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2099-12-31
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PROVIRAL LOAD AND THE BALANCE OF SERUM CYTOCINES IN HTLV-1-ASYMPTOMATIC INFECTION AND IN HTLV-1-ASSOCIATED MYELOPATHY/TROPICAL SPASTIC PARAPARESIS (HAM/TSP)
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Universidade Federal de Minas Gerais. Faculdade de Medicina. Programa de Pós-Graduacão em Infectologia e Medicina Tropical Minas Gerais. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Faculdade de Medicina. Programa de Pós-Graduacão em Infectologia e Medicina Tropical Minas Gerais. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Faculdade de Medicina. Programa de Pós-Graduacão em Infectologia e Medicina Tropical Minas Gerais. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Faculdade de Medicina. Programa de Pós-Graduacão em Infectologia e Medicina Tropical Minas Gerais. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil
Estado de Minas Gerais. Fundacão Centro de Hematologia e Hemoterapia de Minas Gerais. Belo Horizonte, MGs, Brazil
Hospital Sarah Kubitschek. Belo Horizonte, MG, Brazil
Estado de Minas Gerais. Fundacão Centro de Hematologia e Hemoterapia de Minas Gerais. Belo Horizonte, MG, Brazil/Faculdade da Saúde e Ecologia Humana. Vespasiano, MG, Brazil
Universidade Federal de Minas Gerais. Faculdade de Medicina. Programa de Pós-Graduacão em Infectologia e Medicina Tropical Minas Gerais. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Faculdade de Medicina. Programa de Pós-Graduacão em Infectologia e Medicina Tropical Minas Gerais. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Faculdade de Medicina. Programa de Pós-Graduacão em Infectologia e Medicina Tropical Minas Gerais. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Faculdade de Medicina. Programa de Pós-Graduacão em Infectologia e Medicina Tropical Minas Gerais. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil
Estado de Minas Gerais. Fundacão Centro de Hematologia e Hemoterapia de Minas Gerais. Belo Horizonte, MGs, Brazil
Hospital Sarah Kubitschek. Belo Horizonte, MG, Brazil
Estado de Minas Gerais. Fundacão Centro de Hematologia e Hemoterapia de Minas Gerais. Belo Horizonte, MG, Brazil/Faculdade da Saúde e Ecologia Humana. Vespasiano, MG, Brazil
Universidade Federal de Minas Gerais. Faculdade de Medicina. Programa de Pós-Graduacão em Infectologia e Medicina Tropical Minas Gerais. Belo Horizonte, MG, Brazil
Abstract
This study compared the proviral load and the plasma cytokine profiles (interleukin-IL-2, IL-4, IL-6, IL-10, TNF-alpha, IFN-gamma) in 87 HTLV-1-infected individuals, including 28 with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), 32 with possible pHAM/TSP and 27 asymptomatic carriers (AC). The control group was composed by 21 HTLV-1-seronegative individuals. Our finding demonstrated that HAM/TSP group presented higher proviral load as compared to all other HTLV-1 groups (p < 0.0001). The HAM/TSP group showed higher serum concentration of IL-6 (p = 0.0009) as compared to all other groups. Moreover, higher serum concentration of IFN-gamma (p=0.0118) and IL-4 (p=0.0166) were observed in HAM/TSP group as compared to the healthy controls. Additionally, the HAM/TSP group also showed higher serum concentration of TNF-alpha (p = 0.0239) and IFN-gamma (p = 0.0118) as compared to AC. No differences in the serum concentration of IL-2 and IL-10 were observed among the groups. The analysis of cytokine balance demonstrated that HAM/TSP presented higher pro-inflammatory profile with enhanced IFN-gamma/IL-10 and IFN-gamma/IL-4 ratio as compared to AC and pHAM/TSP. Further analysis pointed out to a positive correlation between the IFN-gamma response and the proviral load in AC. Conversely, a negative association between TNE-alpha and IL-2 with the proviral load was the hallmark of HAM/TSP group. These findings suggested that the proviral load and the pro-inflammatory cytokine profile may be independent events in the peripheral blood of HAM/TSP individuals. The knowledge about the existence of individual virological/immunological behavior upon HTLV-1 infection, may guide to the establishment of more effective therapeutic interventions. (C) 2012 Elsevier B.V. All rights reserved
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