Author | Castanheira, Laura Gomes | |
Author | Castro, Juciane Maria de Andrade | |
Author | Martins Filho, Olindo de Assis | |
Author | Nicoli, Jacques Robert | |
Author | Vieira, Leda Quercia | |
Author | Afonso, Luis Carlos Crocco | |
Access date | 2023-07-10T17:56:33Z | |
Available date | 2023-07-10T17:56:33Z | |
Document date | 2007 | |
Citation | CASTANHEIRA, Laura Gomes et al. Lactobacillus delbrueckii as a potential skin adjuvant for induction of type 1 immune responses. Frontiers in Bioscience, v. 12, p. 1300-1307, 2007. | en_US |
ISSN | 1093-4715 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/59487 | |
Language | eng | en_US |
Publisher | IMR Press | en_US |
Rights | restricted access | en_US |
Title | Lactobacillus delbrueckii as a potential skin adjuvant for induction of type 1 immune responses | en_US |
Type | Article | en_US |
DOI | 10.2741/2148 | |
Abstract | We evaluated the ability of Lactobacillus delbrueckii UFV H2b20, a probiotic candidate, to stimulate the production of inflammatory cytokines and to induce macrophage activation and Th1 differentiation in peripheral blood mononuclear cells ( PBMC) from healthy volunteers. Our results show that PBMC stimulated with heat- killed Lact. delbrueckii produced elevated levels of IL- 12, IFN-. and TNF-alpha but no IL-10. IFN-gamma production was IL- 12 dependent with NK cells as the main source. Furthermore, PBMC infected with Leishmania amazonensis presented elevated microbicidal activity when co-incubated with Lact. delbrueckii. Finally, Lact. delbrueckii was capable of inducing in vitro differentiation of L. amazonensis- specific Th1 cells. These findings suggest that this probiotic may be used as an adjuvant in vaccination protocols. | en_US |
Affilliation | Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil. | en_US |
Affilliation | Universidade Federal de Ouro. Instituto de Ciências Exatas e Biológicas. Departamento de Ciências Biológicas. Preto, Ouro Preto, MG, Brasil. | en_US |
Affilliation | Universidade Federal de Ouro. Instituto de Ciências Exatas e Biológicas. Departamento de Ciências Biológicas. Preto, Ouro Preto, MG, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil. | en_US |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte MG, Brasil. | en_US |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte MG, Brasil. | en_US |
Affilliation | Universidade Federal de Ouro. Instituto de Ciências Exatas e Biológicas. Departamento de Ciências Biológicas. Preto, Ouro Preto, MG, Brasil. | en_US |
Subject | Lactobacillus | en_US |
Subject | Probiotics | en_US |
Subject | Adjuvant | en_US |
Embargo date | 2099-12-31 | |