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Autor | Andrade, Laila de Carvalho | |
Autor | Majerowicz, David | |
Autor | Oliveira, Pedro L. | |
Autor | Guarneri, Alessandra Aparecida | |
Fecha de acceso | 2023-08-10T18:01:36Z | |
Fecha de disponibilización | 2023-08-10T18:01:36Z | |
Fecha de publicación | 2023 | |
Referencia | ANDRADE, Laila de Carvalho et al. Alterations in energy metabolism of Rhodnius prolixus induced by Trypanosoma rangeli infection. Insect Biochemistry and Molecular Biology, v. 159, p. 103987, 2023. doi.org/10.1016/j.ibmb.2023.103987 | en_US |
ISSN | 1879-0240 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/60035 | |
Idioma | eng | en_US |
Editor | Elsevier Ltd. | en_US |
Derechos de autor | restricted access | en_US |
Título | Alterations in energy metabolism of Rhodnius prolixus induced by Trypanosoma rangeli infection | en_US |
Tipo del documento | Article | en_US |
Resumen en Inglés | Trypanosoma rangeli is a protozoan parasite that infects triatomines and mammals in the Americas, producing mixed infections with Trypanosoma cruzi, the etiological agent of Chagas disease. The former parasite is not pathogenic to humans, but has different levels of pathogenicity, as well as causing physiological and behavioral alterations, to its invertebrate hosts. In this study, we measured locomotory activity, and the glyceride accumulation profile in the hemolymph and fat body, as well as the expression of key genes related to triglyceride metabolism, of Rhodnius prolixus nymphs infected with T. rangeli. We found that the locomotory activity of the insects was correlated with the amount of triglycerides in the fat body. Infected nymphs had increased activity when starved, and also had an accumulation of glycerides in the fat body and hemolymph. These alterations were also associated with a higher expression of the diacylglycerol acyltransferase, lipophorin and lipophorin receptor genes in the fat body. We infer that T. rangeli is able to alter the energetic processes of its invertebrate host, in order to increase the availability of lipids to the parasite, which, in turn modifies the activity levels of the insect. These alterations are discussed with regard to their potential to increase the transmission rate of the parasite. | en_US |
Afiliación | Fundação Oswaldo Cruz. Instituto René Rachou. Comportamento de Vetores e Interação com Patógenos. Belo Horizonte, MG, Brazil | en_US |
Afiliación | Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Departamento de Biotecnologia Farmacêutica. Rio de Janeiro, RJ, Brazil/Universidade do Estado do Rio de Janeiro. Programa de Pós-Graduação em Biociências. Rio de Janeiro, RJ, Brazil/Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular. Brasil | en_US |
Afiliación | Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brazil/Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular. Brasil | en_US |
Afiliación | Fundação Oswaldo Cruz. Instituto René Rachou. Comportamento de Vetores e Interação com Patógenos. Belo Horizonte, MG, Brazil/Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular. Brasil | en_US |
Palavras clave en Inglês | Fat body | en_US |
Palavras clave en Inglês | Hemolymph | en_US |
Palavras clave en Inglês | Lipids | en_US |
Palavras clave en Inglês | Rhodnius prolixus | en_US |
Palavras clave en Inglês | Trypanosoma rangeli | en_US |
Fecha de embargo | 3100-12-31 |