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https://www.arca.fiocruz.br/handle/icict/57889
GENETICS OF LATIN AMERICAN DIVERSITY (GLAD) PROJECT: INSIGHTS INTO POPULATION GENETICS AND ASSOCIATION STUDIES IN RECENTLY ADMIXED GROUPS IN THE AMERICAS
Author
Borda, Victor
Loesch, Douglas P.
Guo, Bing
Laboulaye, Roland
Veliz-Otani, Diego
FrenchKwawu, Jennifer N.
Leal, Thiago Peixoto
Gogarten, Stephanie M.
Ikpe, Sunday
Gouveia, Mateus H.
Mendes, Marla
Abecasis, Gonçalo R.
Alvim, Isabela
Arboleda-Bustos, Carlos E.
Arboleda, Gonzalo
Arboleda, Humberto
Barreto, Mauricio L.
Barwick, Lucas
Bezzera, Marcos A.
Blangero, John
Borges, Vanderci
Caceres, Omar
Cai, Jianwen
Chana-Cuevas, Pedro
Chen, Zhanghua
Custer, Brian
Dean, Michael
Dinardo, Carla
Domingos, Igor
Duggirala, Ravindranath
Dieguez, Elena
Fernandez, Willian
Ferraz, Henrique B.
Gilliland, Frank
Guio, Heinner
Horta, Bernardo
Curran, Joanne E.
Johnsen, Jill M.
Kaplan, Robert C.
Kelly, Shannon
Kenny, Eimear E.
Kittner, Stephen
Konkle, Barbara A.
Kooperberg, Charles
Lescano, Andres
Costa, Maria Fernanda Furtado Lima
Loos, Ruth J. F.
Manichaikul, Ani
Meyers, Deborah A.
Mitchell, Braxton D.
Naslavsky, Michel S.
Nickerson, Deborah A.
North, Kari E.
Padilla, Carlos
Preuss, Michael
Raggio, Victor
Reiner, Alexander P.
Rich, Stephen S.
Rieder, Carlos R.
Rienstra, Michiel
Rotter, Jerome I.
Rundek, Tatjana
Sacco, Ralph L.
Sanchez, Cesar
Santos-Lobato, Bruno Lopes
Schumacher-Schuh, Artur Francisco
Scliar, Marilia O.
Silverman, Edwin K.
Sofer, Tamar
Lasky-Su, Jessica
Tumas, Vitor
Weiss, Scott T.
Diversos autores
Mata, Ignacio F.
Hernandez, Ryan D.
Santos, Eduardo Tarazona
O’Connor, Timothy D.
Loesch, Douglas P.
Guo, Bing
Laboulaye, Roland
Veliz-Otani, Diego
FrenchKwawu, Jennifer N.
Leal, Thiago Peixoto
Gogarten, Stephanie M.
Ikpe, Sunday
Gouveia, Mateus H.
Mendes, Marla
Abecasis, Gonçalo R.
Alvim, Isabela
Arboleda-Bustos, Carlos E.
Arboleda, Gonzalo
Arboleda, Humberto
Barreto, Mauricio L.
Barwick, Lucas
Bezzera, Marcos A.
Blangero, John
Borges, Vanderci
Caceres, Omar
Cai, Jianwen
Chana-Cuevas, Pedro
Chen, Zhanghua
Custer, Brian
Dean, Michael
Dinardo, Carla
Domingos, Igor
Duggirala, Ravindranath
Dieguez, Elena
Fernandez, Willian
Ferraz, Henrique B.
Gilliland, Frank
Guio, Heinner
Horta, Bernardo
Curran, Joanne E.
Johnsen, Jill M.
Kaplan, Robert C.
Kelly, Shannon
Kenny, Eimear E.
Kittner, Stephen
Konkle, Barbara A.
Kooperberg, Charles
Lescano, Andres
Costa, Maria Fernanda Furtado Lima
Loos, Ruth J. F.
Manichaikul, Ani
Meyers, Deborah A.
Mitchell, Braxton D.
Naslavsky, Michel S.
Nickerson, Deborah A.
