Author | Oliveira, Viviane Sampaio Boaventura de | |
Author | Santos, Claire da Silva | |
Author | Cardoso, Cristina Ribeiro de Barros | |
Author | Andrade, José de | |
Author | dosSantos, Washington Luis Conrado | |
Author | Clarêncio, Jorge | |
Author | Silva, João Santana da | |
Author | Borges, Valeria de Matos | |
Author | Barral Netto, Manoel | |
Author | Brodskyn, Claudia Ida | |
Author | Barral, Aldina Maria Prado | |
Access date | 2012-11-14T20:29:20Z | |
Available date | 2012-11-14T20:29:20Z | |
Document date | 2010 | |
Citation | BOAVENTURA, V. S. et al. Human mucosal leishmaniasis: neutrophils infiltrate areas of tissue damage that express high levels of Th17-related cytokines. European Journal of Immunology, v. 40, n. 10, p. 2830-2836, out. 2010. | pt_BR |
ISSN | 0014-2980 | |
URI | https://www.arca.fiocruz.br/handle/icict/5815 | |
Language | eng | pt_BR |
Rights | open access | |
Title | Human mucosal leishmaniasis: neutrophils infiltrate areas of tissue damage that express high levels of Th17-related cytokines | pt_BR |
Type | Article | pt_BR |
DOI | 10.1002/eji.200940115 | |
Abstract | Mucosal leishmaniasis (ML) is characterised by severe tissue destruction. Herein, we evaluated the involvement of the IL-17-type response in the inflammatory infiltrate of biopsy specimens from 17 ML patients. IL-17 and IL-17-inducing cytokines (IL-1ß, IL-23, IL-6 and TGF-ß) were detected by immunohistochemistry in ML patients. IL-17(+) cells exhibited CD4(+), CD8(+) or CD14(+) phenotypes, and numerous IL-17(+) cells co-expressed the CC chemokine receptor 6 (CCR6). Neutrophils, a hallmark of Th17-mediated inflammation, were regularly detected in necrotic and perinecrotic areas and stained positive for neutrophil elastase, myeloperoxidase and MMP-9. Taken together, these observations demonstrate the existence of Th17 cells in ML lesions associated with neutrophils in areas of tissue injury and suggest that IL-17 is involved in ML pathogenesis | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal do Triângulo Mineiro.Departamento de Ciências Biológicas. Minas Gerais, BH, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto, SP, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Subject | Human | pt_BR |
Subject | Mucosal leishmaniasis | pt_BR |
Subject | Neutrophils | pt_BR |
Subject | Th17 | pt_BR |
DeCS | Interleucina-17/Imunologia | pt_BR |
DeCS | Leishmania/Imunologia | pt_BR |
DeCS | Leishmaniose Mucocutânea/Imunologia | pt_BR |
DeCS | Neutrófilos/Imunologia | pt_BR |