Author | Fabri, Rodrigo Luiz | |
Author | Coimbra, Elaine Soares | |
Author | Almeida, Ana C. | |
Author | Siqueira Filho, Ezequias Pessoa | |
Author | Alves, Tânia Maria Almeida | |
Author | Zani, Carlos Leomar | |
Author | Scio, Elita | |
Access date | 2023-07-11T17:03:23Z | |
Available date | 2023-07-11T17:03:23Z | |
Document date | 2012 | |
Citation | FABRI, Rodrigo Luiz et al. Essential oil of Mitracarpus frigidus as a potent source of bioactive compounds. An. Acad. Bras. Ciênc., v. 84, n. 4, p. 1073-1080, 2012. doi.org/10.1590/S0001-37652012000400021 | en_US |
ISSN | 0001-3765 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/59511 | |
Abstract in Portuguese | In our previous work (Fabri et al. 2009), we showed that different extracts of Mitracarpus frigidus had significant antibacterial, antifungal and leishmanicidal activities. In order to increase our knowledge about this species, this work assesses the chemical composition and the in vitro biological activity of its essential oil. Thus, the essential oil obtained by hydrodistillation of the aerial parts of M. frigidus was analyzed by GC/MS. Among several compounds detected, 11 were identified, being linalool and eugenol acetate the major components. The essential oil exhibited a moderate antibacterial effect against Staphyloccocus aureus, Bacillus cereus, Pseudomonas aeruginosa and Enterobacter cloacae (MIC 250 mu g/mL). On the other hand, it showed a strong antifungal effect against Cryptoccocus neoformans (MIC 8 mu g/mL) and Candida albicans (MIC 63 mu g/mL). Expressive activity against L. major and L. amazonensis promastigote forms with IC50 values of 47.2 and 89.7 mu g/mL, respectively, were also observed. In addition, the antioxidant activity was investigated through DPPH radical-scavenging and showed a significative activity with IC50 of 38 mu g/mL. The cytotoxicity against Artemia salina was moderate with LC50 of 88 mu g/mL. The results presented here are the first report on the chemical composition and biological properties of M. frigidus essential oil | en_US |
Language | eng | en_US |
Publisher | Academia Brasileira de Ciências | en_US |
Rights | open access | en_US |
Subject in Portuguese | Mitracarpus frigidus | en_US |
Subject in Portuguese | óleo essencial | en_US |
Subject in Portuguese | antimicrobiano | en_US |
Subject in Portuguese | leishmanicida | en_US |
Subject in Portuguese | citotoxidade | en_US |
Title | Essential oil of Mitracarpus frigidus as a potent source of bioactive compounds | en_US |
Type | Article | en_US |
DOI | https://doi.org/10.1590/S0001-37652012000400021 | |
Abstract | In our previous work (Fabri et al. 2009), we showed that different extracts of Mitracarpus frigidus had significant antibacterial, antifungal and leishmanicidal activities. In order to increase our knowledge about this species, this work assesses the chemical composition and the in vitro biological activity of its essential oil. Thus, the essential oil obtained by hydrodistillation of the aerial parts of M. frigidus was analyzed by GC/MS. Among several compounds detected, 11 were identified, being linalool and eugenol acetate the major components. The essential oil exhibited a moderate antibacterial effect against Staphyloccocus aureus, Bacillus cereus, Pseudomonas aeruginosa and Enterobacter cloacae (MIC 250 mu g/mL). On the other hand, it showed a strong antifungal effect against Cryptoccocus neoformans (MIC 8 mu g/mL) and Candida albicans (MIC 63 mu g/mL). Expressive activity against L. major and L. amazonensis promastigote forms with IC50 values of 47.2 and 89.7 mu g/mL, respectively, were also observed. In addition, the antioxidant activity was investigated through DPPH radical-scavenging and showed a significative activity with IC50 of 38 mu g/mL. The cytotoxicity against Artemia salina was moderate with LC50 of 88 mu g/mL. The results presented here are the first report on the chemical composition and biological properties of M. frigidus essential oil | en_US |
Affilliation | Universidade Federal de Juiz de Fora. Instituto de Ciências Biológicas. Departamento de Bioquímica. Juiz de Fora, MG, Brazil | en_US |
Affilliation | Universidade Federal de Juiz de Fora. Instituto de Ciências Biológicas. Departamento de Parasitologia, Microbiologia e Imunologia. Juiz de Fora, MG, Brazil | en_US |
Affilliation | Universidade Federal de Juiz de Fora. Instituto de Ciências Biológicas. Departamento de Parasitologia, Microbiologia e Imunologia. Juiz de Fora, MG, Brazil | en_US |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, Brasil | en_US |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, Brasil | en_US |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, Brasil | en_US |
Affilliation | Universidade Federal de Juiz de Fora. Instituto de Ciências Biológicas. Departamento de Bioquímica. Juiz de Fora, MG, Brazil | en_US |
Subject | Mitracarpus frigidus | en_US |
Subject | ssential oil | en_US |
Subject | antileishmanial | en_US |
Subject | cytotoxicity | en_US |