Author | Santos, John Lenon de Souza | |
Author | Araújo, Cecília de Almeida | |
Author | Rocha, Clarissa Araújo Gurgel | |
Author | Costa-Ferro, Zaquer Suzana Munhoz | |
Author | Souza, Bruno Solano de Freitas | |
Access date | 2023-06-15T16:50:33Z | |
Available date | 2023-06-15T16:50:33Z | |
Document date | 2023 | |
Citation | SANTOS, John Lenon de Souza et al. Modeling autism spectrum disorders with induced pluripotent stem cell-derived brain organoids. Biomolecules, v. 13, n. 260, p. 1-16, 2023. | en_US |
ISSN | 2218-273X | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/59046 | |
Sponsorship | Fundação Maria Emília (FME). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). | en_US |
Language | eng | en_US |
Publisher | MDPI | en_US |
Rights | open access | en_US |
Subject in Portuguese | Transtorno do espectro autista | en_US |
Subject in Portuguese | Organoides cerebrais | en_US |
Subject in Portuguese | Célula-tronco pluripotente | en_US |
Title | Modeling autism spectrum disorders with induced pluripotent stem cell-derived brain organoids | en_US |
Type | Article | en_US |
DOI | 10.3390/biom13020260 | |
Abstract | Autism spectrum disorders (ASD) are a group of complex neurodevelopmental disorders that affect communication and social interactions and present with restricted interests and repetitive behavior patterns. The susceptibility to ASD is strongly influenced by genetic/heritable factors; however, there is still a large gap in understanding the cellular and molecular mechanisms underlying the neurobiology of ASD. Significant progress has been made in identifying ASD risk genes and the possible convergent pathways regulated by these gene networks during development. The breakthrough of cellular reprogramming technology has allowed the generation of induced pluripotent stem cells (iPSCs) from individuals with syndromic and idiopathic ASD, providing patient-specific cell models for mechanistic studies. In the past decade, protocols for developing brain organoids from these cells have been established, leading to significant advances in the in vitro reproducibility of the early steps of human brain development. Here, we reviewed the most relevant literature regarding the application of brain organoids to the study of ASD, providing the current state of the art, and discussing the impact of such models on the field, limitations, and opportunities for future development. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil. | en_US |
Affilliation | Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Instituto de Pesquisa e Ensino D'OR. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Instituto de Pesquisa e Ensino D'OR. Salvador, BA, Brasil. | en_US |
Affilliation | Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Instituto de Pesquisa e Ensino D'OR. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Instituto de Pesquisa e Ensino D'OR. Salvador, BA, Brasil. | en_US |
Subject | Autism spectrum disorder | en_US |
Subject | Brain organoids | en_US |
Subject | Pluripotent stem cell | en_US |
DeCS | Transtorno do Espectro Autista | en_US |
DeCS | Organoides | en_US |
DeCS | Células-Tronco Pluripotentes Induzidas | en_US |