Author | Moreira, Liliani Salum Alves | |
Author | Piló-Veloso, Dorila | |
Author | Mello, Rômulo Teixeira de | |
Author | Coelho, Paulo Marcos Zech | |
Author | Nelson, David Lee | |
Access date | 2023-07-27T14:06:38Z | |
Available date | 2023-07-27T14:06:38Z | |
Document date | 2007 | |
Citation | MOREIRA, Liliani Salum Alves et al. A study of the activity of 2-(alkylamino)-1-phenyl-1-ethanethiosulfuric acids against infection by Schistosoma mansoni in a murine model. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 101, n. 4, p. 385-390, 2007. doi.org/10.1016/j.trstmh.2006.06.006 | en_US |
ISSN | 0035-9203 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/59806 | |
Language | eng | en_US |
Publisher | Royal Society of Tropical Medicine and Hygiene | en_US |
Rights | restricted access | en_US |
Title | A study of the activity of 2-(alkylamino)-1-phenyl-1-ethanethiosulfuric acids against infection by Schistosoma mansoni in a murine model | en_US |
Type | Article | en_US |
DOI | 10.1016/j.trstmh.2006.06.006 | |
Abstract | The schistosomicidal. activities of seven 2-(alkytamino)-1-phenyl-1-ethanethiosulfuric acids (1a-g) (R = propyl, isopropyl, butyl, isobutyl, t-butyl, sec-butyl, cyclohexyl, respectively) were determined in female Swiss mice infected with Schistosoma mansoni. The compounds were administered in a single oral dose of 800 mg/kg to groups of 15 mice infected with 50 cercariae each. All the compounds were found to be active, a high animal mortality being observed with 1e. These compounds have a high specificity against female worms (64-100% reduction vs. 33-61% reduction in mate worms). The test was repeated, a 400-mg/kg sub-dose of 1f also being tested, and similar results were observed. A 94% reduction in the number of female worms was observed when compound 1c was administered in a single 800-mg/kg dose to animals infected with 80 cercariae. Finally, the test was repeated with single 800 mg/kg oral doses of compounds 1e (highly purified) and 1f and a 400-mg/kg sub-dose of 1c. The toxicity of le was confirmed, while the animals that received 1c and 1f presented reductions in the worm Loads corresponding to 45.9% (male worms) and 84.8% (female worms) for 1c and 50.4% (male worms) and 94.2% (female worms) for 1f. | en_US |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Química. Belo Horizonte, MG, Brazil | en_US |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Química. Belo Horizonte, MG, Brazil | en_US |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Belo Horizonte, MG, Brazil | en_US |
Affilliation | Fundação Osvaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil/Santa Casa de Misericórdia de Belo Horizonte. Belo Horizonte, MG, Brazil | en_US |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Alimentos. Belo Horizonte, MG, Brazil | en_US |
Subject | schistosomiasis | en_US |
Subject | Schistosoma mansoni | en_US |
Subject | aminoalkanethiosulfuric acid | en_US |
Subject | preclinical drug evaluation | en_US |
Subject | drug resistance | en_US |
Subject | toxicity | en_US |
Embargo date | 3100-12-31 | |