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https://www.arca.fiocruz.br/handle/icict/58347
ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS INDUCED BY ITRACONAZOLE: AN IMMUNOLOGICAL APPROACH
Author
Affilliation
Laboratory of Cellular and Molecular Immunology. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil
Laboratory of Cellular and Molecular Immunology. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil
Laboratory of Cellular and Molecular Immunology. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil
Laboratory of Cellular and Molecular Immunology. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil
Laboratory of Cellular and Molecular Immunology. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil/Clinical Immunology Laboratory. George Washington University. Washington, DC, USA
Laboratory of Cellular and Molecular Immunology. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil
Laboratory of Cellular and Molecular Immunology. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil
Laboratory of Cellular and Molecular Immunology. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil
Laboratory of Cellular and Molecular Immunology. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil/Clinical Immunology Laboratory. George Washington University. Washington, DC, USA
Abstract
Acute generalized exanthematous pustulosis (AGEP) is an uncommon disease, which presents as a nonfollicular erythematous sterile pustular eruption. More than 90% of the cases are induced by adverse drug reactions, often triggered by anti-infectious systemic drugs. We report a case of itraconazole-induced AGEP in a 22-year-old man, with an assessment of his cytokine/chemokine production and drug-specific cell reactivity. We found that AGEP, like other T cell-mediated drug eruptions, alters the immunological status of the patient, probably favouring T-cell activation, recruitment and regulation. Few cases of itraconazole-induced AGEP have been described in the literature, and to our knowledge, this is the first report in which the cellular immunological features are assessed
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