Author | Dourado, Mauricio Rocha | |
Author | Elseragy, Amr | |
Author | Costa, Bruno Cesar da | |
Author | Téo, Fábio Haach | |
Author | Guimarães, Gustavo Narvaes | |
Author | Machado, Renato Assis | |
Author | Risteli, Maija | |
Author | Wahbi, Wafa | |
Author | Rocha, Clarissa Araujo Gurgel | |
Author | Paranaíba, Lívia Máris Ribeiro | |
Author | Arriagada, Wilfredo Alejandro González | |
Author | Silva, Sabrina Daniela da | |
Author | Rangel, Ana Lucia Carrinho Ayroza | |
Author | Marques, Marcelo Rocha | |
Author | Rossa Junior, Carlos | |
Author | Salo, Tuula | |
Author | Coletta, Ricardo D. | |
Access date | 2023-06-13T17:16:57Z | |
Available date | 2023-06-13T17:16:57Z | |
Document date | 2023 | |
Citation | DOURADO, Mauricio Rocha et al. Stress induced phosphoprotein 1 overexpression controls proliferation, migration and invasion and is associated with poor survival in oral squamous cell carcinoma. Frontiers in Oncology, v. 12, p. 1-15, 2023. | en_US |
ISSN | 2234-943X | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/59004 | |
Sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP).
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
Universities of Oulu and Helsinki.
Juselius Foundation, and Oulu and Helsinki University Hospital. | en_US |
Language | eng | en_US |
Publisher | Frontiers Media | en_US |
Rights | open access | en_US |
Subject in Portuguese | MIR-218-5p | en_US |
Subject in Portuguese | STIP1 | en_US |
Subject in Portuguese | Invasão | en_US |
Subject in Portuguese | Câncer bucal | en_US |
Subject in Portuguese | Prognóstico | en_US |
Subject in Portuguese | Proliferação | en_US |
Title | Stress induced phosphoprotein 1 overexpression controls proliferation, migration and invasion and is associated with poor survival in oral squamous cell carcinoma | en_US |
Type | Article | en_US |
DOI | 10.3389/fonc.2022.1085917 | |
Abstract | Objective: Although there have been remarkable achievements in the molecular landscape of oral squamous cell carcinoma (OSCC) in recent years, bringing advances in the understanding of its pathogenesis, development and progression, little has been applied in the prognosis and choosing the optimal treatment. In this study, we explored the influence of the stress induced phosphoprotein 1 (STIP1), which is frequently reported to be highly expressed in many cancers, in OSCCs. Methods: STIP1 expression was assessed in the TCGA database and in two independent cohorts by immunohistochemistry. Knockdown strategy was applied in OSCC cell lines to determine the impact of STIP1 on viability, proliferation, migration and invasion. The zebrafish model was applied for studying tumor formation and metastasis in vivo. The association of STIP1 and miR-218-5p was explored by bioinformatics and mimics transfection.
Results: STIP1 was highly expressed in OSCCs and significantly associated with shortened survival and higher risk of recurrence. STIP1 down-regulation decreased proliferation, migration and invasion of tumor cells, and reduced the number of metastases in the Zebrafish model. STIP1 and miR-218-5p were inversely expressed, and the transfection of miR-218-5p mimics into OSCC cells decreased STIP1 levels as well as proliferation, migration and invasion.
Conclusion: Our findings show that STIP1 overexpression, which is inversely associated with miR-218-5p levels, contributes to OSCC aggressiveness by controlling proliferation, migration and invasion and is a determinant of poor prognosis. | en_US |
Affilliation | Universidade de Campinas. Faculdade de Odontologia de Piracicaba. Departamento de Diagnóstico Oral. Programa de Pós-Graduação em Biologia Oral. Piracicaba, SP, Brasil. | en_US |
Affilliation | Cancer and Translational Medicine Research Unit. Faculty of Medicine and Medical Research Center. Oulu University Hospital. University of Oulu. Oulu, Finland. | en_US |
Affilliation | Universidade de Campinas. Faculdade de Odontologia de Piracicaba. Departamento de Diagnóstico Oral. Programa de Pós-Graduação em Biologia Oral. Piracicaba, SP, Brasil. | en_US |
Affilliation | Universidade de Campinas. Faculdade de Odontologia de Piracicaba. Departamento de Diagnóstico Oral. Programa de Pós-Graduação em Biologia Oral. Piracicaba, SP, Brasil. | en_US |
Affilliation | Universidade de Campinas. Faculdade de Odontologia de Piracicaba. Departamento de Biociências. Programa de Pós-Graduação em Biologia Oral. Piracicaba, SP, Brasil. | en_US |
Affilliation | Universidade de Campinas. Faculdade de Odontologia de Piracicaba. Departamento de Diagnóstico Oral. Programa de Pós-Graduação em Biologia Oral. Piracicaba, SP, Brasil / Universidade de São Paulo. Hospital de Reabilitação de Anomalias Craniofaciais. Bauru, SP, Brasil. | en_US |
Affilliation | Cancer and Translational Medicine Research Unit. Faculty of Medicine and Medical Research Center. Oulu University Hospital. University of Oulu. Oulu, Finland. | en_US |
Affilliation | Department of Oral and Maxillofacial Diseases. Helsinki University Central Hospital and Translational Immunology Research Program. University of Helsinki. Helsinki, Finland. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil / Instituto D'Or de Pesquisa e Ensino. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil. | en_US |
Affilliation | Universidade Federal de Alfenas. Instituto de Ciências Biomédicas. m Departamento de Patologia e Parasitologia. Alfenas, MG, Brasil. | en_US |
Affilliation | Universidad de los Andes. Facultad de Odontología, and Centro de Investigación e Innovación Biomédica. Santiago, Chile. | en_US |
Affilliation | Lady Davis Institute for Medical Research and Segal Cancer Center. Jewish General Hospital. Department of Otolaryngology-Head and Neck Surgery. McGill University. Montreal, QC, Canada. | en_US |
Affilliation | Departamento de Patologia Oral e Medicina Oral. Escola dental. Universidade Estadual do Oeste do Paraná. Cascavel, PR, Brasil. | en_US |
Affilliation | Universidade de Campinas. Faculdade de Odontologia de Piracicaba. Departamento de Biociências. Programa de Pós-Graduação em Biologia Oral. Piracicaba, SP, Brasil. | en_US |
Affilliation | Universidade Estadual Paulista. Faculdade de Odontologia de Araraquara. Departamento de Diagnóstico e Cirurgia. Araraquara, SP, Brasil. | en_US |
Affilliation | Cancer and Translational Medicine Research Unit. Faculty of Medicine and Medical Research Center. Oulu University Hospital. University of Oulu. Oulu, Finland / Department of Oral and Maxillofacial Diseases. Helsinki University Central Hospital and Translational Immunology Research Program. University of Helsinki. Helsinki, Finland / HUSLAB. Department of Pathology. Helsinki University Central Hospital. University of Helsinki. Helsinki, Finland. | en_US |
Affilliation | Universidade de Campinas. Faculdade de Odontologia de Piracicaba. Departamento de Diagnóstico Oral. Programa de Pós-Graduação em Biologia Oral. Piracicaba, SP, Brasil. | en_US |
Subject | MIR-218-5p | en_US |
Subject | STIP1 | en_US |
Subject | Invasion | en_US |
Subject | Oral cancer | en_US |
Subject | Prognosis | en_US |
Subject | Proliferation | en_US |
DeCS | Neoplasias bucais | en_US |
DeCS | Prognóstico | en_US |