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https://www.arca.fiocruz.br/handle/icict/57394
REGULATION OF INNATE IMMUNE SIGNALING BY IRAK PROTEINS
Affilliation
Division of Infectious Diseases and Immunology. Department of Medicine. University of Massachusetts Chan Medical School. Worcester, MA, USA.
Division of Infectious Diseases and Immunology. Department of Medicine. University of Massachusetts Chan Medical School. Worcester, MA, USA / Universidade Federal de Minas Gerais. Centro de Tecnologia de Vacinas. Belo Horizonte, MG, Brazil / Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil / Fundação Oswaldo Cruz. Fiocruz São Paulo. Plataforma de Medicina Translacional. Ribeirão Preto, SP, Brazil.
Division of Infectious Diseases and Immunology. Department of Medicine. University of Massachusetts Chan Medical School. Worcester, MA, USA / Universidade Federal de Minas Gerais. Centro de Tecnologia de Vacinas. Belo Horizonte, MG, Brazil / Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil / Fundação Oswaldo Cruz. Fiocruz São Paulo. Plataforma de Medicina Translacional. Ribeirão Preto, SP, Brazil.
Abstract
The Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1R) families are of paramount importance in coordinating the early immune response to pathogens. Signaling via most TLRs and IL-1Rs is mediated by the protein myeloid differentiation primary-response protein 88 (MyD88). This signaling adaptor forms the scaffold of the myddosome, a molecular platform that employs IL-1R-associated kinase (IRAK) proteins as main players for transducing signals. These kinases are essential in controlling gene transcription by regulating myddosome assembly, stability, activity and disassembly. Additionally, IRAKs play key roles in other biologically relevant responses such as inflammasome formation and immunometabolism. Here, we summarize some of the key aspects of IRAK biology in innate immunity.
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