Author | Fritsch, Hegger | |
Author | Moreno, Keldenn | |
Author | Lima, Italo Andrade Barbosa | |
Author | Santos, Cleiton Silva | |
Author | Costa, Bernardo Gratival Gouvea | |
Author | Almeida, Breno Lima de | |
Author | Santos, Ronald Alves dos | |
Author | Francisco, Marcos Vinicius Lima de Oliveira | |
Author | Sampaio, Maria Paula Souza | |
Author | Lima, Maricelia Maia de | |
Author | Pereira, Felicidade Mota | |
Author | Fonseca, Vagner | |
Author | Tosta, Stephane | |
Author | Xavier, Joilson | |
Author | Oliveira, Carla de | |
Author | Adelino, Talita | |
Author | Mello, Arabela Leal e Silva de | |
Author | Gräf, Tiago | |
Author | Alcantara, Luiz Carlos Junior | |
Author | Giovanetti, Marta | |
Author | Siqueira, Isadora Cristina de | |
Access date | 2023-06-30T14:47:23Z | |
Available date | 2023-06-30T14:47:23Z | |
Document date | 2023 | |
Citation | FRITSCH, Hegger et al. Phylogenetic reconstructions reveal the circulation of a novel Dengue Virus-1V clade and the persistence of a Dengue Virus-2 III genotype in northeast Brazil. Viruses, v. 15, n. 1073, p. 1-12, 2023. | en_US |
ISSN | 1999-4915 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/59305 | |
Language | por | en_US |
Publisher | MDPI | en_US |
Rights | open access | en_US |
Title | Phylogenetic reconstructions reveal the circulation of a novel Dengue virus-1V clade and the persistence of a Dengue Virus-2 III genotype in northeast Brazil | en_US |
Type | Article | en_US |
DOI | https://doi.org/10.3390/ v15051073 | |
Abstract | Dengue fever is among the most significant public health concerns in Brazil. To date, the highest number of Dengue notifications in the Americas has been reported in Brazil, with cases accounting for a total number of 3,418,796 reported cases as of mid-December 2022. Furthermore, the northeastern region of Brazil registered the second-highest incidence of Dengue fever in 2022. Due to the alarming epidemiological scenario, in this study, we used a combination of portable whole-genome sequencing, phylodynamic, and epidemiological analyses to reveal a novel DENV-1 genotype V clade and the persistence of DENV-2 genotype III in the region. We further report the presence of non-synonymous mutations associated with non-structural domains, especially the NS2A (non-structural protein 2A), as well as describe synonymous mutations in envelope and membrane proteins, distributed differently between clades. However, the absence of clinical data at the time of collection and notification, as well as the impossibility of monitoring patients in order to observe worsening or death, restricts our possibility of correlating mutational findings with possible clinical prognoses. Together, these results reinforce the crucial role of genomic surveillance to follow the evolution of circulating DENV strains and understand their spread across the region through interregional importation events, likely mediated by human mobility, and also the possible impacts on public health and outbreak management. | en_US |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brasil. | en_US |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Secretaria Municipal de Saúde de Feira de Santana. Feira de Santana, BA, Brasil. / Universidade Estadual de Feira de Santana. Departamento de Saúde. Feira de Santana, BA, Brasil. | en_US |
Affilliation | Laboratório Central de Saúde Pública Professor Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Organização Pan-Americana da Saúde. Brasília, DF, Brasil. / Organização Mundial da Saúde. Brasília, DF, Brasil. | en_US |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brasil. | en_US |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavívirus. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Ezequiel Dias. Laboratório Central de Saúde Pública do Estado de Minas Gerais. Belo Horizonte, MG, Brasil. | en_US |
Affilliation | Universidade Estadual de Feira de Santana. Departamento de Saúde. Feira de Santana, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. / Sciences and Technologies for Sustainable Development and One Health. University of Campus Bio-Medico. Rome, Italy. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Subject | Dengue Virus | en_US |
Subject | Dengue Fever | en_US |
Subject | Viral Nonstructural Proteins | en_US |
Subject | Genomics | en_US |
Subject | Brazil | en_US |
Subject in Spanish | Virus del Dengue | en_US |
Subject in Spanish | Proteínas no Estructurales Virales | en_US |
Subject in Spanish | Genómica | en_US |
Subject in French | Virus de la dengue | en_US |
Subject in French | Protéines virales non structurales | en_US |
Subject in French | Génomique | en_US |
Subject in French | Brasil | en_US |
DeCS | Vírus da Dengue | en_US |
DeCS | Febre da Dengue | en_US |
DeCS | Proteínas não Estruturais Virais | en_US |
DeCS | Genômica | en_US |
DeCS | Brasil | en_US |