Author | Thornhill, Joyce | |
Author | Kusel, John Robert | |
Author | Oliviera, Fabricia Alvisi de | |
Author | Ribeiro, Fabio | |
Author | Lima, Symone Fulgêncio | |
Author | Coelho, Paulo Marcos Zach | |
Author | McVeigh, Paul | |
Author | Mattos, Ana Carolina Alves de | |
Access date | 2012-11-28T14:40:01Z | |
Available date | 2012-11-28T14:40:01Z | |
Document date | 2010 | |
Citation | THORNHILL, Joyce et al. Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni). Mem Inst Oswaldo Cruz, Rio de Janeiro, Vol. 105(4): 387-390, July 2010 | pt_BR |
ISSN | 0074-0276 | |
URI | https://www.arca.fiocruz.br/handle/icict/5896 | |
Language | eng | pt_BR |
Rights | open access | pt_BR |
Title | Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni) | pt_BR |
Type | Article | pt_BR |
Abstract | Here, we observed the uptake of membrane-impermeant molecules by cercariae as they penetrate the skin and are transformed into schistosomula. We propose that membrane-impermeant molecules, Lucifer yellow, Propidium iodide and Hoechst 33258 enter the parasite through both thenephridiopore and the surface membrane and then diffuse throughout the body of the parasite. We present a hypothesis that the internal cells of the body of the schisto-somulum represent a new host-parasite interface, at which skin-derived growth factors may stimulate receptors on internal membranes during transformation of the cercariae into the schistosomulum | pt_BR |
Affilliation | University of Glasgow. Glasgow, Scotland. UK | pt_BR |
Affilliation | University of Glasgow. Glasgow, Scotland. UK | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Queen’s University Belfast. Belfast, Northern Ireland, UK | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil | pt_BR |
Subject | Schistosoma mansoni | pt_BR |
Subject | membrane impermeant Lucifer yellow | pt_BR |
Subject | nephridiopore | pt_BR |
Subject | host/parasite interface | pt_BR |
Subject | linoleic acid | pt_BR |