Author | Gonçalves, Pamela Rosa | |
Author | Sousa, Luciana Pereira de | |
Author | Gomes, Flávia Lima Ribeiro | |
Author | Carvalho, Leonardo José Moura | |
Author | Ribeiro, Cláudio Tadeu Daniel | |
Access date | 2023-03-24T12:15:57Z | |
Available date | 2023-03-24T12:15:57Z | |
Document date | 2023 | |
Citation | GONÇALVES, Pamela Rosa et al. Immunomodulation through vaccination as a promising therapeutic strategy to mitigate malaria-related neurocognitive sequelae. Brain, Behavior, and Immunity, v. 109, p. 102-104, 2023. | en_US |
ISSN | 0889-1591 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/57546 | |
Language | eng | en_US |
Publisher | Elsevier | en_US |
Rights | open access | |
Subject in Portuguese | Malária | en_US |
Subject in Portuguese | Disfunção cognitiva | en_US |
Subject in Portuguese | Imunomodulação | en_US |
Subject in Portuguese | Vacina contra tétano-difteria | en_US |
Subject in Portuguese | Melhorador cognitivo | en_US |
Title | Immunomodulation through vaccination as a promising therapeutic strategy to mitigate malaria-related neurocognitive sequelae | en_US |
Type | Article | |
Abstract | Malaria, an ancient infectious parasitic disease, is caused by protozoa of the genus Plasmodium, whose erythrocytic
cycle is accompanied by fever, headache, sweating and chills and a systemic inflammation that can
progress to severe forms of disease, including cerebral malaria. Approximately 25% of survivors of this syndrome
develop sequelae that may include neurological, neurocognitive, behavioral alterations and poor school performance.
Furthermore, some outcomes have also been recorded following episodes of non-severe malaria,
which correspond to the most common clinical form of the disease worldwide. There is a body of evidence that
neuroinflammation, due to systemic inflammation, plays an important role in the neuropathogenesis of malaria
culminating in these cognitive dysfunctions. Preclinical studies suggest that vaccination with type 2 immune
response elicitors, such as the tetanus-diphtheria (Td) vaccine, may exert a beneficial immunomodulatory effect
by alleviating neuroinflammation. In this viewpoint article, vaccination is proposed as a therapy approach to
revert or mitigate neurocognitive deficits associated with malaria. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Colégio Pedro II. Campus Duque de Caxias. Laboratório de Biologia. Duque de Caxias, Rio de Janeiro, Brasil. | en_US |
Affilliation | Colégio Pedro II. Campus Duque de Caxias. Laboratório de Biologia. Duque de Caxias, Rio de Janeiro, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Colégio Pedro II. Campus Duque de Caxias. Laboratório de Biologia. Duque de Caxias, Rio de Janeiro, Brasil. | en_US |
Subject | Malaria | en_US |
Subject | Cognitive dysfunction | en_US |
Subject | Immunomodulation | en_US |
Subject | Tetanus-diphtheria vaccine | en_US |
Subject | Cognitive enhancer | en_US |
e-ISSN | 10.1016/j.bbi.2023.01.007 | |