North, Kari E.
Padilla, Carlos
Preuss, Michael
Raggio, Victor
Reiner, Alexander P.
Rich, Stephen S.
Rieder, Carlos R.
Rienstra, Michiel
Rotter, Jerome I.
Rundek, Tatjana
Sacco, Ralph L.
Sanchez, Cesar
Santos-Lobato, Bruno Lopes
Schumacher-Schuh, Artur Francisco
Scliar, Marilia O.
Silverman, Edwin K.
Sofer, Tamar
Lasky-Su, Jessica
Tumas, Vitor
Weiss, Scott T.
Diversos autores
Mata, Ignacio F.
Hernandez, Ryan D.
Santos, Eduardo Tarazona
O’Connor, Timothy D.
Affilliation
Institute for Genome Sciences. University of Maryland School of Medicine. Baltimore, MD, USA.
Institute for Genome Sciences. University of Maryland School of Medicine. Baltimore, MD, USA.
Institute for Genome Sciences. University of Maryland School of Medicine. Baltimore, MD, USA.
Institute for Genome Sciences. University of Maryland School of Medicine. Baltimore, MD, USA.
Institute for Genome Sciences. University of Maryland School of Medicine. Baltimore, MD, USA.
Institute for Genome Sciences. University of Maryland School of Medicine. Baltimore, MD, USA.
Lerner Research Institute, Genomic Medicine. Cleveland Clinic. Cleveland, OH, USA.
Department of Biostatistics. University of Washington. Seattle, WA, USA.
Institute for Genome Sciences. University of Maryland School of Medicine. Baltimore, MD, USA.
Center for Research on Genomics and Global Health. National Human Genome Research Institute. National Institutes of Health. Bethesda, MD, USA.
Department of Genetics, Ecology, and Evolution. Instituto de Ciências Biológicas. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil.
Department of Biostatistics. University of Michigan School of Public Health. Ann Arbor, MI, USA.
Department of Genetics, Ecology, and Evolution. Instituto de Ciências Biológicas. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil.
Neuroscience and Cell Death Research Groups. Medical School and Genetic Institute. Universidad Nacional de Colombia. Bogota, Colombia.
Neuroscience and Cell Death Research Groups. Medical School and Genetic Institute. Universidad Nacional de Colombia. Bogota, Colombia.
Neuroscience and Cell Death Research Groups. Medical School and Genetic Institute. Universidad Nacional de Colombia. Bogota, Colombia.
Instituto de Saúde Coletiva. Universidade Federal da Bahia. Salvador, BA, Brazil.
LTRC Data Coordinating Center.The Emmes Company. LLC. Rockville, MD, USA.
Department of Genetics. Federal University of Pernambuco. Recife, PE, Brazil.
Department of Human Genetics and South Texas Diabetes and Obesity Institute. University of Texas. Rio Grande Valley School of Medicine. Brownsville TX, USA.
Movement Disorders Unit. Department of Neurology and Neurosurgery. Universidade Federal de São Paulo. São Paulo, SP, Brazil.
Instituto Nacional de Salud. Lima, Perú/ Facultad de Ciencias de la Salud. Universidad Científica del Sur. Lima, Perú.
Department of Biostatistics. University of North Carolina. Chapel Hill, USA
CETRAM, Facultad de Ciencias Médicas. Universidad de Santiago de Chile. Santiago, Chile.
Keck School of Medicine. University of Southern California. Los Angeles, CA, USA.
Vitalant Research Institute. San Francisco, CA, USA
Laboratory of Genomic Diversity. Division of Cancer Epidemiology and Genetics. NCI, NIH. Rockville, MD, USA.
Instituto de Medicina Tropical. University of São Paulo. São Paulo, SP, Brazil.
Instituto de Medicina Tropical. University of São Paulo. São Paulo, SP, Brazil.
Department of Genetics. Federal University of Pernambuco. Recife, PE, Brazil.
Department of Human Genetics and South Texas Diabetes and Obesity Institute. University of Texas. Rio Grande Valley School of Medicine. Brownsville TX, USA
Neurology Institute. Universidad de la República. Montevideo, Uruguay.
