Author | Nascimento, Camila | |
Author | Castro, Flávia | |
Author | Domingues, Mariana | |
Author | Lage, Anna | |
Author | Alves, Érica | |
Author | Oliveira, Rodrigo Correa de | |
Author | Melo, Celso de | |
Author | Silva, Carlos Eduardo Calzavara | |
Author | Sarmento, Bruno | |
Access date | 2023-04-24T17:21:01Z | |
Available date | 2023-04-24T17:21:01Z | |
Document date | 2023 | |
Citation | NASCIMENTO, Camila et al. Reprogramming of tumor-associated macrophages by polyaniline-coated iron oxide nanoparticles applied to treatment of breast cancer. International Journal of Pharmaceutics, v. 636, p. 1-15, 2023. | en_US |
ISSN | 0378-5173 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/57941 | |
Language | eng | en_US |
Publisher | Elsevier | en_US |
Rights | restricted access | en_US |
Title | Reprogramming of tumor-associated macrophages by polyaniline-coated iron oxide nanoparticles applied to treatment of breast câncer | en_US |
Type | Article | en_US |
DOI | 10.1016/j.ijpharm.2023.122866 | |
Abstract | Breast cancer is the most commonly diagnosed type of cancer among the female population worldwide. It is a disease with a high incidence and geographic distribution that negatively impacts global public health and deleteriously affect the quality of life of cancer patients. Among the new approaches, cancer immunotherapy is the most promising trend in oncology by stimulating the host's own immune system to efficiently destroy cancer cells. Recent evidence has indicated that iron oxide nanoparticles can promote the reprograming of M2 into M1 macrophages with anti-tumor effects in the tumor microenvironment. Thus, the aim of the present work was to evaluate the ability of polyaniline-coated maghemite (Pani/γ-Fe2O3) nanoparticles to modulate human macrophages in 2D monolayers and 3D multicellular breast cancer models. It was observed that Pani/γ-Fe2O3 NPs re-educated IL-10-stimulated macrophages towards a pro-inflammatory profile, decreasing the proportion of CD163+ and increasing the CD86+ proportion in 2D models. NPs were successfully taken-up by macrophages presented in the 3D model and were also able to induce an increasing in their CD86+ proportion in triple MCTs model. Overall, our findings open new perspectives on the use of Pani/γ-Fe2O3 NPs as an immunomodulatory therapy for macrophage reprogramming towards an anti-tumor M1 phenotype, providing a new tool for breast cancer immunotherapies. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisa em Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil. | en_US |
Affilliation | Universidade do Porto. Instituto Nacional de Engenharia Biomédica. Porto, Portugal / Universidade do Porto. Instituto de Investigação e Inovação em Saúde. Porto, Portugal. | en_US |
Affilliation | Universidade do Porto. Instituto Nacional de Engenharia Biomédica. Porto, Portugal / Universidade do Porto. Instituto de Investigação e Inovação em Saúde. Porto, Portugal / Faculdade de Engenharia da Universidade do Porto. Porto, Portugal. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisa em Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisa em Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisa em Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil. | en_US |
Affilliation | Universidade Federal de Pernambuco. Departamento de Física. Grupo de Polímeros Não-Convencionais. Recife, PE, Brazil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisa em Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil. | en_US |
Affilliation | Universidade do Porto. Instituto Nacional de Engenharia Biomédica. Porto, Portugal/Universidade do Porto. Instituto de Investigação e Inovação em Saúde. Porto, Portugal / CESPU – IUCS. Gandra, Portugal. | en_US |
Embargo date | 2099-12-31 | |