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https://www.arca.fiocruz.br/handle/icict/57643
FIRST REPORT OF A BLANDM-RESISTANT GENE IN A KLEBSIELLA AEROGENES CLINICAL ISOLATE FROM BRAZIL
Affilliation
Universidade Federal de Pernambuco, Departamento de Medicina Tropical, Recife, PE, Brasil.
Fundação, Oswaldo Cruz, Instituto Aggeu Magalhães, Laboratório de Biologia Molecular e Celular, Departamento de Parasitologia, Recife, PE, Brasil.
Abstract
Carbapenemase-resistant enterobacteria that produce the blaNDM gene are found worldwide. However, this is the first
report of blaNDM in Klebsiella aerogenes in Brazil. Methods: The identification of bacterial species was performed using anautomated
system and confirmed by biochemical tests, 16S rRNA gene sequencing, and detection of resistance genes. Results: The clinical isolate
showed minimum inhibitory concentration resistance to meropenem and polymyxin B at 8mg/L and 4mg/L, respectively. Only the
blaNDM gene was detected. Conclusions: The current report of the bla NDM gene in isolated MDR enterobacteria indicates that this gene
can spread silently in a hospital setting.
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