Neuroscience and Cell Death Research Groups. Medical School and Genetic Institute. Universidad Nacional de Colombia. Bogota, Colombia.
Movement Disorders Unit. Department of Neurology and Neurosurgery. Universidade Federal de São Paulo. São Paulo, SP, Brazil.
Keck School of Medicine. University of Southern California. Los Angeles, CA, USA.
Instituto Nacional de Salud. Lima, Perú/ INBIOMEDIC Medicina Preventiva y Personalizada. Lima, Perú/Centro de Investigación en Medicina Traslacional. Universidad Privada Norbert Wiener. Lima, Perú.
Universidade Federal de Pelotas. Departamento de Medicina Social. Faculdade de Medicina. Pelotas, RS, Brazil.
Department of Human Genetics and South Texas Diabetes and Obesity Institute. University of Texas. Rio Grande Valley School of Medicine. Brownsville TX, USA.
Bloodworks Northwest Research Institute. Seattle, WA, USA
Department of Epidemiology and Population Health. Albert Einstein College of Medicine. Bronx, NY, USA/Division of Public Health Sciences. Fred Hutchinson Cancer Center. Seattle, WA, USA.
Vitalant Research Institute. San Francisco, CA, USA/ UCSF Benioff Children's Hospital Oakland.
Icahn School of Medicine at Mount Sinai. New York, NY, USA.
Department of Neurology. University of Maryland School of Medicine. Baltimore, MD, USA.
Department of Medicine. University of Washington. Seattle, WA, USA.
Division of Public Health Sciences. Fred Hutchinson Cancer Center. Seattle, WA, USA.
Neurology Institute. Universidad de la República. Montevideo, Uruguay.
Fundação Oswaldo Cruz. Instituto de Pesquisas René Rachou. Belo Horizonte, MG, Brazil.
The Charles Bronfman Institute for Personalized Medicine. Icahn School of Medicine at Mount Sinai. New York, NY, USA.
Center for Public Health Genomics. University of Virginia. Charlottesville, VA, USA.
Division of Genetics. Genomics, and Precision Medicine. University of Arizona. Tucson, AZ, USA.
Department of Medicine. University of Maryland School of Medicine. Baltimore, MD, USA/Geriatrics Research and Education Clinical Center. Baltimore Veterans Administration Medical Center. Baltimore, MD, USA.
Human Genome and Stem Cell Research Center. University of São Paulo. São Paulo, SP, Brazil.
Department of Genome Sciences. University of Washington. Seattle, WA, USA.
Department of Epidemiology. Gillings School of Global Public Health. The University of North Carolina at Chapel Hill. Chapel Hill, NC, USA.
Instituto Nacional de Salud. Lima, Perú.
Icahn School of Medicine at Mount Sinai. New York, NY, USA.
Genetics Department. Facultad de Medicina. Universidad de la República. Montevideo, Uruguay.
Division of Public Health Sciences. Fred Hutchinson Cancer Center. Seattle, WA, USA/Department of Epidemiology. University of Washington. Seattle, WA, USA.
Center for Public Health Genomics. University of Virginia. Charlottesville, VA, USA.
Universidade Federal de Ciências da Saúde de Porto Alegre. Departamento de Neurologia. Porto Alegre, RS, Brazil.
Department of Cardiology, University of Groningen. University Medical Center Groningen. Groningen, The Netherlands.
The Institute for Translational Genomics and Population Sciences. Department of Pediatrics. The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center. Torrance, CA USA.
Department of Neurology. Miller School of Medicine. University of Miami. FL, USA /The Evelyn F. McKnight Brain Institute. FL, USA.
Department of Neurology. Miller School of Medicine. University of Miami. FL, USA /The Evelyn F. McKnight Brain Institute. FL, USA.
Instituto Nacional de Salud. Lima, Perú.
Instituto de Ciências da Saúde. Universidade Federal do Pará. Belém, PA, Brazil.
