Author | Rezende, Izabela Mauricio de | |
Author | McClure, Max A. | |
Author | Pereira, Leonardo S. | |
Author | Fradico, Jordana Rodrigues Barbosa | |
Author | Cenachi, Adriana R. C. | |
Author | Moura, Alexandre S. | |
Author | Paladino, Luísa L. de A. | |
Author | Dutra, Maria Rita T. | |
Author | Alves, Pedro Augusto | |
Author | Xavier, Marcelo Antônio Pascoal | |
Author | Said, Rodrigo F. do C. | |
Author | Ramalho, Dario B. | |
Author | Gama, Thaysa D. P. | |
Author | Martins Filho, Olindo Assis | |
Author | Monath, Thomas P. | |
Author | Carvalho, Andréa Teixeira de | |
Author | Drumond, Betânia Paiva | |
Author | LaBeaud, Angelle D. | |
Access date | 2023-05-11T13:58:57Z | |
Available date | 2023-05-11T13:58:57Z | |
Document date | 2023 | |
Citation | REZENDE, Izabela Mauricio de et al. Characterization and investigation of risk factors for Late-relapsing hepatitis after yellow fever. Clin. infect. Dis., ciad249, 2023. doi: 10.1093/cid/ciad249. | en_US |
ISSN | 1058-4838 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/58315 | |
Description | Yellow Fever Collaborative Group: Alexandre Maurício Castro Bragato, Argus Leão Araújo, Flávio Augusto de Almeida Faria, Indiara Penido, Letícia Menezes, Livia Frota Rabelo, Livia Pamplona, Lívia Fulgêncio da Cunha Melo, Lívia Soares Coelho Fonte Boa, Lívia Zignago Moreira Dos Santos, Ludmila de Paula, Marcelle Cardoso Marçal, Natalia Soares Albuquerque, Rodrigo Macedo, Tayrine Araújo | en_US |
Language | eng | en_US |
Publisher | Oxford University Press | en_US |
Rights | restricted access | en_US |
Title | Characterization and investigation of risk factors for Late-relapsing hepatitis after yellow fever | en_US |
Type | Article | en_US |
Abstract | Background: Late relapsing hepatitis after yellow fever (LHep-YF) during the convalescent phase of the disease has been described during recent yellow fever (YF) outbreaks in Brazil. LHep-YF is marked by the rebound in liver enzymes and non-specific clinical manifestations around 30-60 days after YF symptom onset.
Methods: Here we have characterized the clinical course and risk factors for LHep-YF using data from a representative cohort of patients who survived YF in Brazil, 2017-2018. A total of 221 YF-positive patients were discharged from the infectious disease reference hospital in Minas Gerais, and were followed-up at 30-, 45- and 60- days post symptom onset (dps).
Results: From 46 up to 60 dps, 16% of YF patients (n=36/221) exhibited a rebound of transaminases (AST or ALT >500 IU/L), alkaline phosphatase, and total bilirubin levels. Other etiologies of liver inflammation such as infectious hepatitis, autoimmune hepatitis, and metabolic liver disease were ruled out. Jaundice, fatigue, headache, and low platelet levels were associated with LHep-YF. Demographic factors, clinical manifestations, laboratory tests, ultrasound findings, and viral load during the acute phase of YF were not associated with the occurrence of LHep-YF.
Conclusions: These findings provide new data on the clinical course of late relapsing hepatitis during the convalescent phase of YF and highlight the need for extended patient follow-up after acute YF. | en_US |
Affilliation | Federal University of Minas Gerais. Laboratory of Viruses. Microbiology Department. Belo Horizonte, MG, Brasil / Stanford University School of Medicine. Department of Pediatrics. Division of Infectious Diseases. Stanford, CA, USA. | en_US |
Affilliation | University School of Medicine. Department of Pediatrics. Division of Infectious Diseases. Stanford, CA, USA. | en_US |
Affilliation | Hospital Eduardo de Menezes. Estado de Minas Gerais. Fundação Hospitalar de Minas Gerais. Belo Horizonte, MG, Brasil. | en_US |
Affilliation | Oswaldo Cruz Foundation. René Rachou Institute. Integrated Group of Biomarkers Research. Belo Horizonte, MG, Brazil. | en_US |
Affilliation | Fundação Hospitalar de Minas Gerais. Hospital Eduardo de Menezes. Belo Horizonte, MG, Brasil | en_US |
Affilliation | Fundação Hospitalar de Minas Gerais. Hospital Eduardo de Menezes. Belo Horizonte, MG, Brasil | en_US |
Affilliation | Fundação Hospitalar de Minas Gerais. Hospital Eduardo de Menezes. Belo Horizonte, MG, Brasil | en_US |
Affilliation | Fundação Hospitalar de Minas Gerais. Hospital Eduardo de Menezes. Belo Horizonte, MG, Brasil | en_US |
Affilliation | Oswaldo Cruz Foundation. René Rachou Institute. Immunology of Viruses Diseases. Belo Horizonte, MG, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. René Rachou Institute. Immunology of Viruses Diseases. Belo Horizonte, MG, Brazil. | en_US |
Affilliation | Estado de Minas Gerais. Secretaria de Estado de Minas Gerais. Belo Horizonte, MG, Brazil. | en_US |
Affilliation | Fundação Hospitalar de Minas Gerais. Hospital Eduardo de Menezes. Belo Horizonte, MG, Brasil | en_US |
Affilliation | Fundação Hospitalar de Minas Gerais. Hospital Eduardo de Menezes. Belo Horizonte, MG, Brasil | en_US |
Affilliation | Oswaldo Cruz Foundation. René Rachou Institute. Integrated Group of Biomarkers Research. Belo Horizonte, MG, Brazil. | en_US |
Affilliation | Crozet BioPharma LLC. Lexington MA, USA. | en_US |
Affilliation | Oswaldo Cruz Foundation. René Rachou Institute. Integrated Group of Biomarkers Research. Belo Horizonte, MG, Brazil. | en_US |
Affilliation | Federal University of Minas Gerais. Microbiology Department. Laboratory of Viruses. Belo Horizonte, MG, Brasil. | en_US |
Affilliation | University School of Medicine. Division of Infectious Diseases. Department of Pediatrics. Stanford Stanford, CA, USA. | en_US |
Subject | Yellow fever | en_US |
Subject | convalescent phase | en_US |
Subject | hepatitis | en_US |
Subject | relapsing hepatitis | en_US |
Subject | virus persistence | en_US |
Subject | yellow fever virus | en_US |
Embargo date | 2099-12-31 | |