Author | Meira, Rafaella de Miranda Villarim | |
Author | Gomes, Sara Lins da Silva | |
Author | Schaeffer, Edgar | |
Author | Silva, Thayssa Da | |
Author | Brito, Andréia Carolinne de Souza | |
Author | Siqueira, Larissa Moreira | |
Author | Inácio, Job Domingos | |
Author | Amaral, Elmo Eduardo Almeida | |
Author | Cruz, Alda Maria da | |
Author | Paiva, Milla Bezerra | |
Author | Neves, Renata Heisler | |
Author | Rodrigues, Luciana Silva | |
Author | Dutra, Patricia Maria Lourenço | |
Author | Costa, Paulo Roberto Ribeiro | |
Author | Silva, Alcides José Monteiro da | |
Author | Silva, Silvia Amaral Gonçalves da | |
Access date | 2023-04-03T14:41:42Z | |
Available date | 2023-04-03T14:41:42Z | |
Document date | 2023 | |
Citation | MEIRA, Rafaella de Miranda Villarim et al. Low doses of 3-phenyl-lawsone or meglumine antimoniate delivery by tattooing route are successful in reducing parasite load in cutaneous lesions of Leishmania (Viannia) braziliensisinfected hamsters. Frontiers in Cellular and Infection Microbiology, v. 13, 1025359. p. 1 - 14, Jan. 2023. | en_US |
ISSN | 2235-2988 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/57658 | |
Language | eng | en_US |
Publisher | Frontiers Media | en_US |
Rights | open access | |
Subject in Portuguese | Leishmania (Viannia) braziliensis | en_US |
Subject in Portuguese | 3-fenil-lawsona | en_US |
Subject in Portuguese | Quimioterapia | en_US |
Subject in Portuguese | Tatuagem | en_US |
Subject in Portuguese | Subcutâneo | en_US |
Subject in Portuguese | Modelo de hamster | en_US |
Title | Low doses of 3-phenyl-lawsone or meglumine antimoniate delivery by tattooing route are successful in reducing parasite load in cutaneous lesions of Leishmania (Viannia) braziliensisinfected hamsters | en_US |
Type | Article | |
DOI | 10.3389/fcimb.2023.1025359 | |
Abstract | Current therapeutic ways adopted for the treatment of leishmaniasis are toxic and
expensive including parasite resistance is a growing problem. Given this scenario, it
is urgent to explore treatment alternatives for leishmaniasis. The aim of this study
was to evaluate the effect of 3-phenyl-lawsone (3-PL) naphthoquinone on
Leishmania (Viannia) braziliensis infection, both in vitro and in vivo, using two
local routes of administration: subcutaneous (higher dose) and tattoo (lower dose).
In vitro 3-PL showed low toxicity for macrophages (CC50 >3200 μM/48h) and
activity against intracellular amastigotes (IC50 = 193 ± 19 μM/48h) and
promastigotes (IC50 = 116 ± 26 μM/72h), in which induced increased ROS
generation. Additionally, 3-PL up-regulated the production of cytokines such as
tumor necrosis factor alpha (TNF-a), monocyte chemotactic protein 1 (MCP-1),
interleukin-6 (IL-6) and IL-10 in infected macrophages. However, the antiamastigote
action was independent of nitric oxide production. Treatment of
hamsters infected with L. (V.) braziliensis from one week after infection with
3-PL by subcutaneous (25 μg/Kg) or tattooing (2.5 μg/Kg) route, during 3 weeks (3 times/week) or 2 weeks (2 times/week) significantly decreased the parasite load
(p<0.001) in the lesion. The reduction of parasite load by 3-PL treatment was
comparable to reference drug meglumine antimoniate administered by the same
routes (subcutaneous 1mg/Kg and tattoo 0.1mg/Kg). In addition, treatment started
from five weeks after infection with 3-PL per tattoo also decreased the parasite
load. These results show the anti-leishmanial effect of 3-PL against L. (V.)
braziliensis and its efficacy by subcutaneous (higher dose) and tattoo (lower
dose) routes. In addition, this study shows that drug delivery by tattooing the
lesion allows the use of lower doses than the conventional subcutaneous route,
which may support the development of a new therapeutic strategy that can be
adopted for leishmaniasis. | en_US |
Affilliation | Universidade do Estado do Rio de Janeiro. Laboratório de Imunofarmacologia Parasitária. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Universidade Federal do Rio de Janeiro. Laboratório de Catálise Orgânica. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Universidade Federal do Rio de Janeiro. Laboratório de Catálise Orgânica. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Universidade do Estado do Rio de Janeiro. Laboratório de Imunofarmacologia Parasitária. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Universidade do Estado do Rio de Janeiro. Laboratório de Imunofarmacologia Parasitária. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Universidade do Estado do Rio de Janeiro. Laboratório de Imunofarmacologia Parasitária. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Universidade do Estado do Rio de Janeiro. Disciplina de Parasitologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | undação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Universidade do Estado do Rio de Janeiro. Laboratório de Helmintologia Romero Lascasas Porto. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Laboratório de Imunopatologia. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Universidade do Estado do Rio de Janeiro. Laboratório de Imunologia do Exercício. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Universidade Federal do Rio de Janeiro, Rio de Janeiro. Laboratório de Quiımica Bioorgânica. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Universidade Federal do Rio de Janeiro. Laboratório de Catálise Orgânica. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Universidade do Estado do Rio de Janeiro. Laboratório de Imunofarmacologia Parasitária. Rio de Janeiro, RJ, Brasil. | en_US |
Subject | Leishmania (Viannia) braziliensis | en_US |
Subject | 3-phenyl-lawsone | en_US |
Subject | Chemotherapy | en_US |
Subject | Tattooing | en_US |
Subject | Subcutaneous | en_US |
Subject | Hamster-model | en_US |