Author | Paixão, Ariane Gomes | |
Author | Almeida, Marcos Abreu | |
Author | Correia, Roberta Espírito Santo | |
Author | Kamiensky, Beatriz Brittes | |
Author | Zancopé-Oliveira, Rosely Maria | |
Author | Lazera, Márcia dos Santos | |
Author | Wanke, Bodo | |
Author | Lamas, Cristiane da Cruz | |
Access date | 2023-08-26T15:24:35Z | |
Available date | 2023-08-26T15:24:35Z | |
Document date | 2023 | |
Citation | PAIXÃO, Ariane Gomes et al. Histoplasmosis at a Reference Center for Infectious Diseases in Southeast Brazil: Comparison between HIV-Positive and HIV-Negative Individuals. Tropical Medicine and Infectious Disease, v. 8, p. 1-11, Apr. 2023. | en_US |
ISSN | 2414-6366 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/60237 | |
Description | Institutional Review Board Statement: The study was approved by the INI Research Ethics Committee; under CAAE number 98094718.4.0000.5262, on 10 December 2018. Informed Consent Statement: This is a retrospective study and our local Ethics Committee approved it without the need for informed consent. Data Availability Statement: Data has not been made publicly available due to ethical reasons. Acknowledgments: We thank Julio Castro Alves de Lima e Silva for statistical analysis, and we thank all colleagues involved in patient care. | en_US |
Sponsorship | RMZ-O is partially supported by grants from CNPq 308315/2021-9 and FAPERJ E-26/200.381/2023. | en_US |
Language | eng | en_US |
Publisher | MDPI | en_US |
Rights | open access | en_US |
Title | Histoplasmosis at a Reference Center for Infectious Diseases in Southeast Brazil: Comparison between HIV-Positive and HIV-Negative Individuals | en_US |
Type | Article | en_US |
DOI | 10.3390/tropicalmed8050271 | |
Abstract | Objectives: Histoplasmosis is a systemic mycosis, present globally. We aimed to describe cases of histoplasmosis (Hc) and to establish a risk profile associated with Hc in HIV-infected patients (HIV+). Methods: This was a retrospective study of patients with a clinical laboratory diagnosis of Hc. Data were fed into REDCap, and statistical analysis was performed with R. Results: We included 99 records, 65 HIV+ and 34 HIV−. Average age was 39 years. Median time from onset to diagnosis was 8 weeks in HIV− and 22 weeks in HIV+. Disseminated histoplasmosis occurred in 79.4% of HIV+, vs. 36.4% of HIV− patients. Median CD4 count was 70. Co-infection with tuberculosis was present in 20% of HIV+ patients. Blood cultures were positive in 32.3% of HIV+ vs. 11.8% of HIV−(p = 0.025) patients; bone marrow culture was positive in 36.9% vs. 8.8% (p = 0.003). Most HIV+ patients (71.4%) were hospitalized. On univariate analysis, anemia, leukopenia, intensive care, use of vasopressors and mechanical ventilation were associated with death in HIV+ patients. Conclusions: Most of our patients with histoplasmosis were HIV+, presenting advanced AIDS. Diagnosis was late in HIV+ patients, and they frequently presented disseminated Hc, required hospitalization, and died. Early screening for Hc in HIV+ and drug-induced immunosuppressed patients is crucial. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil / Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brazil. | en_US |
Subject | Histoplasmosis | en_US |
Subject | Brazil | en_US |
Subject | Epidemiology | en_US |
Subject | HIV-positive | en_US |
Subject | AIDS | en_US |
Subject | Immunosuppression | en_US |
Subject | Culture | en_US |
Subject | Serology | en_US |
Subject | Mortality | en_US |