Departamento de Farmacologia. Universidade Federal do Rio Grande do Sul. Porto Alegre, RS, Brazil/Serviço de Neurologia. Hospital de Clínicas de Porto Alegre. Porto Alegre, RS, Brazil.
Human Genome and Stem Cell Research Center. University of São Paulo. São Paulo, SP, Brazil.
Channing Division of Network Medicine. Department of Medicine. Brigham and Women’s Hospital. Boston, MA, USA.
Division of Sleep and Circadian Disorders. Brigham and Women’s Hospital. Harvard Medical School. Boston, MA USA.
Channing Division of Network Medicine. Department of Medicine. Brigham and Women’s Hospital. Boston, MA, USA.
Ribeirão Preto Medical School. Universidade de São Paulo. Ribeirão Preto, SP, Brazil.
Channing Division of Network Medicine. Department of Medicine. Brigham and Women’s Hospital. Boston, MA, USA.
Latin American Research Consortium on the Genetics of Parkinson's Disease (LARGE-PD), NINDS Stroke Genetics Network (SiGN) Consortium, TOPMed Population Genetics Working Group
Lerner Research Institute. Genomic Medicine. Cleveland Clinic. Cleveland, OH, USA.
Institute for Human Genetics. University of California. San Francisco, CA, USA/ Bakar Computational Health Sciences Institute. University of California. San Francisco, CA, USA/Quantitative Biosciences Institute. University of California. San Francisco, CA, USA/ Department of Bioengineering and Therapeutic Sciences. University of California San Franciso, CA, USA.
Department of Genetics, Ecology, and Evolution. Instituto de Ciências Biológicas. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil/ Facultad de Salud Pública y Administración. Universidad Peruana Cayetano Heredia. Lima, Peru.
Institute for Genome Sciences. University of Maryland School of Medicine. Baltimore, MD, USA/ Department of Medicine. University of Maryland School of Medicine. Baltimore, MD, USA./Program in Health Equity and Population Health. University of Maryland School of Medicine. Baltimore, MD, USA/Program in Personalized Genomic Medicine. University of Maryland. School of Medicine. Baltimore, MD, USA.
Institute for Genome Sciences. University of Maryland School of Medicine. Baltimore, MD, USA.
Institute for Genome Sciences. University of Maryland School of Medicine. Baltimore, MD, USA.
Institute for Genome Sciences. University of Maryland School of Medicine. Baltimore, MD, USA.
Institute for Genome Sciences. University of Maryland School of Medicine. Baltimore, MD, USA.
Institute for Genome Sciences. University of Maryland School of Medicine. Baltimore, MD, USA.
Lerner Research Institute, Genomic Medicine. Cleveland Clinic. Cleveland, OH, USA.
Department of Biostatistics. University of Washington. Seattle, WA, USA.
Institute for Genome Sciences. University of Maryland School of Medicine. Baltimore, MD, USA.
Center for Research on Genomics and Global Health. National Human Genome Research Institute. National Institutes of Health. Bethesda, MD, USA.
Department of Genetics, Ecology, and Evolution. Instituto de Ciências Biológicas. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil.
Department of Biostatistics. University of Michigan School of Public Health. Ann Arbor, MI, USA.
Department of Genetics, Ecology, and Evolution. Instituto de Ciências Biológicas. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil.
Neuroscience and Cell Death Research Groups. Medical School and Genetic Institute. Universidad Nacional de Colombia. Bogota, Colombia.
Neuroscience and Cell Death Research Groups. Medical School and Genetic Institute. Universidad Nacional de Colombia. Bogota, Colombia.
Neuroscience and Cell Death Research Groups. Medical School and Genetic Institute. Universidad Nacional de Colombia. Bogota, Colombia.
Instituto de Saúde Coletiva. Universidade Federal da Bahia. Salvador, BA, Brazil.
LTRC Data Coordinating Center.The Emmes Company. LLC. Rockville, MD, USA.
Department of Genetics. Federal University of Pernambuco. Recife, PE, Brazil.
Department of Human Genetics and South Texas Diabetes and Obesity Institute. University of Texas. Rio Grande Valley School of Medicine. Brownsville TX, USA.
