Author | Veras Gonçalves, Andréia | |
Author | Miranda-Filho, Demócrito de B. | |
Author | Rocha Vilela, Líbia Cristina | |
Author | Ramos, Regina Coeli Ferreira | |
Author | de Araújo, Thalia V. B. | |
Author | de Vasconcelos, Rômulo A. L. | |
Author | Wanderley Rocha, Maria Angela | |
Author | Eickmann, Sophie Helena | |
Author | Cordeiro, Marli Tenório | |
Author | Ventura, Liana O. | |
Author | Montarroyos, Ulisses Ramos | |
Author | Mertens Brainer, Alessandra | |
Author | Costa Gomes, Maria Durce | |
Author | da Silva, Paula Fabiana Sobral | |
Author | Martelli, Celina M. T. | |
Author | Brickley, Elizabeth B. | |
Author | Ximenes, Ricardo A. A. | |
Access date | 2023-04-27T13:43:56Z | |
Available date | 2023-04-27T13:43:56Z | |
Document date | 2020-12-22 | |
Citation | GONÇALVES, Andréia Veras; MIRANDA-FILHO, Demócrito de B.; VILELA, Líbia Cristina Rocha; RAMOS, Regina Coeli Ferreira; ARAðJO, Thalia V. B. de; VASCONCELOS, Rômulo A. L. de; ROCHA, Maria Angela Wanderley; EICKMANN, Sophie Helena; CORDEIRO, Marli Tenório; VENTURA, Liana O. et al. Endocrine Dysfunction in Children with Zika-Related Microcephaly Who Were Born during the 2015 Epidemic in the State of Pernambuco, Brazil. Viruses, [S.L.], v. 13, n. 1, p. 1-13, 22 dez. 2020. MDPI AG. http://dx.doi.org/10.3390/v13010001. | en_US |
ISSN | 1999-4915 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/58030 | |
Language | por | en_US |
Rights | open access | en_US |
Title | Endocrine Dysfunction in Children with Zika-Related Microcephaly Who Were Born during the 2015 Epidemic in the State of Pernambuco, Brazil | en_US |
Type | Article | en_US |
Abstract | Congenital viral infections and the occurrence of septo-optic dysplasia, which is a combination of optic nerve hypoplasia, abnormal formation of structures along the midline of the brain, and pituitary hypofunction, support the biological plausibility of endocrine dysfunction in Zika-related microcephaly. In this case series we ascertained the presence and describe endocrine dysfunction in 30 children with severe Zika-related microcephaly from the MERG Pediatric Cohort, referred for endocrinological evaluation between February and August 2019. Of the 30 children, 97% had severe microcephaly. The average age at the endocrinological consultation was 41 months and 53% were female. The most frequently observed endocrine dysfunctions comprised short stature, hypothyroidism, obesity and variants early puberty. These dysfunctions occurred alone 57% or in combination 43%. We found optic nerve hypoplasia (6/21) and corpus callosum hypoplasia (20/21). Seizure crises were reported in 86% of the children. The most common—and clinically important—endocrine dysfunctions were pubertal dysfunctions, thyroid disease, growth impairment, and obesity. These dysfunctions require careful monitoring and signal the need for endocrinological evaluation in children with Zika-related microcephaly, in order to make early diagnoses and implement appropriate treatment when necessary. | en_US |
Affilliation | Fundação Oswaldo Cruz, Instituto Aggeu Magalhães, Recife, PE, Brasil.
Universidade Federal de Pernambuco, Departamento de Medicina Tropical, Centro de Ciências da Saúde, Recife, PE Brasil.
Hospital Universitário Oswaldo Cruz, Unidade de Endocrinologia, Recife, PE, Brasil.
Universidade de Pernambuco, Pós-Graduação em Ciências da Saúde, Recife, PE, Brasil.
Hospital Universitário Oswaldo Cruz, Departamento de Infectologia Pediátrica, Recife, PE, Brasil.
Universidade Federal de Pernambuco, Departamento de Medicina Social, Recife, PE, Brasil.
Universidade Federal de Pernambuco, Centro de Ciências da Saúde, Departamento Materno-Infantil, Recife, PE, Brasil.
Fundação Altino Ventura, Departamento de Oftalmologia, Recife, PE, Brasil.
Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.
Universidade de Pernambuco, Departamento de Medicina Interna, Recife, PE, Brasil. | |
Subject | microcephal | en_US |
Subject | Zika | en_US |
Subject | obesit | en_US |
Subject | hypothyroidism | en_US |
Subject | puberty | en_US |