibodies against these P. vivax proteins and asymptomatic infection. Our study provided na additional insight by demonstrating cumulative exposure as a determinant that acts independently of host age in generation of anti-DBP IgG response
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