Movement Disorders Unit. Department of Neurology and Neurosurgery. Universidade Federal de São Paulo. São Paulo, SP, Brazil.
Instituto Nacional de Salud. Lima, Perú/ Facultad de Ciencias de la Salud. Universidad Científica del Sur. Lima, Perú.
Department of Biostatistics. University of North Carolina. Chapel Hill, USA
CETRAM, Facultad de Ciencias Médicas. Universidad de Santiago de Chile. Santiago, Chile.
Keck School of Medicine. University of Southern California. Los Angeles, CA, USA.
Vitalant Research Institute. San Francisco, CA, USA
Laboratory of Genomic Diversity. Division of Cancer Epidemiology and Genetics. NCI, NIH. Rockville, MD, USA.
Instituto de Medicina Tropical. University of São Paulo. São Paulo, SP, Brazil.
Instituto de Medicina Tropical. University of São Paulo. São Paulo, SP, Brazil.
Department of Genetics. Federal University of Pernambuco. Recife, PE, Brazil.
Department of Human Genetics and South Texas Diabetes and Obesity Institute. University of Texas. Rio Grande Valley School of Medicine. Brownsville TX, USA
Neurology Institute. Universidad de la República. Montevideo, Uruguay.
Neuroscience and Cell Death Research Groups. Medical School and Genetic Institute. Universidad Nacional de Colombia. Bogota, Colombia.
Movement Disorders Unit. Department of Neurology and Neurosurgery. Universidade Federal de São Paulo. São Paulo, SP, Brazil.
Keck School of Medicine. University of Southern California. Los Angeles, CA, USA.
Instituto Nacional de Salud. Lima, Perú/ INBIOMEDIC Medicina Preventiva y Personalizada. Lima, Perú/Centro de Investigación en Medicina Traslacional. Universidad Privada Norbert Wiener. Lima, Perú.
Universidade Federal de Pelotas. Departamento de Medicina Social. Faculdade de Medicina. Pelotas, RS, Brazil.
Department of Human Genetics and South Texas Diabetes and Obesity Institute. University of Texas. Rio Grande Valley School of Medicine. Brownsville TX, USA.
Bloodworks Northwest Research Institute. Seattle, WA, USA
Department of Epidemiology and Population Health. Albert Einstein College of Medicine. Bronx, NY, USA/Division of Public Health Sciences. Fred Hutchinson Cancer Center. Seattle, WA, USA.
Vitalant Research Institute. San Francisco, CA, USA/ UCSF Benioff Children's Hospital Oakland.
Icahn School of Medicine at Mount Sinai. New York, NY, USA.
Department of Neurology. University of Maryland School of Medicine. Baltimore, MD, USA.
Department of Medicine. University of Washington. Seattle, WA, USA.
Division of Public Health Sciences. Fred Hutchinson Cancer Center. Seattle, WA, USA.
Neurology Institute. Universidad de la República. Montevideo, Uruguay.
Fundação Oswaldo Cruz. Instituto de Pesquisas René Rachou. Belo Horizonte, MG, Brazil.
The Charles Bronfman Institute for Personalized Medicine. Icahn School of Medicine at Mount Sinai. New York, NY, USA.
Center for Public Health Genomics. University of Virginia. Charlottesville, VA, USA.
Division of Genetics. Genomics, and Precision Medicine. University of Arizona. Tucson, AZ, USA.
Department of Medicine. University of Maryland School of Medicine. Baltimore, MD, USA/Geriatrics Research and Education Clinical Center. Baltimore Veterans Administration Medical Center. Baltimore, MD, USA.
Human Genome and Stem Cell Research Center. University of São Paulo. São Paulo, SP, Brazil.
Department of Genome Sciences. University of Washington. Seattle, WA, USA.
Department of Epidemiology. Gillings School of Global Public Health. The University of North Carolina at Chapel Hill. Chapel Hill, NC, USA.
Instituto Nacional de Salud. Lima, Perú.
Icahn School of Medicine at Mount Sinai. New York, NY, USA.
Genetics Department. Facultad de Medicina. Universidad de la República. Montevideo, Uruguay.
