Author | Reis, Mitermayer Galvão dos | |
Author | Andrade, Zilton de Araújo | |
Access date | 2012-10-26T17:48:21Z | |
Available date | 2012-10-26T17:48:21Z | |
Document date | 1987 | |
Citation | REIS, M.G. dos; ANDRADE, Z.A. Efeito da quimioterapia sobre os ovos do Schistosoma mansoni. Memórias do Instituto Oswaldo Cruz, v. 82, n. 2, p. 161-5, apr.-jun. 1987. | pt_BR |
ISSN | 0074-0276 | |
URI | https://www.arca.fiocruz.br/handle/icict/5736 | |
Language | eng | pt_BR |
Rights | open access | |
Title | Efeito da quimioterapia sobre os ovos do Schistosoma mansoni. | pt_BR |
Type | Article | pt_BR |
Abstract | Praziquantel administered to mice with Schistosoma mansoni infection (50 cercarias/8 weeks) was observed to cause death of adult worms and disintegration of the eggs trapped within granulomas, sometimes with calcification, after the 4th day of treatment. Combined administration of oxamniquine/hycanthone to animals similarly infected, although quite effective in killing adult worms, did not interfere with the eggs in the tissue. The miracidium eclosion test was positive up to the 15th day after the curative treatment of these animals. Since praziquantel treatment causes a rapid destruction of eggs, possible serological and pathogenic effects are expected that may enable a faster reabsorption of granulomas by the host tissues than that produced by other equally effective drugs. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Subject | Chemotherapy | pt_BR |
Subject | Miracidium | pt_BR |
Subject | Schistosoma Mansoni | pt_BR |
Subject | Praziquantel | pt_BR |
Subject | Oxamniquine/hycanthone | pt_BR |
DeCS | Óvulo/efeitos de drogas | pt_BR |
DeCS | Praziquantel/farmacologia | pt_BR |
DeCS | Schistosoma mansoni/efeitos de drogas | pt_BR |
DeCS | Esquistossomose mansoni/quimioterapia | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Quimioterapia Combinada | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Hicantone/farmacologia | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Camundongos | pt_BR |
DeCS | Oxamniquine/farmacologia | pt_BR |