Author | Matos, Bruno Moises de | |
Author | Stimamiglio, Marco Augusto | |
Author | Correa, Alejandro | |
Author | Robert, Anny Waloski | |
Access date | 2023-07-25T15:17:10Z | |
Available date | 2023-07-25T15:17:10Z | |
Document date | 2023 | |
Citation | MATOS, Bruno Moises de et al. Human pluripotent stem cell-derived extracellular vesicles: from now to the future. World J. Stem Cells., v. 15, n. 5, p. 453-465, 2023. | en_US |
ISSN | 1948-0210 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/59749 | |
Language | eng | en_US |
Publisher | Baishideng Publishing Group | en_US |
Rights | open access | en_US |
Subject in Portuguese | Terapia Livre de Células | en_US |
Title | Human pluripotent stem cell-derived extracellular vesicles: from now to the future | en_US |
Type | Article | en_US |
DOI | https://www.10.4252/wjsc.v15.i5.453 | |
Abstract | Extracellular vesicles (EVs) are nanometric particles that enclose cell-derived bioactive molecules in a lipid bilayer and serve as intercellular communication tools. Accordingly, in various biological contexts, EVs are reported to engage in immune modulation, senescence, and cell proliferation and differentiation. Therefore, EVs could be key elements for potential off-the-shelf cell-free therapy. Little has been studied regarding EVs derived from human pluripotent stem cells (hPSC-EVs), even though hPSCs offer good opportunities for induction of tissue regeneration and unlimited proliferative ability. In this review article, we provide an overview of studies using hPSC-EVs, focusing on identifying the conditions in which the cells are cultivated for the isolation of EVs, how they are characterized, and applications already demonstrated. The topics reported in this article highlight the incipient status of the studies in the field and the significance of hPSC-EVs’ prospective applications as PSC-derived cell-free therapy products. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil. | en_US |
Subject | Pluripotent Stem Cells | en_US |
Subject | Extracellular Vesicles | en_US |
Subject | Exosomes | en_US |
Subject | Cell-free Therapy | en_US |
Subject in Spanish | Células Madre Pluripotentes | en_US |
Subject in Spanish | Vesículas Extracelulares | en_US |
Subject in Spanish | Exosomas | en_US |
Subject in French | Cellules souches pluripotentes | en_US |
Subject in French | Vésicules extracellulaires | en_US |
Subject in French | Exosomes | en_US |
DeCS | Células-Tronco Pluripotentes | en_US |
DeCS | Vesículas Extracelulares | en_US |
DeCS | Exossomos | en_US |