Division of Public Health Sciences. Fred Hutchinson Cancer Center. Seattle, WA, USA/Department of Epidemiology. University of Washington. Seattle, WA, USA.
Center for Public Health Genomics. University of Virginia. Charlottesville, VA, USA.
Universidade Federal de Ciências da Saúde de Porto Alegre. Departamento de Neurologia. Porto Alegre, RS, Brazil.
Department of Cardiology, University of Groningen. University Medical Center Groningen. Groningen, The Netherlands.
The Institute for Translational Genomics and Population Sciences. Department of Pediatrics. The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center. Torrance, CA USA.
Department of Neurology. Miller School of Medicine. University of Miami. FL, USA /The Evelyn F. McKnight Brain Institute. FL, USA.
Department of Neurology. Miller School of Medicine. University of Miami. FL, USA /The Evelyn F. McKnight Brain Institute. FL, USA.
Instituto Nacional de Salud. Lima, Perú.
Instituto de Ciências da Saúde. Universidade Federal do Pará. Belém, PA, Brazil.
Departamento de Farmacologia. Universidade Federal do Rio Grande do Sul. Porto Alegre, RS, Brazil/Serviço de Neurologia. Hospital de Clínicas de Porto Alegre. Porto Alegre, RS, Brazil.
Human Genome and Stem Cell Research Center. University of São Paulo. São Paulo, SP, Brazil.
Channing Division of Network Medicine. Department of Medicine. Brigham and Women’s Hospital. Boston, MA, USA.
Division of Sleep and Circadian Disorders. Brigham and Women’s Hospital. Harvard Medical School. Boston, MA USA.
Channing Division of Network Medicine. Department of Medicine. Brigham and Women’s Hospital. Boston, MA, USA.
Ribeirão Preto Medical School. Universidade de São Paulo. Ribeirão Preto, SP, Brazil.
Channing Division of Network Medicine. Department of Medicine. Brigham and Women’s Hospital. Boston, MA, USA.
Latin American Research Consortium on the Genetics of Parkinson's Disease (LARGE-PD), NINDS Stroke Genetics Network (SiGN) Consortium, TOPMed Population Genetics Working Group
Lerner Research Institute. Genomic Medicine. Cleveland Clinic. Cleveland, OH, USA.
Institute for Human Genetics. University of California. San Francisco, CA, USA/ Bakar Computational Health Sciences Institute. University of California. San Francisco, CA, USA/Quantitative Biosciences Institute. University of California. San Francisco, CA, USA/ Department of Bioengineering and Therapeutic Sciences. University of California San Franciso, CA, USA.
Department of Genetics, Ecology, and Evolution. Instituto de Ciências Biológicas. Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil/ Facultad de Salud Pública y Administración. Universidad Peruana Cayetano Heredia. Lima, Peru.
Institute for Genome Sciences. University of Maryland School of Medicine. Baltimore, MD, USA/ Department of Medicine. University of Maryland School of Medicine. Baltimore, MD, USA./Program in Health Equity and Population Health. University of Maryland School of Medicine. Baltimore, MD, USA/Program in Personalized Genomic Medicine. University of Maryland. School of Medicine. Baltimore, MD, USA.
Abstract
Latin America is underrepresented in genetic studies, which can exacerbate disparities in personalized genomic medicine. However, genetic data of thousands of Latin Americans are already publicly available, but require a bureaucratic maze to navigate all the data access and consenting issues. We present the Genetics of Latin American Diversity (GLAD) Project, a platform that compiles genome-wide information of 54,077 Latin Americans from 39 studies representing 45 geographical regions. Through GLAD, we identified heterogeneous ancestry composition and recent gene-flow across the Americas. Also, we developed a simulated-annealing-based algorithm to match the genetic background of external samples to our database and share summary statistics without transferring individual-level data. Finally, we demonstrate the potential of GLAD as a critical resource for evaluating statistical genetic softwares in the presence of admixture. By making this resource available, we promote genomic research in Latin Americans and contribute to the promises of personalized medicine to more people.
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