Author | Marin, Anelis Maria | |
Author | Sanchuki, Heloisa Bruna Soligo | |
Author | Namur, Guilherme Naccache | |
Author | Uno, Miyuki | |
Author | Zanette, Dalila Lucíola | |
Author | Aoki, Mateus Nóbrega | |
Access date | 2023-05-17T11:49:43Z | |
Available date | 2023-05-17T11:49:43Z | |
Document date | 2023 | |
Citation | MARIN, Anelis Maria et al. Circulating cell-free nucleic acids as biomarkers for diagnosis and prognosis of pancreatic cancer. Biomedicines, v. 11, n. 10-169, p. 1-25, 2023. | en_US |
ISSN | 2227-9059 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/58451 | |
Language | por | en_US |
Publisher | MDPI | en_US |
Rights | open access | en_US |
Subject in Portuguese | Câncer Pancreático | en_US |
Title | Circulating cell-free nucleic acids as biomarkers for diagnosis and prognosis of pancreatic cancer | en_US |
Type | Article | en_US |
DOI | https://doi.org/10.3390/biomedicines11041069 | |
Abstract | A lack of reliable early diagnostic tools represents a major challenge in the management of pancreatic cancer (PCa), as the disease is often only identified after it reaches an advanced stage. This highlights the urgent need to identify biomarkers that can be used for the early detection, staging, treatment monitoring, and prognosis of PCa. A novel approach called liquid biopsy has emerged in recent years, which is a less- or non-invasive procedure since it focuses on plasmatic biomarkers such as DNA and RNA. In the blood of patients with cancer, circulating tumor cells (CTCs) and cell-free nucleic acids (cfNAs) have been identified such as DNA, mRNA, and non-coding RNA (miRNA and lncRNA). The presence of these molecules encouraged researchers to investigate their potential as biomarkers. In this article, we focused on circulating cfNAs as plasmatic biomarkers of PCa and analyzed their advantages compared to traditional biopsy methods. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil. | en_US |
Affilliation | Faculdade de Medicina da Universidade de São Paulo. Departamento de Radiologia e Oncologia. Centro de Investigação Translacional em Oncologia. São Paulo, SP, Brasil / Faculdade de Medicina da São Paulo. Hospital das Clínicas. São Paulo, SP, Brasil / Instituto do Câncer do Estado de São Paulo. São Paulo, SP, Brasil. | en_US |
Affilliation | Faculdade de Medicina da Universidade de São Paulo. Departamento de Radiologia e Oncologia. Centro de Investigação Translacional em Oncologia. São Paulo, SP, Brasil / Faculdade de Medicina da São Paulo. Hospital das Clínicas. São Paulo, SP, Brasil / Instituto do Câncer do Estado de São Paulo. São Paulo, SP, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil. | en_US |
Subject | Pancreatic Neoplasms | en_US |
Subject | Cell-Free Nucleic Acids | en_US |
Subject | Early Diagnosis | en_US |
Subject | Prognosis | en_US |
Subject in Spanish | Neoplasias Pancreáticas | en_US |
Subject in Spanish | Ácidos Nucleicos Libres de Células | en_US |
Subject in Spanish | Diagnóstico Precoz | en_US |
Subject in Spanish | Pronóstico | en_US |
Subject in French | Tumeurs du pancréas | en_US |
Subject in French | Acides nucléiques acellulaires | en_US |
Subject in French | Diagnostic précoce | en_US |
Subject in French | Pronostic | en_US |
DeCS | Neoplasias Pancreáticas | en_US |
DeCS | Ácidos Nucleicos Livres | en_US |
DeCS | Diagnóstico Precoce | en_US |
DeCS | Prognóstico | en_US |