Author | Coelho, Mariana | |
Author | Fernandes, Flavia | |
Author | Cardoso, Sandra W. | |
Author | Piedade, Juliana | |
Author | Silva, Marcos Vinícius Torres da | |
Author | Santos, Ricardo | |
Author | Veloso, Valdiléa G. | |
Author | Grinsztejn, Beatriz | |
Author | Pereira, Gustavo Henrique | |
Author | Perazzo, Hugo | |
Access date | 2023-08-31T00:15:12Z | |
Available date | 2023-08-31T00:15:12Z | |
Document date | 2023 | |
Citation | COELHO, Mariana et al. Accuracy and concordance of two-dimensional shear-wave elastography using transient elastography as the reference in chronic viral hepatitis and HIV infection in Rio de Janeiro, Brazil. European Journal of Gastroenterology & Hepatology, v. 35, n. 5, p. 583-590, May 2023. | en_US |
ISSN | 0954-691X | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/60274 | |
Sponsorship | This study was supported by Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) [E-26/201.351/2021 and E-26/203.693/2021 to H.P.] and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) [445957/2020-4 to H.P.]. The funders had no role in study design, data collection and analysis, the decision to publish or the preparation of the article. | en_US |
Language | eng | en_US |
Publisher | Lippincott Williams And Wilkins | en_US |
Rights | restricted access | en_US |
Title | Accuracy and concordance of two-dimensional shear-wave elastography using transient elastography as the reference in chronic viral hepatitis and HIV infection in Rio de Janeiro, Brazil | en_US |
Type | Article | en_US |
DOI | 10.1097/MEG.0000000000002537 | |
Abstract | Objectives: Evaluate the accuracy and agreement of two-dimensional shear-wave elastography (2D-SWE) LOGIQ-S8 with transient elastography in patients from Rio de Janeiro, Brazil. Method: This retrospective study compared liver stiffness measurements (LSMs) using transient elastography (M and XL probes) and 2D-SWE GE-LOGIQ-S8 performed by a single experienced operator on the same day in 348 consecutive individuals with viral hepatitis or HIV infection. Suggestive and highly suggestive compensated-advanced chronic liver disease (c-ACLD) were defined by transient elastography-LSM ≥10 kPa and ≥15 kPa, respectively. Agreement between techniques and accuracy of 2D-SWE using transient elastography-M probe as the reference was assessed. Optimal cut-offs for 2D-SWE were identified using the maximal Youden index.
Results: Three hundred five patients [61.3% male, median age = 51 [interquartile range (IQR), 42-62] years, 24% with hepatitis C virus (HCV) ± HIV; 17% with hepatitis B virus (HBV) ± HIV; 31% were HIV mono-infected and 28% had HCV ± HIV post-sustained virological response] were included. The overall correlation (Spearman's ρ ) was moderate between 2D-SWE and transient elastography-M ( ρ = 0.639) and weak between 2D-SWE and transient elastography-XL ( ρ = 0.566). Agreements were strong ( ρ > 0.800) in people with HCV or HBV mono-infection, and poor in HIV mono-infected ( ρ > 0.400). Accuracy of 2D-SWE for transient elastography-M ≥ 10 kPa [area under the receiver operating characteristic (AUROC) = 0.91 (95% confidence interval [CI], 0.86-0.96); optimal cut-off = 6.4 kPa, sensitivity = 84% (95% CI, 72-92), specificity = 89% (95% CI, 84-92)] and for transient elastography-M ≥ 15 kPa [AUROC = 0.93 (95% CI, 0.88-0.98); optimal cut-off = 7.1 kPa; sensitivity = 91% (95% CI, 75-98), specificity = 89% (95% CI, 85-93)] were excellent. Conclusion: 2D-SWE LOGIQ-S8 system had a good agreement with transient elastography and an excellent accuracy to identify individuals at high risk for c-ACLD. | en_US |
Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research in STD/AIDS (LAPCLIN-AIDS). Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Bonsucesso Federal Hospital. Hepatology Department. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research in STD/AIDS (LAPCLIN-AIDS). Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Bonsucesso Federal Hospital. Hepatology Department. Rio de Janeiro, RJ, Brazil / Estácio de Sá University. School of Medicine. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research in STD/AIDS (LAPCLIN-AIDS). Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research in STD/AIDS (LAPCLIN-AIDS). Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research in STD/AIDS (LAPCLIN-AIDS). Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research in STD/AIDS (LAPCLIN-AIDS). Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Bonsucesso Federal Hospital. Hepatology Department. Rio de Janeiro, RJ, Brazil / Estácio de Sá University. School of Medicine. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research in STD/AIDS (LAPCLIN-AIDS). Rio de Janeiro, RJ, Brazil. | en_US |
Subject | Chronic viral hepatitis | en_US |
Subject | HIV infection | en_US |
Subject | Two-dimensional shear-wave elastography (2D-SWE) | en_US |
Subject | Patients | en_US |
e-ISSN | 1473-5687 | |
Embargo date | 2030-12-31 | |